{"id":803,"date":"2016-03-09T14:14:29","date_gmt":"2016-03-09T18:14:29","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/biochemistry\/?post_type=dt_team&#038;p=803"},"modified":"2023-12-06T07:40:22","modified_gmt":"2023-12-06T11:40:22","slug":"dr-pablo-e-vivas-mejia","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-pablo-e-vivas-mejia\/","title":{"rendered":"Dr. Pablo E. Vivas-Mej\u00eda"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-644369d25102eee0e\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-644369d25102eee0e uvc-8453 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-644369d25102eee0e h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Pablo E. Vivas-Mej\u00eda<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-644369d25102eee0e .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Associate Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-acb1add4f1cb5d2dbd6bf6dab055cafe.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-acb1add4f1cb5d2dbd6bf6dab055cafe.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-acb1add4f1cb5d2dbd6bf6dab055cafe .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-acb1add4f1cb5d2dbd6bf6dab055cafe .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-acb1add4f1cb5d2dbd6bf6dab055cafe alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/PABLO-VIVAS.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-content\/uploads\/sites\/24\/2016\/03\/PABLO-VIVAS.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-pablo-e-vivas-mejia\/pablo-vivas\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Pablo E. Vivas-Mej\u00eda\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-9188\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-9188 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6039\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6039 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Department of Biochemistry &amp; Cancer Center<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus, San Juan, Puerto Rico<\/span><\/p>\n<p><span style=\"color: #ffffff;\">Department of Surgical Oncology<\/span><br \/>\n<span style=\"color: #ffffff;\">MD Anderson Cancer Center<\/span><br \/>\n<span style=\"color: #ffffff;\">Houston, Texas<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3222\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3222 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">Ph.D. Chemistry, 2022<\/span><br \/>\n<span style=\"color: #ffffff;\">UPR &#8211; R\u00edo Piedras<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. Chemistry, 1997<\/span><br \/>\n<span style=\"color: #ffffff;\">|UPR &#8211; R\u00edo Piedras<\/span><\/li>\n<li><span style=\"color: #ffffff;\">\\icenciado en Quimica, 1991<\/span><br \/>\n<span style=\"color: #ffffff;\">Universidad Nacional Bogota-Colombia<\/span><\/li>\n<li><span style=\"color: #ffffff;\">MD Anderson<\/span><br \/>\n<span style=\"color: #ffffff;\">Postdoctoral fellow<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Dr. Pablo E. Vivas-Mejia is an assistant professor in the Department of Biochemistry &amp; Cancer Center at the University of Puerto Rico Medical Sciences Campus. Dr. Vivas-Mejia\u2019s major interest areas are to understand the mechanisms by which cancer cells become resistant to chemotherapy and to design and test small interference RNA (siRNA) and microRNA (miRNA)-based therapies for advanced cancers that are resistant to current standard chemotherapy regimens. Dr. Vivas-Mejia\u2019s possesses a broad background in biochemistry, cellular and molecular biology, and cancer medicine. Dr. Vivas-Mejia expertise includes the use of siRNA and miRNA-nanoliposomal formulations and their delivery to both cultured cells and mouse models.