{"id":1643,"date":"2020-10-28T13:23:10","date_gmt":"2020-10-28T17:23:10","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/?post_type=dt_team&#038;p=1643"},"modified":"2023-09-25T13:49:44","modified_gmt":"2023-09-25T17:49:44","slug":"dr-demetrio-sierra-mercado","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/dt_team\/dr-demetrio-sierra-mercado\/","title":{"rendered":"Sierra-Mercado, Demetrio, PhD"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-731969da73d514558\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-731969da73d514558 uvc-9259 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-731969da73d514558 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Sierra-Mercado, Demetrio, PhD<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-731969da73d514558 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Associate Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-ed383e1ad75509d8f7c6094e1fdf3bce.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-ed383e1ad75509d8f7c6094e1fdf3bce.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-ed383e1ad75509d8f7c6094e1fdf3bce .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-ed383e1ad75509d8f7c6094e1fdf3bce .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-ed383e1ad75509d8f7c6094e1fdf3bce alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-content\/uploads\/sites\/23\/2020\/10\/drsierra.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-content\/uploads\/sites\/23\/2020\/10\/drsierra.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/dt_team\/dr-demetrio-sierra-mercado\/drsierra\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Demetrio Sierra\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8281\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8281 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:demetrio.sierra@upr.edu\">demetrio.sierra@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-7584\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-7584 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">Dr. Guillermo Arbona Irizarry Bldg.<\/span><br \/>\n<span style=\"color: #ffffff;\">5th Floor, Office A501A, Lab A544\/A538<\/span><\/p>\n<p><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2525\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2525 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787-758-2525 x1572 (office), x1521 (lab)<\/span><\/p>\n<p><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S.: Biology, Minor in Chemistry (University of Texas at San Antonio)<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph.D.: Biomedical Sciences &#8212; Neuroscience (Ponce School of Medicine, Ponce, Puerto Rico)<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoctoral training: Behavioral neuroscience, neurophysiology, and brain injury (Massachusetts General Hospital\/Harvard Medical School, Boston, MA)<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-59869da73d51525f\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-59869da73d51525f uvc-1365  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-59869da73d51525f h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Research Interest:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-59869da73d51525f .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Effects serious cranioencephalic trauma on memory formation and expression<\/div><\/div>[vc_empty_space][vc_row_inner][vc_column_inner]<div id=\"ultimate-heading-159869da73d5152cc\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-159869da73d5152cc uvc-4838  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-159869da73d5152cc h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Present Funding:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-159869da73d5152cc .