Edmundo N. Kraiselburd, Ph.D.
- M.S. Nuclear Physics, Universidad de Buenos Aires, 1965
- M.S. Molecular Biology, State Univ. of New York at Buffalo, 1971
- Ph.D. Virology, State Univ. of New York at Buffalo, 1973
Professor & Director, SNRP NeuroAIDS Research Program.
Academic Address, Telephone & E-Mail:
Department of Microbiology and Zoology
University of Puerto Rico – School of Medicine
P.O. Box 365067, San Juan, Puerto Rico 00936-5067
Phone: (787) 758-2525 Ext. 1324
Direct: (787) 764-4325 / (787) 777-0079
Fax: (787) 777-0078
Field of Interest:
Basic Research in SIV/HIV:
- Evaluation Studies of a DNA Vaccine Expressing SIVsm VLP: The long term objective of this research is to develop a vaccine capable of inducing protective immune responses in rhesus macaques against pathogenic simian immunodeficiency virus (SIV). For this purpose, we are evaluating the immune responses generated in macaques by different SIV DNA vaccine candidates (Vec B7). The 1.6Kb deletion (pol,vif,vpr,and vpx) of SIVsm87 provirus DNA was introduced into the SIVsmH4 DNA to construct the Vec B7 expression vector. Vec B7 expressed SIVsm gag, env and nef proteins, produced virus-like particles (VLP) in vitro, and was immunogenic in mice. This project was supported by several grants , including R01 AI 44592 from NIH (NIAID).
- Cellular innate activation as a tactic to prevent HIV-1 transmission – Role:PI
The major goal of this project is to understand correlates of lack of HIV infection in women known to be exposed to the virus AIDS by their behavior and to determine if a particular immune response (specific innate immunity) is over-represented in them. We are testing the impact of the targeting the selective
activation of the candidate innate response in non-human primates to be infected with SIV to obtain direct data as to whether this response will decrease viral transmission when activated locally. Supported by 1R01AI084142-01 from NIH/NIAID. 09/12/09-08/31/11- $1,558,403
- Early lnnate llgA Anti-HIV/SIV Response in Exposed Uninfected.
Role: PI .The objective of this grant is to develop an animal model to study natural resistance to HIVISIV infection . Our aim is to determine possible mechanisms that prevent SIVIHIV infection in highly exposed individuals. We want to determine if repeated cervico-vaginal exposures of rhesus macaques to non infectious SIV E660 particles (SIVsm B7 VLP) induce a persistent innate cellular infiltrate (plasmacytoid DCs, NK, macrophages) that in combination with mucosal SlV-specific lgA antibody levels decreases mucosal infectivity to SIV mac251. This proposal represents a collaborative effort between The University of Puerto Rico, Nebraska University, University of Minnessota,
Duke University, University of Massachusetts,Tulane University, National Cancer Institute,and The Wistar Institute. Supported by 1R01AI094603 from NIAID, NIH; 04/01/11-03/31/17.
- A Caribbean project for clinical and basic neuroscience research. Role Pl. This translational research grant consisted of various subprojects, centered in NeuroAIDS. The major goal of this proposal is to help develop the NeuroAIDS Research Infrastructure at the UPR Medical Sciences Campus. Supported by U54 NS043011-06 from NINDS, NIH . $11,354,088
Participated as PI of the following grants :
- CARIBBEAN PRIMATE RESEARCH CENTER: The major goal of this project is to maintain and enhance the Caribbean Primate Research Center basic infrastructure, which is needed for the support of several biomedical research initiatives of national interest and local research projects. This program is currently supported by a P40 RR03640 grant from NCRR (NIH);12/01110-11/30/15 – $11,401,279.
- CPRC SPF Rhesus Monkey Program: This program is currently supported by two different grants from NCRR (NIH): U42 RR16021 and U24 RR18108. The major goal of these two projects is to develop a colony of MHCI and II genetically defined specific pathogen-free rhesus macaques to make them available to investigators supported by NIH and by other federal programs.