[\/vc_column_text]<div id=\"ultimate-heading-146869d25102f350a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-146869d25102f350a uvc-184  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-146869d25102f350a h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Research Projects<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-146869d25102f350a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Mechanisms of drug resistance in ovarian cancer: c-MYC, ILK and miRNAs<\/p>\n<p>MicroRNA as diagnostic and therapeutic targets in glioblastoma multiforme<\/p>\n<p>Nanoparticles for drug delivery: gold nanoparticles and nanoliposomes for siRNA and miRNA delivery.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-397969d25102f3566\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-397969d25102f3566 uvc-7045  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-397969d25102f3566 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Selected Publications:<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-397969d25102f3566 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><u>Book Chapters<\/u><\/p>\n<p>Illeabett Echevarria and\u00a0<strong>Pablo E. Vivas-Mej\u00eda<\/strong>, Assessment of mRNA Splice Variants by qRT-PCR. Book Chapter: Humana Press series \u201cMethods in Molecular Biology\u201d,\u00a0<strong>2013<\/strong>.\u00a0<em>ISBN 978-1-62703-546-0<\/em><\/p>\n<p>Jeyshka Reyes, Frances Pietri,\u00a0<strong>Pablo E. Vivas-Mejia<\/strong>. Nano Based Drug Delivery. Chapter 12. A general overview of the nano-sized carriers for cancer treatment, Edited by Jitendra Naik,\u00a0<strong>2015<\/strong>. ISBN: 978-953-56942-2-9.<\/p>\n<p><u>Paper Published<\/u><\/p>\n<p>Jeyshka M. Reyes-Gonz\u00e1lez, Guillermo N. Armaiz-Pe\u00f1a, Lingegowda S. Mangala, Fatma Valiyeva, Cristina Ivan, Sunila Pradeep, Ileabett Echevarria-Vargas, Adrian Rivera, Anil K. Sood, and\u00a0<strong>Pablo E. Vivas-Mejia<\/strong>. Targeting c-MYC in platinum-resistant ovarian cancer. Molecular Cancer Therapeutics, October, 2015.<\/p>\n<p>M\u00f3nica Rivera-Diaz,\u00a0 Daniel Soto, Mario Quintero-Aguilo, Humberto Ortiz-Zuazaga, Mar\u00eda J. Marcos-Martinez, and Pablo E. Vivas-Mej\u00eda. MicroRNA-27a Distinguishes Glioblastoma Multiforme from Diffuse and Anaplastic Astrocytomas and Has Prognostic Value. American Journal of Cancer Research, November 2014.<\/p>\n<p>Ileabett M. Echevarr\u00eda Vargas, Fatma Valiyeva<sup>1<\/sup>\u00a0and\u00a0<strong>Pablo E. Vivas-Mej\u00eda<\/strong>. Upregulation of miR-21 in cisplatin resistant ovarian cancer via JNK-1\/c-Jun pathway. PLosOne. 2014; 9: e97094. doi:10.1371\/journal.pone.0097094.<\/p>\n<p>Diaz, MR,\u00a0<strong>Vivas-Mejia, PE<\/strong>*. Nanoparticles as drug Delivery Systems in Cancer Medicine: Emphasis on RNAi-containing Nanoliposomes. Review article. Pharmaceuticals 2013, 6, 1362-1380.<\/p>\n<p>Armaiz-Pena GN, Allen JK, Cruz A, Stone RL, Nick AM, Lin YG, Han LY, Mangala LS, Villares GJ,\u00a0<strong>Vivas-Mejia P<\/strong>, Rodriguez-Aguayo C, Nagaraja AS, Gharpure KM, Wu Z, English RD, Soman KV, Shazhad MM, Zigler M, Deavers MT, Zien A, Soldatos TG, Jackson DB, Wiktorowicz JE, Torres-Lugo M, Young T, De Geest K, Gallick GE, Bar-Eli M, Lopez-Berestein G, Cole SW, Lopez GE, Lutgendorf SK, Sood AK.\u00a0 Src activation by \u03b2-adrenoreceptors is a key switch for tumour metastasis.\u00a0 Nat Commun. 