{"id":1532,"date":"2022-01-24T08:13:45","date_gmt":"2022-01-24T12:13:45","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/micro\/?post_type=dt_team&#038;p=1532"},"modified":"2023-02-06T11:47:58","modified_gmt":"2023-02-06T15:47:58","slug":"dr-yisel-m-cantres-rosario","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-yisel-m-cantres-rosario\/","title":{"rendered":"Dr. Yisel M. Cantres Rosario"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-92169eb6bd411dca\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-92169eb6bd411dca uvc-5349 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-92169eb6bd411dca h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Yisel Cantres Rosario<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-92169eb6bd411dca .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Assistant\u00a0 Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-5bfb1489a04866ee87ea8aa35fcbc19d.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-5bfb1489a04866ee87ea8aa35fcbc19d.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-5bfb1489a04866ee87ea8aa35fcbc19d .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-5bfb1489a04866ee87ea8aa35fcbc19d .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-5bfb1489a04866ee87ea8aa35fcbc19d alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2022\/01\/yisel-cantres.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2022\/01\/yisel-cantres.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-yisel-m-cantres-rosario\/yisel-cantres\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Yisel Cantres Rosario, PhD\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-5531\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-5531 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:yisel.m.cantres@upr.edu\">yisel.m.cantres@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-5978\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-5978 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Comprehensive Cancer Center, Lab 332 (Wojna Lab)<\/span><br \/>\n<span style=\"color: #ffffff;\">Department of Microbiology and Medical Zoology,<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto-Rico-School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067,<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, P.R. 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-1407\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-1407 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">(787) 758-2525, X-2819<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><p><span style=\"color: #ffffff;\">\u2022 B.S. Biology, Univ. of Puerto Rico, R\u00edo Piedras, P.R. 2005<\/span><br \/>\n<span style=\"color: #ffffff;\">\u2022 Ph. D. Microbiology and Medical Zoology, Univ. of Puerto Rico, Medical Sciences, P.R. 2016<\/span><br \/>\n<span style=\"color: #ffffff;\">\u2022 Post-doc Mechanisms of HIV-associated neuronal dysfunction, Univ. of Puerto Rico, Medical Sciences, 2018<\/span><br \/>\n<span style=\"color: #ffffff;\">\u2022 Post-doc Monocyte immune responses in neurodegenerative disorders, Univ. of Puerto Rico, Medical Sciences<\/span><\/p>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-494169eb6bd4140da\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-494169eb6bd4140da uvc-9027  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-494169eb6bd4140da h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">ACADEMIC PROFILES<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-494169eb6bd4140da .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>ORCID<\/strong>: https:\/\/orcid.org\/0000-0002-0630-5695<br \/>\n<strong>LINKEDIN<\/strong>:\u00a0https:\/\/www.linkedin.com\/in\/yisel-cantres-rosario-920a36142\/<br \/>\n<strong>NCBI Bibliography<\/strong>:\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1bihwfvwsqBAT\/bibliography\/public\/\">https:\/\/www.ncbi.nlm.nih.gov\/myncbi\/1bihwfvwsqBAT\/bibliography\/public\/<\/a><br \/>\n<strong>ResearchGate<\/strong>: https:\/\/www.researchgate.net\/profile\/Yisel-Cantres-Rosario<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-452669eb6bd414132\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-452669eb6bd414132 uvc-7983  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-452669eb6bd414132 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-452669eb6bd414132 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Chronic inflammation affects people living with HIV (PHW) and leads to the development of HIV-related and non-HIV-related comorbidities including metabolic syndrome, cardiovascular disease, opportunistic infections, HIV-associated neurocognitive disorders (HAND), among others. HAND is of special concern because it affects 20-50% of HIV-positive patients despite the efficacy