{"id":1489,"date":"2021-11-30T10:38:46","date_gmt":"2021-11-30T14:38:46","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/micro\/?post_type=dt_team&#038;p=1489"},"modified":"2021-11-30T11:00:49","modified_gmt":"2021-11-30T15:00:49","slug":"faculty-tmp","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/faculty-tmp\/","title":{"rendered":"faculty-tmp"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#1c1c1c;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#1c5b24;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#1c1c1c\"  data-border_color=\"#1c5b24\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-8c045712d93d5f6d9b132ccec91373fd.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-8c045712d93d5f6d9b132ccec91373fd.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-8c045712d93d5f6d9b132ccec91373fd .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-8c045712d93d5f6d9b132ccec91373fd .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-8c045712d93d5f6d9b132ccec91373fd alignleft  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/dra-adelfa-serrano.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/dra-adelfa-serrano.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-adelfa-e-serrano\/dra-adelfa-serrano\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Adelfa E. Serrano Brizuela\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\">Contact Info<\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-5136\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-5136 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">adelfa.serrano@upr.edu<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6394\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-051\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6394 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Phone Office: 787) 758-2525 ext.: X-1313; (787) 751-9486<\/span><br \/>\n<span style=\"color: #ffffff;\">Phone Lab: (787) 758-2525, X-2217, X-1314<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-4418\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-4418 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Laboratory of Molecular and Cellular Biology of Parasites: Malaria<\/span><br \/>\n<span style=\"color: #ffffff;\">Rm A-310, Rm A-346, Rm A-349<\/span><br \/>\n<span style=\"color: #ffffff;\">Department of Microbiology and Medical Zoology,<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto-Rico-School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067,<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, P.R. 00936-5067.<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\">Office Hours<\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8424\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-clock-01\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8424 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">L-M<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\">Academic Profiles<\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">ORCID: https:\/\/orcid.org\/0000-0001-5929-9973\u00a0\u00a0\u00a0<a style=\"color: #ffffff;\" href=\"https:\/\/www.cienciapr.org\/en\/user\/aserrano\">https:\/\/www.cienciapr.org\/en\/user\/aserrano<\/a><\/span><\/li>\n<li><span style=\"color: #ffffff;\">LINKEDIN:\u00a0<a style=\"color: #ffffff;\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=adelfa+e+serrano&amp;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=adelfa+e+serrano&amp;sort=date<\/a><\/span><\/li>\n<li><span style=\"color: #ffffff;\">Bibliography:\u00a0<a style=\"color: #ffffff;\" href=\"https:\/\/www.researchgate.net\/profile\/Adelfa-Serrano-Phd\">https:\/\/www.researchgate.net\/profile\/Adelfa-Serrano-Phd<\/a><\/span><\/li>\n<li><span style=\"color: #ffffff;\">Scholar:\u00a0<a style=\"color: #ffffff;\" href=\"https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Adelfa+E.+Serrano+Brizuela&amp;btnG\">https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Adelfa+E.+Serrano+Brizuela&amp;btnG<\/a>=<\/span><\/li>\n<\/ul>\n<\/div>[vc_column_text]<span style=\"color: #ffffff;\">Education<\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S. Biology , University of Puerto Rico, R.P., P.R. 1979<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. Biology\/Parasite Immunology, University of Puerto Rico, R.P., P.R. 1981<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph. D. Zoo\/Immunoparasitology, University of Georgia, Dept. of Zoology 1987<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Post-doc Molec. Biol. of Parasites, Harvard School of Public Health, Trop.Pub. Health 1991<\/span><\/li>\n<\/ul>\n<\/div>[vc_column_text]<span style=\"color: #ffffff;\">Curriculum Vitae<\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6258\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"Defaults-book\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6258 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><a href=\"#\"><span style=\"color: #ffffff;\">CV<\/span><\/a><\/span><\/div><\/li><\/ul><\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;2\/4&#8243;]<div id=\"ultimate-heading-738469d304acaa9fa\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-738469d304acaa9fa uvc-843 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-738469d304acaa9fa h2'  data-responsive-json-new='{\"font-size\":\"desktop:50px;mobile_landscape:34px;\",\"line-height\":\"desktop:60px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Adelfa E. Serrano<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-738469d304acaa9fa .