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">NIH R21, NIH COBRE, NIH RCMI<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-707969da73d515329\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-707969da73d515329 uvc-5041  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-707969da73d515329 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Selected Publications:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-707969da73d515329 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Kostick-Quenet K, Kalwani L, Koenig B, Torgerson L, Sanchez C, Munoz K, Hsu RL, <strong>Sierra-Mercado D<\/strong>, Robinson JO, Outram S, Pereira S, McGuire A, Zuk P, Lazaro-Munoz G (2022) Researchers&#8217; Ethical Concerns About Using Adaptive Deep Brain Stimulation for Enhancement. Front Hum Neurosci. 2022 Apr 14;16:813922. doi: 10.3389\/fnhum.2022.813922. PMID: 35496073; PMCID: PMC9050172.<\/li>\n<li>Zuk P, Sanchez CE, Kostick-Quenet K, Mu\u00f1oz KA, Kalwani L, Lavingia R, Torgerson L, <strong>Sierra-Mercado D<\/strong>, Robinson JO, Pereira S, Outram S, Koenig BA, McGuire AL, L\u00e1zaro-Mu\u00f1oz G (2022) Researcher Views on Changes in Personality, Mood, and Behavior in Next-Generation Deep Brain Stimulation. AJOB Neurosci. 2022 Apr 18:1-13. doi: 10.1080\/21507740.2022.2048724. Epub ahead of print. PMID: 35435795; PMCID: PMC9639000.<\/li>\n<li>Outram S, Mu\u00f1oz KA, Kostick-Quenet K, Sanchez CE, Kalwani L, Lavingia R, Torgerson L, <strong>Sierra-Mercado D<\/strong>, Robinson JO, Pereira S, Koenig BA, Starr PA, Gunduz A, Foote KD, Okun MS, Goodman WK, McGuire AL, Zuk P, L\u00e1zaro-Mu\u00f1oz G. Patient, Caregiver, and Decliner Perspectives on Whether to Enroll in Adaptive Deep Brain Stimulation Research. Front Neurosci. 2021 Oct 7;15:734182. doi: 10.3389\/fnins.2021.734182. PMID: 34690676; PMCID: PMC8529029.<\/li>\n<li>Mu\u00f1oz KA, Kostick K, Sanchez C, Kalwani L, Torgerson L, Hsu R, <strong>Sierra-Mercado D<\/strong>, Robinson JO, Outram S, Koenig BA, Pereira S, McGuire A, Zuk P, L\u00e1zaro-Mu\u00f1oz G (2020) Researcher perspectives on ethical considerations in adaptive deep brain stimulation trials. Front Hum Neurosci Nov 12; 14:578695. doi: 10.3389\/fnhum.2020.578695. eCollection 2020.PMID: 33281581<\/li>\n<li>Zuk P, Sanchez CE, Kostick K,Torgerson L, Mu\u00f1oz KA, Hsu R, Kalwani L, <strong>Sierra-Mercado D<\/strong>, Robinson JO, Outram S, Koenig BA, Pereira S, McGuire AL, L\u00e1zaro-Mu\u00f1oz G (2020) Researcher perspectives on data sharing in deep brain stimulation. Front Hum Neurosci Dec 17; 14:578687. doi: 10.3389\/fnhum.2020.578687. eCollection 2020.PMID: 33424563<\/li>\n<li>L\u00e1zaro-Mu\u00f1oz G, Zuk P, Pereira S, Kostick K, Torgerson L, <strong>Sierra-Mercado D<\/strong>, Majumder M, Blumenthal-Barby J, Storch EA, Goodman WK, McGuire AL. (2019) Neuroethics at 15: Keep the Kant but Add More Bacon. AJOB Neurosci. 2019 Jul-Sep;10(3):97-100. doi: 10.1080\/21507740.2019.1632960. No abstract available. PMID: 31329079<\/li>\n<li><strong>Sierra-Mercado D<\/strong>, Zuk P, Beauchamp MS, Sheth SA, Yoshor D, Goodman WK, McGuire AL, L\u00e1zaro-Mu\u00f1oz G. (2019) Device Removal Following Brain Implant Research. Neuron. 2019 Sep 4;103(5):759-761. doi: 10.1016\/j.neuron.2019.08.024. PMID: 31487526<\/li>\n<li>Kostick KM, <strong>Sierra-Mercado D<\/strong>, L\u00e1zaro-Mu\u00f1oz G. (2019) Ethical and Social Considerations for Increasing Use of DTC Neurotechnologies. AJOB Neurosci. 2019 Oct-Dec;10(4):183-185. doi: 10.1080\/21507740.2019.1665131. No abstract available. PMID: 31642754<\/li>\n<li>Zuk P, Torgerson L, <strong>Sierra-Mercado D<\/strong>, L\u00e1zaro-Mu\u00f1oz G. (2018) Neuroethics of Neuromodulation: An Update. Curr Opin Biomed Eng. 2018 Dec;8:45-50. doi: 10.1016\/j.cobme.2018.10.003. Epub 2018 Oct 26. PMID: 30687802<\/li>\n<li><strong>\u00a0<\/strong><strong>Sierra-Mercado D<\/strong>, L\u00e1zaro-Mu\u00f1oz G. (2018) Enhance Diversity Among Researchers to Promote Participant Trust in Precision Medicine Research. Am J Bioeth. 