{"id":1875,"date":"2022-06-13T09:48:16","date_gmt":"2022-06-13T13:48:16","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/medicine\/?post_type=dt_team&#038;p=1875"},"modified":"2025-11-10T09:33:27","modified_gmt":"2025-11-10T13:33:27","slug":"dr-jose-r-carlo-izquierdo","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/medicine\/dt_team\/dr-jose-r-carlo-izquierdo\/","title":{"rendered":"Dr. Jos\u00e9 R. Carlo Izquierdo"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-118769e05769245e7\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-118769e05769245e7 uvc-5387 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-118769e05769245e7 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Jos\u00e9 R. Carlo Izquierdo<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-118769e05769245e7 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-5afbe1b21a10ba2ffa343458b0bcd40c.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-5afbe1b21a10ba2ffa343458b0bcd40c.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-5afbe1b21a10ba2ffa343458b0bcd40c .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-5afbe1b21a10ba2ffa343458b0bcd40c .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-5afbe1b21a10ba2ffa343458b0bcd40c alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/medicine\/wp-content\/uploads\/sites\/15\/2022\/06\/jose-carlo.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/medicine\/wp-content\/uploads\/sites\/15\/2022\/06\/jose-carlo.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/medicine\/dt_team\/dr-jose-r-carlo-izquierdo\/jose-carlo\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Jos\u00e9 Carlo Izquierdo\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-1879\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-1879 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"jose.carlo@upr.edu\">jose.carlo@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6901\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6901 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">University District Hospital<\/span><br \/>\n<span style=\"color: #ffffff;\">Neurology Section, 5th Floor<\/span><br \/>\n<span style=\"color: #ffffff;\">School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR 00936<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-4180\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-4180 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787-754-0101, Ext. 2516<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><p><span style=\"color: #ffffff;\">Degree: M.D. UPR, School of Medicine, 1978<\/span><\/p>\n<p><span style=\"color: #ffffff;\">UPR, Pre-Med-Special Advanced Placement Program- 1972-974<\/span><\/p>\n<p><span style=\"color: #ffffff;\">INTERNSHIP: Charity Hospital, New Orleans, Louisiana State University, 1978-79<\/span><\/p>\n<p><span style=\"color: #ffffff;\">RESIDENCY: Neurology, Louisiana State University, 1979-1982<\/span><\/p>\n<p><span style=\"color: #ffffff;\">FELLOWSHIP: Neuromuscular Diseases, University of Southern California Neuromuscular Center (W.K. Engel, Director), 1982-83<\/span><\/p>\n<p><span style=\"color: #ffffff;\">SPECIALTY: Neurology<\/span><\/p>\n<p><span style=\"color: #ffffff;\">SUBSPECIALTY: Neuromuscular Diseases, Electrodiagnostic Medicine, Pain Medicine<\/span><\/p>\n<\/div><div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2216\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"fas fa-book\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2216 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/md.rcm.upr.edu\/medicine\/wp-content\/uploads\/sites\/15\/2022\/06\/CV-Jose-R.-Carlo-Izquierdo.pdf\">CV<\/a><\/span><\/span><\/div><\/li><\/ul><\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-775269e0576925501\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-775269e0576925501 uvc-4183  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-775269e0576925501 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">ACADEMIC POSITIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-775269e0576925501 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Professor, (Neurology), UPR, School of Medicine 2001- present,<\/p>\n<p>Associate Professor, UPR, School of Medicine 1994-2001.<\/p>\n<p>Assistant Professor, UPR, School of Medicine 1986-1994.<\/p>\n<p>Assistant Professor, Neuropediatric Section, San Juan, City Hospital, 1984-1994<\/p>\n<p>Associate Director, Neurology Training Program, UPR, School of Medicine, 1988-1992.<\/p>\n<p>Chancellor, UPR, Medical Sciences Campus, July 2002-September 2009.<\/p>\n<p>Acting Chancellor, UPR, Medical Sciences Campus, March 2001- July 2002.<\/p>\n<p>Member, University of Puerto Rico Administrative Board, March 2001-2009.<\/p>\n<p>Clinical Instructor, University of Southern California, School of Medicine, 1982-1983<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-213569e0576925558\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-213569e0576925558 uvc-7544  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-213569e0576925558 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">GRANTS &amp; PROJECTS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-213569e0576925558 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">PI Carlo, J<br \/>\nOn-going<\/p>\n<p>University of Puerto Rico Medical Sciences Campus, Patient Services, Muscular Dystrophy Association &#8220;MDA Care Center&#8221; Grant, Muscular Dystrophy Association, Grant Period 2016-2019.<\/p>\n<p>PI: Carlo, Jose R.