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:24px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[vc_empty_space][vc_column_text]<strong>RESEARCH INTEREST<\/strong><\/p>\n<p>Our research is focused on genes from the glutathione biosynthesis and recycling pathway and those encoding ABC transporter proteins. These genes were previously associated to antimalarial resistance. Our approach to study this phenomenon is a combination of molecular and cellular biology techniques using Plasmodium berghei, which is a powerful rodent model for in vivo analyses. Following disruption of the genes of interest, both individually and in combination (double knockouts), phenotypical analyses including parasite development within the vertebrate (mouse) and invertebrate (mosquito) hosts are performed. In addition, sensitivity profiles to various anti-malarial drugs are determined both in vitro and in vivo. These studies contribute to a more comprehensive understanding of the oxidative stress coping mechanisms mediated by GSH and the role of ABC transporter proteins in parasite development providing new avenues for the development of novel antimalarial intervention strategies.<\/p>\n<p>Additional research interests include in vivo drug testing of antimalarial compounds as part of collaborative efforts.[\/vc_column_text][vc_column_text]<strong>PUBLICATIONS<\/strong><\/p>\n<ul>\n<li>Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jim\u00e9nez-D\u00edaz MB, Mag\u00e1n N, Gomez V, Ferrer S, Santos Mart\u00ednez M, Wittlin S, Papastogiannidis P, O\u2019Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E. Aminoindoles: a Novel Scaffold with Potent Activity against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Mar 21. [Epub ahead of print]<\/li>\n<li>Gerena Y, Gonzalez-Pons M and Serrano AE. Cytofluorometric Detection of Rodent Malaria Parasites Using Red-Excited Fluorescent Dyes. Cytometry Part A (In press)<\/li>\n<li>Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodriguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE. 2010. Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.J Biol Chem. 2010 Jun 23. PMID: 20573956<\/li>\n<li>Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Bir Sidhu A, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Krespo Llado KN, Serrano AE, Angulo-Barturen I, Jimenez-Diaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E. 2010. Novel inhibitors of plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model. J Biol Chem. 2010 Aug 11. PMID: 20702404<\/li>\n<li>Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R. 2010. A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent in vivo Antimalaria Activity. Org Lett. 2010 Aug 18. PMID: 20718474<\/li>\n<li>Col\u00f3n-Lorenzo EE, Serrano AE, Nicholas Jr. HB, Wymore T, Ropelewski AJ, Gonz\u00e1lez-M\u00e9ndez R. The Plasmodium glutathione S-transferase: Bioinformatics Characterization and Classification into the Sigma Class. (2010). In: Fred A, Filipe J, Gamboa H, editors. Proceedings of Bioinformatics 2010, 1st International Conference on Bioinformatics, pp 173-180. Lisbon, Portugal, ISBN: 978-989-674-019-1 (PMID in process)<\/li>\n<li>Vega-Rodr\u00edguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodr\u00edguez-Orengo JF, Jacobs-Lorena M, and Serrano AE. 2009. The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission. PLoS Pathog. Feb;5(2):e1000302. PMID: 19229315.<\/li>\n<li>Gonzalez-Pons M, Szeto AC, Gonzalez-Mendez R, and Serrano AE. 2009. Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei. Malar J. Jan 2;8(1):1. [PMID: 19118502.14<\/li>\n<li>Ferrer-Rodr\u00edguez, I., J. P\u00e9rez-Rosado, G. W. Gervais, W. Peters, B.Robinson and A.E.Serrano. 2004. Plasmodium yoelii: identification and partial characterization of an mdr1 gene in an artemisinin resistant line. Journal of Parasitol. 90 (1):<\/li>\n<li>Szeto, A.C., J. P\u00e9rez-Rosado, I. Ferrer-Rodr\u00edguez, J. Vega, C. Torruella-Thillet and A.E.Serrano. 2003. Identification and expression analysis of ABC genes in Plasmodium yoelii and Plasmodium berghei. Parasitol. Research. Oct.17<\/li>\n<li>P\u00e9rez-Rosado, J., G. W. Gervais, Ferrer-Rodr\u00edguez, I., W. Peters, and A. E. Serrano. 