2013 Jan 29;4:1403. doi: 10.1038\/ncomms2413. PMID:23360994<\/p>\n<p>Myrthala Moreno-Smith, J.B. Halder, Paul Meltzer, Tamas Gonda, Lingegowda Mangala,\u00a0<strong>Pablo Vivas-Mejia<\/strong>, Behrouz Zand, Rosemarie Schmandt, Hua Wang, Robert Langley, Nicholas B. Jennings, Cristina Ivan, Jeremy Coffin, Guillermo N Armaiz-Pena, Justin Bottsford-Miller, Chad Pecot, Sang-Bae Kim, Margaret Halleck, Mary J. C. Hendrix, William Bornmann, Menashe Bar-Eli, Ju-Seog Lee, Zahid Siddik, Gabriel lopez-berestein and Anil Sood. Unexpected roles of ATP11B in platinum resistance.\u00a0<em>JCI.<\/em>\u00a02013. DOI:10.1172\/JCI65425.<\/p>\n<p><strong>Pablo E. Vivas-Mejia<sup>*<\/sup><\/strong>, Cristian Rodriguez-Aguayo, Hee-Dong Han, Mian M.K. Shahzad<sup>,<\/sup>\u00a0Fatma Valiyeva, Mineko Shibayama, Arturo Chavez-Reyes, Anil K. Sood, and Gabriel Lopez-Berestein<strong><sup>*<\/sup><\/strong>. Silencing Survivin Splice Variant 2B Leads to Antitumor Activity in Taxane-Resistant Ovarian Cancer. Clin Cancer Res. 2011 June 1; 17(11): 3716\u20133726. Published online 2011 April 21. doi:\u00a0 10.1158\/1078-0432.CCR-11-0233\u00a0<strong><sup>*<\/sup><\/strong>Corresponding authors.<\/p>\n<p>Nick AM, Stone RL, Armaiz-Pena G, Ozpolat B, Tekederli I, Graybill WS, Landen CN, Villares G,\u00a0<strong>Vivas-Mejia P<\/strong>, Bottsford-Miller J, Kim HS, Lee JS, Kim SM, Baggerly KA, Ram PT, Deavers MT, Coleman RL, Lopez-Berestein G, Sood AK.\u00a0 Silencing of p130cas in Ovarian Carcinoma: A Novel Mechanism for Tumor Cell Death.\u00a0 J Natl Cancer Inst. 2011. doi: 10.1093\/jnci\/djr372. Epub 2011 Sep 28.<\/p>\n<p>Chakravarty D, Roy SS, Ram Babu C, Dandamudi R, Curiel TJ,\u00a0<strong>Vivas-Mejia P<\/strong>, Lopez-Berestein G,\u00a0 Sood AK and Ratna K. Vadlamudi. Therapeutic targeting of PELP1 prevents ovarian cancer growth and metastasis. Clinical Cancer Research, March 2011. doi: 10.1158\/1078-0432.CCR-10-2718. Epub 2011 Mar 18.<\/p>\n<p>Gaur P, Sceusi EL, Samuel S, Xia L, Fan F, Zhou Y, Lu J, Tozzi F, Lopez-Berestein G,\u00a0<strong>Vivas-Mejia P,<\/strong>\u00a0Rashid A, Fleming JB, Abdalla EK, Curley SA, Vauthey JN, Sood AK, Yao JC, Ellis LM.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21806944\">Identification of Cancer Stem Cells in Human Gastrointestinal Carcinoid and Neuroendocrine Tumors.<\/a>\u00a0Gastroenterology. 2011 Nov;141(5):1728-37. Epub 2011 Jul 30.<\/p>\n<p>Stany MP, Vathipadiekal V, Ozbun L, Stone RL, Mok SC, Xue H, Kagami T, Wang Y, McAlpine JN, Bowtell D, Gout PW, Miller DM, Gilks CB, Huntsman DG, Ellard SL, Wang YZ, Vivas-Mejia P,\u00a0<strong>Lopez-Berestein G<\/strong>, Sood AK, Birrer MJ.\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21754983\">Identification of novel therapeutic targets in microdissected clear cell ovarian cancers.<\/a>\u00a0PLoS One. 2011;6(7):e21121. Epub 2011 Jul 6.PMID: 21754983.<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_column_text]Dr. Pablo E. Vivas-Mejia is an assistant professor in the Department of Biochemistry &amp; Cancer Center at the University of Puerto Rico Medical Sciences Campus. Dr. Vivas-Mejia\u2019s major interest areas are to understand the mechanisms by which cancer cells become resistant to chemotherapy and to design and test small interference RNA&hellip;<\/p>\n","protected":false},"featured_media":1096,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[34,26],"class_list":["post-803","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-associate-professors","dt_team_category-faculty","dt_team_category-34","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team\/803","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/comments?post=803"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media\/1096"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/media?parent=803"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/biochemistry\/wp-json\/wp\/v2\/dt_team_category?post=803"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}