<\/p>\n<p>Longitudinal Study of the Relationship between Impairment, Activity Limitation, Participation and Quality of Life in Persons with Confirmed Duchenne Muscular Dystrophy (DMD). Cooperative Internation Neuromuscular Research Group (CINRG). Funded DOD, Muscular Dystrophy Association. Completed.<\/p>\n<p>Clinical Trial of Coenzyme Q 10 and ACE Inhibitors in Duchenne Muscular Dystroph. Cooperative Internation Neuromuscular Research Group (CINRG). Funded DOD, Muscular Dystrophy Association. Completed.<\/p>\n<p>3. Tadalafil in Duchenne Muscular Dystrophy, Sponsor Eli Lilly, 2014-on going, Clinical Trial, PI- site director.<\/p>\n<p>PI Carlo, J<\/p>\n<p>.5G12RR003051-22<\/p>\n<p>RCMI Multidisciplinary Collaborative Research Program NATIONAL CENTER FOR RESEARCH RESOURCES 01-SEP-1997\/31-JUL-2011<\/p>\n<p>The proposed goal of the Program for the next five years is to continue the development of competitive research on the Medical Sciences Campus, by focusing on the development of a strong infrastructure for conducting multidisciplinary collaborative research studies through the establishment of clusters of excellence in health disparities affecting the Puerto Rican population, minority institution research support<\/p>\n<p>m Carlo, J 5P20RR011126-13<br \/>\n30-SEP-1997\/30-JUN-2010<br \/>\nMedical Sciences Campus Clinical Research Development NATIONAL CENTER FOR RESEARCH RESOURCES<\/p>\n<p>Capacity Building and Infrastructure support for Clinical Research. Support for the RCMI Clinical Research center at the University of Puerto Rico Medical Sciences Campus.<\/p>\n<p>m Carlo, J<br \/>\n5S21MD001830-03<br \/>\n30-SEP-2005\/31-AUG-2008<\/p>\n<p>NATIONAL CENTER ON MINORITY HEALTH AND HEALTH DISPARITIES<\/p>\n<p>Capacity Advancement in Research Infrastructure: U Puerto Rico School of Dentistry<\/p>\n<p>The goal of this is to advance (via stable endowment funding) the health disparities research infrastructure and capacity of the University of Puerto Rico School of Dentistry (UPRSD) and the Graduate School of Public Health (UPRGSOPH) for the conduct, collaboration, and promotion of scientifically meritorious research on Health Disparities, while developing the &#8220;pipeline&#8221; of new minority researchers.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-50569e05769255a2\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-50569e05769255a2 uvc-8773  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-50569e05769255a2 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-50569e05769255a2 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">A phase 3 randomized placebo-controlled trial of tadalafil for Duchenne muscular dystrophy: Victor RG, Sweeney HL, Finkel R, McDonald CM, Byrne B, Eagle M, Goemans N, Vandenborne K, Dubrovsky AL, Topaloglu H, Miceli MC, Furlong P, Landry J, Elashoff R, Cox<\/p>\n<p>D; Tadalafil DMD study Group.Neur010gy. 2017 Oct \u00a0T 811-1820 doi: 10.1212\/WNL.0000000000004570. Epub 2017 sep 29. PMID: 28972192 As Co-investigator with the CINRG (Cooperative International Neuromuscular Research Group<\/p>\n<p>TCTEXIDI is a genetic modifier of disease progression in Duchenne muscular dystrophy.<\/p>\n<p>Spitali PI, ZaharievqJ2, Bohringu_$3, Hiller M4, Chaouch A5,6, Roos A5, Scotton C7, Claustres M8, Bello L9,10,<\/p>\n<p>McDonald CMI 1, Hoffman EP9; CINRG Investigators, Koeks Z12, Eka Suchiman H13, Cirak \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 Scoto<\/p>\n<p>Ml 4, Reza M5, Hoen PAC4, Niks EH 12, TuffelY-Giraud S8, Lochmiifler H5, 17,18, Feriini Al, Muntoni FM, 19, Aartsma-Rus A4,5. Eur J Hum Genet. 2020 Jan 2. doi: 10.10381s41431-019-0563-6.<\/p>\n<p>Towards regulatory endorsement of drug development tools to promote the application of model-informed drug development in Duchenne muscular dystrophy. Conrado DJ, et al; Duchenne Muscular Dystrophy Regulatory Science Consortium (D-RSC). J Pharmacokinet<\/p>\n<p>Pharmacodyn. 2019 May 24. doi: 10.1007\/s10928-019\u201e09642-7. [Epub ahead of print] PMID.\u2022 31127458<\/p>\n<p>Longitudinal pulmonary function testing outcome measures in Duchenne muscular dystrophy: Long-term natural history with and without glucocorticoids.<\/p>\n<p>McDonald CMI, Gordish-Dressman H2, Henricson EK3, Duong T4, Joyce NC3, Jhawar S3, Leinonen M5, Hsu F2, Connolly AM6, Cnaan A2, Abresch RT3; CINRG investigators fox PubMed. Neuromuscul Disord. 2018 \u00a0doi: 10.1016\/j.nmd.2018.07.004. Epub 2018 Aug 29.<\/p>\n<p>Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study.<\/p>\n<p>McDonald CMI, Henricson EK2, Abresch RT2, Duong T3, Joyce NC2, Hu F4, Clemens PR5, Hoffman EP6, Cnaan A4, Gordish-Dressman H4; CINRG Investi ators. Lancet. 2018 Feb \u00a0doi: 10.1016\/S014067360 7)32160-8. Epub 2017 Nov 22.<\/p>\n<p>Evidence for ACTN3 as a genetic modifier of Duchenne muscular dystrophy.<\/p>\n<p>Hoganh MW1,2, Houweling PJI \u00a0 Thomas KCI, Gordish-Dressman H6, Bello L6,7\u2022, Cooperative International Neuromuscular Research Groum(CJNRG), Pegoraro E7, Hoffman<\/p>\n<p>EP6, I-lead S13, North IQ, Nat Commun. 2017 Jan \u00a0PMID: 28139640 PMCID: PMC5290331 DOI: 10.1038\/ncomms14143<\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1983,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[36,47],"class_list":["post-1875","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-neurology","dt_team_category-36","dt_team_category-47","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/dt_team\/1875","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/comments?post=1875"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/media\/1983"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/media?parent=1875"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/medicine\/wp-json\/wp\/v2\/dt_team_category?post=1875"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}