{"id":802,"date":"2016-03-09T14:13:37","date_gmt":"2016-03-09T18:13:37","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/biochemistry\/?post_type=dt_team&#038;p=802"},"modified":"2023-03-17T10:11:14","modified_gmt":"2023-03-17T14:11:14","slug":"dr-jose-f-rodriguez-orengo","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-jose-f-rodriguez-orengo\/","title":{"rendered":"Dr. Jos\u00e9 F. Rodr\u00edguez Orengo"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-407569d2a165684f6\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-407569d2a165684f6 uvc-4801 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-407569d2a165684f6 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Jos\u00e9 F. Rodr\u00edguez Orengo<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-407569d2a165684f6 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-036cd82333ff1c0640bb1d77a68d641e.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-036cd82333ff1c0640bb1d77a68d641e.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-036cd82333ff1c0640bb1d77a68d641e .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-036cd82333ff1c0640bb1d77a68d641e .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-036cd82333ff1c0640bb1d77a68d641e alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/rodriguez-orengo.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/rodriguez-orengo.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-jose-f-rodriguez-orengo\/rodriguez-orengo\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Jos\u00e9 F. Rodr\u00edguez Orengo\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8142\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8142 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/md.rcm.upr.edu\/biochemistry\/jose-f-rodriguez-orengo-ph-d\/jose.rodriguez139@upr.edu\">jose.rodriguez139@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-4238\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-4238 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2358\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2358 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Phone: (787) 758-2525 ext. 1349<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">NSF Post Doctoral Fellowship, 1991<\/span><br \/>\n<span style=\"color: #ffffff;\">Cornell University<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Doctor of Philosophy (Ph.D.), 1989<\/span><br \/>\n<span style=\"color: #ffffff;\">Texas A&amp;M University<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Bachillerato en Ciencias (Qu\u00edmica), 1985<\/span><br \/>\n<span style=\"color: #ffffff;\">UPR R\u00edo Piedras<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Master in Public Health, 2022<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico, RCM<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Dr. Jos\u00e9 F. Rodr\u00edguez-Orengo is Professor at the Department of Biochemistry, School of Medicine at the University of Puerto Rico and has more than 25 years of experience in higher education and scientific research with more than 80 peer-reviewed articles (basic, clinical, public health). He is the leader of the student activities of the Puerto Rico IDeA Network for Biomedical Research where more than 500 students have participated actively in the program. He is also Senior Consultant for the Puerto Rico Science, Technology, and Research Trust and Executive Director of the PR Public Health Trust. He was Executive Director at the Puerto Rico Institute of Forensic Sciences where he completed a radical transformation using lean-six-sigma to increase productivity and improve the quality of the processes. He was Acting Chancellor at the UPR-Medical Sciences Campus that transformed the IT system to benefit the educational and research endeavors. With a research group of UPR-Medical Sciences Campus\u2019 Professors, he is one of the founder members of MBQ Pharma, the first Pharmaceutical Company developing anticancer products patented by the UPR. He was awarded in 2019 the Osvaldo Ramirez Award, the highest distinction for a chemist in Puerto Rico. He has the vision of integration and collaboration among different entities towards a common goal of promoting Puerto Rico as a premier site for research.[\/vc_column_text]<div id=\"ultimate-heading-483669d2a1656af07\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-483669d2a1656af07 uvc-2382  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-483669d2a1656af07 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Research Interests<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-483669d2a1656af07 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Our research interest revolves around Molecular Toxicology. We are involved in two main areas of research:<\/p>\n<p>A. Gene Discovery: Most of the research in this area involves theuse of state of the art molecular biology techniques such as the commonly known Differential Display Reverse Transcription -PCR (DDRT-PCR technique which identifies differentially expressed mRNA species; 5\u2032 RACE PCR (for the isolation of full length cDNAs) and the use of Panhandle PCR (to retrieve genomic segments flanking a known DNA sequence (obtained from the full length cDNA).<\/p>\n<ol>\n<li>These techniques are being employed to isolate genes that are regulated by immunosuppressive drugs such as Dexamethasone and an antiglucocorticoid compound, Pregnenolone-16-a-carbonitrile. It is joint collaborative effort with Dr. Philip Guzelian (Univ. of Colorado). The ultimate goal of this research is to identify and study the regulation of new genes that may be associated with metabolism of xenobiotic compounds including environmental pollutants.<\/li>\n<li>This same approach is being used to isolate and identify genes that are associated with cancer (oncogenes). Most of the works performed on colorectal cancer oncogenes have been done on Caucasian and Japanese population, with little or no representation of the Hispanic population. Our research proposes to identify specific genes and isolate cDNA probes for colon cancer genes that may be expressed in the cancer patients from the Hispanic population and can eventually be used for diagnostics and treatment of cancer.<\/li>\n<\/ol>\n<p>B. Environmental Toxicology: We are interested in identifying and studying genes that are affected by environmental pollutants (particularly from air). In collaboration with Dr. Carmen L. Cadilla<\/p>\n<p>(UPR-MSC) and Dr. Ben Van Houten (Galveston, Tx) we are developing technologies to evaluate DNA integrity (Genotoxicity) using molecular toxicology techniques such as quantitative XL-PCR. We are studying DNA damage caused by pollutants in mitochondrial and nuclear DNA. The ultimate goal of this research is to develop a sensitive bioassay which could be used to evaluate environmental exposure in different populations.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-736569d2a1656af5d\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-736569d2a1656af5d uvc-5865  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-736569d2a1656af5d h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Selected Publications:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-736569d2a1656af5d .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Associations Between Perceived Stress and Dietary Intake in Adults in Puerto Rico. L\u00f3pez-Cepero A, O&#8217;Neill J, Tamez M, Falc\u00f3n LM, Tucker KL, Rodr\u00edguez-Orengo JF, Mattei J.J Acad Nutr Diet. 2021 Apr;121(4):762-769. doi: 10.1016\/j.jand.2020.09.035. Epub 2020 Oct 24.PMID: 33109502<\/li>\n<li>Syndromic Surveillance in Puerto Rico During the COVID-19 Response: An Alternative Approach to Scarce Molecular Testing. Marzan-Rodriguez M, Morales LM, Martinez IS, Serrano RA, Mattei J, Rodriguez-Orengo JF, Thompson K.Am J Public Health. 2020 Sep;110(9):1348-1349. doi: 10.2105\/AJPH.2020.305805<\/li>\n<li>The association between purchasing locally produced food and diet quality among adults in Puerto Rico. Marrero A, Tamez M, Rodr\u00edguez-Orengo JF, Mattei J.Public Health Nutr. 2020 Sep 9:1-10. doi: 10.1017\/S1368980020003134. Online ahead of print.PMID: 32900415<\/li>\n<li>Higher eating frequency, but not skipping breakfast, is associated with higher odds of abdominal obesity in adults living in Puerto Rico. Tamez M, Rodriguez-Orengo JF, Mattei J.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Dr. Jos\u00e9 F. Rodr\u00edguez-Orengo is Professor at the Department of Biochemistry, School of Medicine at the University of Puerto Rico and has more than 25 years of experience in higher education and scientific research with more than 80 peer-reviewed articles (basic, clinical, public health). He is the leader of the student&hellip;<\/p>\n","protected":false},"featured_media":1099,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-802","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team\/802","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/comments?post=802"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media\/1099"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media?parent=802"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team_category?post=802"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}