{"id":801,"date":"2016-03-09T14:11:58","date_gmt":"2016-03-09T18:11:58","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/biochemistry\/?post_type=dt_team&#038;p=801"},"modified":"2023-03-10T14:02:49","modified_gmt":"2023-03-10T18:02:49","slug":"dr-jose-r-rodriguez-medina","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-jose-r-rodriguez-medina\/","title":{"rendered":"Dr. Jos\u00e9 R. Rodr\u00edguez Medina"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-589469d25102113c4\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-589469d25102113c4 uvc-8480 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-589469d25102113c4 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Jos\u00e9 R. Rodr\u00edguez-Medina<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-589469d25102113c4 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-e031eb1ff82c73b67f85abfe5a2e1ac9.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-e031eb1ff82c73b67f85abfe5a2e1ac9.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-e031eb1ff82c73b67f85abfe5a2e1ac9 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-e031eb1ff82c73b67f85abfe5a2e1ac9 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-e031eb1ff82c73b67f85abfe5a2e1ac9 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/Jose-R-RODRIGUEZ.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/Jose-R-RODRIGUEZ.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-jose-r-rodriguez-medina\/jose-r-rodriguez\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Jos\u00e9 R. Rodr\u00edguez Medina\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-5620\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-5620 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:jose.rodriguez123@upr.edu\">jose.rodriguez123@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-1808\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-1808 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Department of Biochemistry<\/span><br \/>\n<span style=\"color: #ffffff;\">School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico<\/span><br \/>\n<span style=\"color: #ffffff;\">PO Box 365067<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, P.R. 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6377\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6377 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">(787) 758-2525, extensions 2299 or 1601<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">Post-doctoral Biochemistry and Molecular Biology, 1989<\/span><br \/>\n<span style=\"color: #ffffff;\">National Institutes of Health<\/span><\/li>\n<li><span style=\"color: #ffffff;\">PhD Biology, 1986<\/span><br \/>\n<span style=\"color: #ffffff;\">Brandeis University<\/span><\/li>\n<li><span style=\"color: #ffffff;\">MS\u00a0 Biology, 1980<\/span><br \/>\n<span style=\"color: #ffffff;\">UPR &#8211; Rio Piedras Campus<\/span><\/li>\n<li><span style=\"color: #ffffff;\">B.Sc.\u00a0 Biology, 1978<\/span><br \/>\n<span style=\"color: #ffffff;\">UPR &#8211; Rio Piedras<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]There is a worldwide surge in fungal infections due to increased longevity in the human population, prevalence of individuals with compromised immune systems, and widespread use of antibiotics fueling a surge in drug-resistant strains. To design novel strategies to overcome resistance to antifungals, we need to address the gap in knowledge of the molecular mechanisms that enable pathogenic fungi to overcome the metabolic stress of antifungal treatments. Our long-term research goal is to identify key metabolic processes that enable infectious fungi to survive under stress conditions as potential targets for therapeutic antifungals. Our approach is to identify key signaling molecules controlling metabolic mechanisms in the budding yeast Saccharomyces cerevisae that are evolutionarily conserved in pathogenic fungi, and promote fungal survival under conditions of physiological stress. Normal or pathogenic stress conditions that can compromise cellular integrity such as: cell wall damage by chemical agents (antifungal agents, antibiotics, etc.), heat shock, oxidizing chemicals such as hydrogen peroxide, are detected by stress mechanosensor proteins in the plasma membrane of S. cerevisae. These mechanosensor proteins physically interact with specific signaling proteins that transduce stress signals from the fungal cell wall to the cytosol where the signaling machinery initiates the survival response. Our current research is therefore focused on the identification and functional characterization of key signaling proteins that interact with these mechanosensor proteins to confer resistance to antifungal drugs, oxidizing chemicals, and heat stress.[\/vc_column_text][vc_empty_space]<div id=\"ultimate-heading-651869d2510214c3a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-651869d2510214c3a uvc-7628  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-651869d2510214c3a h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Selected Publications:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-651869d2510214c3a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Nelson Mart\u00ednez-Mat\u00edas, Nataliya Chorna, Sahily Gonz\u00e1lez\u2013Crespo, Lilliam Villanueva, Ingrid Montes\u2013Rodr\u00edguez, et al. \u201cTowards the discovery of\u00a0biological functions associated with the mechanosensor\u00a0Mtl1p of\u00a0<em>Saccharomyces cerevisiae<\/em>\u00a0via\u00a0integrative multi-OMICs analysis.\u201d Scientific Reports, Article DOI: 10.1038\/s41598-021-86671-8<em>.<\/em>\u00a0Sci Rep. 2021 Apr 1;11(1):7411. doi: 10.1038\/s41598-021-86671-8. PMID: 33795741.<\/li>\n<li>Vladimir V\u00e9lez-Segarra,\u00a0Sahily Gonz\u00e1lez-Crespo,\u00a0Ednalise Santiago-Cartagena,\u00a0Luis E. V\u00e1zquez-Qui\u00f1ones,\u00a0Nelson Mart\u00ednez-Mat\u00edas,\u00a0et al. \u201cProtein Interactions of the Mechanosensory Proteins Wsc2 and Wsc3 for Stress Resistance in\u00a0<em>Saccharomyces cerevisiae.\u201d\u00a0<\/em>G3 (Bethesda). 2020 Sep 2;10(9):3121-3135. doi: 10.1534\/g3.120.401468. PMID: 32641451.<\/li>\n<li>Ednalise Santiago-Cartagena, Sahily Gonz\u00e1lez, Vladimir Velez, Nelson Mart\u00ednez, Jamie Snider, et al. \u201cIdentification and functional testing of novel interacting protein partners for the stress sensors Wsc1p and Mid2p of\u00a0<em>Saccharomyces cerevisiae<\/em>.\u201d G3 (Bethesda) 2019 Apr 9;9(4):1085-1102. doi: 10.1534\/g3.118.200985. PMID: 30733383<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]There is a worldwide surge in fungal infections due to increased longevity in the human population, prevalence of individuals with compromised immune systems, and widespread use of antibiotics fueling a surge in drug-resistant strains. To design novel strategies to overcome resistance to antifungals, we need to address the gap in knowledge&hellip;<\/p>\n","protected":false},"featured_media":1094,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-801","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team\/801","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/comments?post=801"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media\/1094"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media?parent=801"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team_category?post=801"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}