of modern combined antiretroviral therapy (cART) and improved quality of life, and there are no effective therapies available. Some mechanistic aspects associated with HAND include increased peripheral monocyte and macrophage activation; secretion of pro-inflammatory cytokines, chemokines, and viral proteins; invasion of HIV-infected cells, and proinflammatory factors into the central nervous system (CNS); infection of microglia; activation of CNS resident cells; and neuronal injury. The specific roles of peripheral monocytes\/macrophages (M\u03c6s) in the neuropathogenesis of HIV are not fully understood. Our research project aims to determine how dysregulation of the innate immune responses in M\u03c6s contribute to inflammation, neuronal dysfunction, and cognitive impairment in PWH. We are establishing human 3D brain organoids co-cultured with patient-derived monocytes, to model immune cell invasion to the CNS and study monocyte-neuron interactions <em>in vitro<\/em>. Our approach includes a combination of several techniques including: flow cytometry, immunoassays, single-cell RNA sequencing, and CRISPR\/Cas9, to characterize monocyte populations, neuronal damage markers and disrupted signaling mechanisms. We will expand the brain organoids techniques to study other neurodegenerative diseases, such as Alzheimer\u2019s disease, and develop additional 3D cultures, as part of our collaborations.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-757069eb6bd414178\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-757069eb6bd414178 uvc-3417  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-757069eb6bd414178 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-757069eb6bd414178 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li><strong>Cantres-Rosario YM<\/strong>, Ortiz-Rodr\u00edguez SC, Santos-Figueroa A, Plaud M, Negron K, Cotto B, Langford TD and Melendez LM. (2019) <em>HIV Infection Induces Extracellular Cathepsin B Uptake By Neurons, Triggering Apoptosis And Synapse Loss<\/em>. Scientific Reports 9:8006. doi: 10.1038\/s41598-019-44463-1<\/li>\n<li>Rosas-Vidal LE, Lozada V, <strong>Cantres-Rosario YM<\/strong>, Vega-Medina A, Melendez L, and Quirk GJ. (2018) <em>Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance<\/em>. Neuropsychopharmacology. doi:10.1038\/s41386-018-0176-8<\/li>\n<li><strong>Cantres-Rosario YM, Acevedo-Mariani FM<\/strong>, Perez-Laspiur J, Haskins WE, Plaud M, Cantres Y, Skolasky R, Mendez-Bermudez I, Wojna V, Melendez LM. (2017) Microwave &amp; Magnetic Proteomics of Macrophages from Patients with HIV-Associated Cognitive Impairment. <em>PLoS ONE<\/em> Jul 26;12(7): e0181779. PMID: 28746408.<\/li>\n<li>Mart\u00ednez-Rivera FJ, P\u00e9rez-Laspiur J, Santiago-Gascot ME, Alem\u00e1n-Reyes AG, Garc\u00eda-Santiago E, Rodr\u00edguez-P\u00e9rez Y, Calo-Guadalupe C, Otero-Pag\u00e1n I, Ayala-Pag\u00e1n RN, Mart\u00ednez M, <strong>Cantres-Rosario YM<\/strong>, Mel\u00e9ndez LM, Barreto-Estrada JL. (2017) Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS ONE Jul 18;12(7): e0180409. PMID: 28719635.<\/li>\n<li><strong>Cantres-Rosario YM<\/strong>, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer S, <em>et al.<\/em> (2015) Interacting partners of macrophage-secreted cathepsin B contribute to HIV-induced neuronal apoptosis. <em>AIDS<\/em>: 29:1. PMCID: PMC4636939<\/li>\n<li>Zen\u00f3n F, <strong>Cantres-Rosario Y<\/strong>, Adiga R, Gonzalez M, Rodriguez-Franco E, Langford D, <em>et al. <\/em>(2015) HIV-infected microglia mediate cathepsin B-induced neurotoxicity. <em>J Neurovirol<\/em>, 21(5):544-58. PMCID: PMC4618197<\/li>\n<li>Rivera LE, Col\u00f3n K, <strong>Cantres-Rosario YM<\/strong>, Zen\u00f3n FM, Mel\u00e9ndez LM (2014) Macrophage Derived Cystatin B \/ Cathepsin B in HIV Replication and Neuropathogenesis: 111\u2013120. PMCID: PMC4122617<\/li>\n<li><strong>Cantres-Rosario YM<\/strong>, Plaud-Valent\u00edn M, Gerena Y, Skolasky RL, Wojna V, et al. (2013) Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS 27: 347\u2013356. PMCID: PMC3593054<\/li>\n<li>Rodriguez-Franco EJ, <strong>Cantres-Rosario YM<\/strong>, Plaud-Valentin M, Romeu R, Rodr\u00edguez Y, et al. (2012) Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosis. <em>PLoS ONE<\/em> 7: e36571. PMCID: PMC3365072<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1533,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-1532","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team\/1532","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=1532"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/1533"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=1532"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team_category?post=1532"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}