Selected peer-reviewed publications (2010-present):
- Rivera-Amil V. Kumar R. Noel Rl. Garcia Y. Rodriguez IV. Martinez .M. Sariol CA. Kraiselburd E. lszard M, Mukherii M, Kumar Giavedoni LD. Kumar A. Short Communication: Lack of Immune Response in Rapid Progressor Morphine-Dependent and SIV/SHIV-Infected Rhesus Macaques Is Correlated with Downregulation ofT(H)1 Cytokines.AIDS Res Hum Retroviruses. 2010 Jul 30. [Epub ahead of print] PMID: 20672973
- Rivera-Ami!! V, Kumar R, Noel RJ Jr, Garcia Y, Rodriguez IV, Martinez M, Sariol CA, Kraiselburd E, lszard M, Mukherji M, Kumar S, Giavedoni LD, Kumar A.Short communication: Lack of immune response in rapid progressor morphine-dependent and SIVISHIV-Infected rhesus macaques is correlated with downregulation ofTH1 cytokines. AIDS Res Hum Retroviruses. 2010 Aug;26(8):919-22. PMID:20672973.
- Carlos A. Sariol, Melween !. Martinez, Francheska Rivera, ldia Vanessa Rodriguez, Petraleigh Pantoja, Kristina Abel, Teresa Arana, Luis Giavedoni, Vida Hodara, Laura J. White, Yesseinia !. Angler6, Luisj. Montaner, Edmundo N.Kraiselburd. Decreased Dengue Replication and an Increased Anti-viral Humoral Response with the use of Combined Toll-Like Receptor 3 and 7/8 Agonists in Macaques. PLoS One. 2011 Apr 29;6(4):e19323. PMID:21559444
- Castro M del R, Suárez E, Kraiselburd E, Isidro A, Paz J, Ferder L, Ayala-Torres S. Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Exp Gerontol. 2012 jan;47(1):29-37.Epub 2011 Oct 12. PMID:22027539
- Rodriguez-Mercado R, Ford GD,Xu Z,Kraiselburd EN,Martinez Ml, Eterovic VA, Colon E, Rodriguez IV, Portilla P, Ferchmin PA, Gierbolini L, Rodriguez-Carrasquillo M, Powell MD,PulliamjV, McCraw CO,Gates A, Ford BD.Acute neuronal injury and blood genomic profiles in a nonhuman primate model for ischemic stroke. Comp Med.2012;62(5):427-38. PMID:23114047.
- Abdulhaqq SA, Martinez MI, Kang G, Foulkes AS, Rodriguez IV, Nichols SM, Hunter M, Sariol CA, Ruiz LA, Ross BN, Yin X, Speicher DW, Haase AT, Marx PA, Li Q, Kraiselburd EN, Montaner LJ. Serial Cervicovaginal Exposures With Replication-Deficient SIVsm Induce Higher Dendritic Cell (pDC) and CD4+ T-Cell Infiltrates Not Associated With Prevention but a More Severe SIVmac251 Infection of Rhesus Macaques. J Acquir Immune Defic Syndr.2014 Apr 1;65(4):405-13. PMID: 24226059  PMCID: PMC3943721 [Available on 2015/4/1] .
- Abdulhaqq, S.A., Zorilla, C., Kang, G., Yin, X., Tamayo, V., Seaton, K., Joseph, J., Garced, S., Sariol, C.A., Tomaras, G., Foulkes, A.S., VerMilyea, M., Coutifaris, C., Kossenkov, A., Kraiselburd, E.N., Li, Q., Montaner, L.J. 2015. Long-term HIV Seronegative Female Sex Workers Sustain High Cervical IFNε, Low Mucosal/Systemic Immune Activation and Low Gene Expression Required for HIV Infection. Mucosal Immunology. Nov 11. [Epub ahead of print]. PMID: 26555708
- Abdulhaqq, S.A., Martinez, M., Kang, G., Rodriguez, I.V., Nichols, S.M., Beaumont, D., Joseph, J., Azzoni, L., Yin, X., Liu, Q., Foulkes, A., Münch, J., Coutifaris, C., Tomaras, G., Sariol, C., Marx, P.A., Li, Q., Kraiselburd, E.N., Montaner, L.J. 2016. Chronic semen reduces cervico-vaginal SIVmac251 infection in rhesus macaques. In preparation.