2018 Apr;18(4):44-46. PMID: 29621450<\/li>\n<li>Gatica RI, P\u00e9rez-Valenzuela E, <strong>Sierra-Mercado D<\/strong>, Fuentealba JA (2017) The expression of amphetamine sensitization is disociable from anxiety and aversive memory: Effect of an acute injection of amphetamine. Neurosci Lett 638:21-26<\/li>\n<li><strong>\u00a0<\/strong>Ishizawa Y, Ahmed OJ, Patel SR, Gale JT, <strong>Sierra-Mercado D<\/strong>, Brown EN, Eskandar EN (2016) Dynamics of propofol-induced loss of consciousness across primate neocortex, J Neurosci 36(29):7718-7726<\/li>\n<li><strong>\u00a0<\/strong><strong>Sierra-Mercado D<\/strong>, McAllister LM, Lee CC, Milad MR, Eskandar EN, Whalen MJ (2015) Controlled cortical impact before or after fear conditioning does not affect fear extinction in mice. Brain Res 1606:133-141.<\/li>\n<li><strong>\u00a0<\/strong><strong>Sierra-Mercado D<\/strong>, Deckersbach T, Arulpragasam AR, Chou T, Rodman AM, Duffy A, McDonald EJ, Eckhardt CA, Corse AK, Kaur N, Eskandar EN, Dougherty DD (2014) Decision making in avoidance-reward conflict: a paradigm for non-human primates and humans Brain Structure &amp; Function. Epub 27-Jun.<\/li>\n<li>Sotres-Bayon F, <strong>Sierra-Mercado D<\/strong>, Pardilla-Delgado E, Quirk GJ (2012) Gating of fear in prelimbic cortex by hippocampal and amygdala inputs. 76, 804-812.<\/li>\n<li><strong>Sierra-Mercado D<\/strong>, Padilla-Coreano N, Quirk GJ (2011) Dissociable roles of prelimbic and infralimbic cortices, ventral hippocampus, and basolateral amygdala in the expression and extinction of conditioned fear. 36(2): 529-38.<\/li>\n<li>Sotres-Bayon F, Corcoran KA, Peters J, <strong>Sierra-Mercado D<\/strong> (2008) Neural Correlates of Individual Variability in Fear Extinction. Journal of Neuroscience. 28(47):12147-12149.<\/li>\n<li><strong>Sierra-Mercado D<\/strong>, Dieguez D Jr, and Barea-Rodriguez EJ (2008) Brief Novelty Exposure Facilitates Dentate Gyrus LTP in Aged Rats. Hippocampus. 18(8):835-43.<\/li>\n<li>Devan BD, <strong>Sierra-Mercado D<\/strong>, Jimenez M, Bowker JL, Duffy KB, Spangler EL, Ingram DK (2004) Phosphodiesterase inhibition by sildenafil citrate attenuates the learning impairment induced by blockade of cholinergic muscarinic receptors in rats. Pharmacology, Biochemistry and Behavior. 79:691-9.<\/li>\n<li>Devan BD, Pistell PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, <strong>Sierra-Mercado D<\/strong>, Spangler EL, Ingram DK (2007) Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. European Journal of Pharmacology. 563(1-3):134-40.7.<\/li>\n<li><strong>Sierra-Mercado D<\/strong>, Corcoran KA, Lebron-Milad K, Quirk GJ. (2006) Inactivation of the ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction. European Journal of Neuroscience. 24:1751-8.8.<\/li>\n<li>Devan BD, Bowker JL, Duffy K, Bharati IS, Jimenez M, <strong>Sierra-Mercado D<\/strong>, Nelson CM, Spangler EL, Ingram DK (2006) Phosphodiesterase inhibition by sildenafil citrate attenuates a maze learning impairment in rats induced by nitric oxide synthase inhibition. Psychopharmacology. 183:439-45.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_row_inner][vc_column_inner][vc_empty_space][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1952,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[42],"class_list":["post-1643","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-associate-professor","dt_team_category-42","description-off"],"aioseo_notices":[],"jetpack_sharing_enabled":true,"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/dt_team\/1643","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/comments?post=1643"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/media\/1952"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/media?parent=1643"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/anatomyneurobiology\/wp-json\/wp\/v2\/dt_team_category?post=1643"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}