2002. Plasmodium berghei: Analysis of the gamma-glutamylcystheine synthetase gene in drug resistant lines. Exp.Parasitol. 101: 175-182.<\/li>\n<li>Ferrer-Rodr\u00edguez, I., J. P\u00e9rez Rosado, and A.E. Serrano. 2000. \u201cEl Diagn\u00f3stico de la Malaria\u201d. Revista Oficial Colegio Tecn\u00f3logos M\u00e9dicos. 16(2):6-10.<\/li>\n<li>Carrasquillo, G., M. Banguero, P. S\u00e1nchez, F. Carvajal. R. H. Barker Jr., G. Gervais, E. Algar\u00edn and A.E. Serrano. 2000. Epidemiological tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast. American Journal of Tropical Medicine &amp; Hygiene 62(1): 132-137.<\/li>\n<li>Ferrer-Rodr\u00edguez, I., G. V\u00e1zquez, J. C\u00f3rdova, and A.E. Serrano. 1999. Diagnosis of malaria by Polymerase Chain Reaction. Puerto Rico Health Sci. Journal. 18(2):99-103.<\/li>\n<li>A.E. Serrano, B.L. Robinson, W.A. Peters, and K. Trujillo-Nev\u00e1rez. 1999. Plasmodium berghei and Plasmodium yoelii: molecular karyotypes of drug resistant lines. Experimental Parasitol. 91:93-96<\/li>\n<li>Gervais, G., K. Trujillo-Nev\u00e1rez, B.L. Robinson, W. A. Peters and A.E. Serrano. 1999. Plasmodium berghei: Identification of an mdr-like gene associated with drug resistance. Exp. Parasitol. 91:86-92.<\/li>\n<li>Ramajo Martin, V., L\u00f3pez Aban, J., A.E. Serrano, A. Oleaga P\u00e9rez and A. Muro Alvarez. 1996. A long term study on the prevalence of gastrointestinal, hepatic and pulmonary parasitism in sheep from Salamanca province, Western Spain. Research &amp; Review in Parasitology. 56:173-177.<\/li>\n<li>Ramajo Martin, V., L\u00f3pez Aban, J., A.E. Serrano, A. Oleaga P\u00e9rez and A. Muro Alvarez. 1995. A long term study on the prevalence of gastrointestinal, hepatic and pulmonary parasitism in adult cattle from Salamanca province, Western Spain. Research &amp; Review in Parasitology. 55:231-234.<\/li>\n<li>Wirth, D.F., C. Wilson, A.E. Serrano, A. Wasley, M.P. Bogenschutz, and A.H. Shankar. 1990. Amplification of a gene related to mammalian MDR genes in drug-resistant Plasmodium falciparum. In Parasites: Molecular biology, drug and vaccine design. Wiley-Liss, Inc. 335-347.<\/li>\n<li>Wilson, C.M., A.E. Serrano, A. Wasley, M.P. Bogenschutz, A. H. Shankar and D.F. Wirth. 1988. Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science 244:1185-1186.<\/li>\n<li>Hillyer, G.V. and A.E. Serrano. 1986. Fractionation of Fasciola hepatica tegument antigens and their application to the serodiagnosis of experimental fascioliasis by the enzyme-linked immunosorbent assay. J. Helminth 60: 173-178.<\/li>\n<li>Hillyer, G.V. and A.E. Serrano. 1983. The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani. Am.J. Trop. Hyg. 32: 350-358.<\/li>\n<li>Hillyer, G.V. and A.E. Serrano. 1982. Cross-protection in infections due to Schistosoma mansoni using tegument antigens of Fasciola hepatica. J. Infec. Dis. 145: 728-732.<\/li>\n<\/ul>\n<p>[\/vc_column_text][vc_column_text]<\/p>\n<div class=\"uvc-main-heading ult-responsive\" data-ultimate-target=\".uvc-heading.ultimate-heading-727061a6362bc9304 h3\" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\">\n<h3>Book Chapters<\/h3>\n<\/div>\n<div class=\"uvc-sub-heading ult-responsive\" data-ultimate-target=\".uvc-heading.ultimate-heading-727061a6362bc9304 .uvc-sub-heading \" data-responsive-json-new=\"{&quot;font-size&quot;:&quot;&quot;,&quot;line-height&quot;:&quot;&quot;}\">\n<ul>\n<li>Anti-protozoan drugs. A. Muro, A.E. Serrano,and J.L. P\u00e9rez de Arellano. Chapter 22, pp. 331-343.<\/li>\n<li>Anti-helminthic drugs. A. Muro, A.E. Serrano,and J.L. P\u00e9rez de Arellano. Chapter 23, pp. 345-353.<\/li>\n<\/ul>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][vc_column width=&#8221;1\/4&#8243;][vc_wp_custommenu nav_menu=&#8221;3&#8243;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;2\/4&#8243;][vc_empty_space][vc_column_text]RESEARCH INTEREST Our research is focused on genes from the glutathione biosynthesis and recycling pathway and those encoding ABC transporter proteins. These genes were previously associated to antimalarial resistance. Our approach to study this phenomenon is a combination of molecular and cellular biology techniques using Plasmodium berghei, which is a powerful&hellip;<\/p>\n","protected":false},"featured_media":1173,"comment_status":"open","ping_status":"closed","template":"","dt_team_category":[],"class_list":["post-1489","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team\/1489","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=1489"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/1173"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=1489"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team_category?post=1489"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}