{"id":809,"date":"2016-03-10T13:36:35","date_gmt":"2016-03-10T17:36:35","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/micro\/?post_type=dt_team&#038;p=809"},"modified":"2024-07-08T18:35:31","modified_gmt":"2024-07-08T22:35:31","slug":"dr-idali-martinez","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-idali-martinez\/","title":{"rendered":"Dr. Idali Martinez"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-434269eb6ce0d87e6\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-434269eb6ce0d87e6 uvc-7042 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-434269eb6ce0d87e6 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Idali Martinez<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-434269eb6ce0d87e6 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-e8b19997ebd321a2bbd48131239492e2.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-e8b19997ebd321a2bbd48131239492e2.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-e8b19997ebd321a2bbd48131239492e2 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-e8b19997ebd321a2bbd48131239492e2 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-e8b19997ebd321a2bbd48131239492e2 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2018\/07\/idali_martinez.png\" data-srcset=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2018\/07\/idali_martinez.png 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/micro\/faculty\/idali_martinez\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Idali Martinez\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-7003\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-7003 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:idali.martinez@upr.edu\">idali.martinez@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3934\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3934 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Department of Microbiology, Room A-355<\/span><br \/>\n<span style=\"color: #ffffff;\">UPR-Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">PO Box 365067<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-9803\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-9803 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><strong>Phone<\/strong>: (787) 758-2525<\/span><\/p>\n<p><span style=\"color: #ffffff;\">Office x 1447<\/span><br \/>\n<span style=\"color: #ffffff;\">Lab: x 1354<\/span><\/p>\n<p><span style=\"color: #ffffff;\"><strong>Fax<\/strong>: (787) 758-4808<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">BS Industrial Microbiology UPR-Mayaguez Campus 1990<\/span><\/li>\n<li><span style=\"color: #ffffff;\">MS Microbiology and Molecular Genetics Rutgers University 1993<\/span><\/li>\n<li><span style=\"color: #ffffff;\">PhD Microbiology and Molecular Genetics Rutgers University 1995<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-893869eb6ce0daed7\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-893869eb6ce0daed7 uvc-7035  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-893869eb6ce0daed7 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">ACADEMIC PROFILES<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-893869eb6ce0daed7 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>ORCID<\/strong>: https:\/\/orcid.org\/0000-0002-0407-0044<br \/>\n<strong>LINKEDIN<\/strong>:\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/idali-martinez-9222783b\/?originalSubdomain=pr\">https:\/\/www.linkedin.com\/in\/idali-martinez-9222783b\/?originalSubdomain=pr<\/a><br \/>\n<strong>Bibliography<\/strong>:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Martinez+Idali\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=Martinez+Idali<\/a><br \/>\n<strong>Researchgate<\/strong>:\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Idali-Martinez\">https:\/\/www.researchgate.net\/profile\/Idali-Martinez<\/a><br \/>\n<strong>Scholar<\/strong>:\u00a0<a href=\"https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Idali-Martinez&amp;btnG\">https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Idali-Martinez&amp;btnG<\/a>=<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-195069eb6ce0daf32\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-195069eb6ce0daf32 uvc-2805  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-195069eb6ce0daf32 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-195069eb6ce0daf32 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Infection with Dengue viruses (DENV) has become a major public health problem in the tropics and an emerging threat for the United States. There are 4 serotypes of this virus that cause diseases ranging widely in severity, from self-limited dengue fever (DF) to potentially fatal dengue hemorrhagic fever-dengue shock syndrome (DHF\/DSS). Currently, no licensed vaccine is available to prevent DENV infections. Thus, the main goal of our laboratory is to develop an effective tetravalent DENV vaccine. Toward this effort, we have developed expression vectors encoding prM\/env genes of all four DENV serotypes. Several of these vectors have been tested as vaccine candidates in mice and one vaccine candidate was also evaluated in non-human primates. We are currently evaluating vaccine candidates against DENV-1 and DENV-3. We also attempt to identify biomarkers for the early detection of patients at risk of developing DHF.<\/p>\n<p>Upon the introduction of West Nile virus (WNV) in the Americas and the Caribbean, we initiated a pilot study to test if prior immunity to DENV can protect Balb\/c mice against morbidity and mortality induced by West Nile virus (WNV) infection. If cross-protection is achieved, this project will allow us to determine the type and duration of the immune responses that may correlate with protection, which is important to improve the design of broad spectrum vaccines that could potentially protect against both pathogens, DENV and WNV.<\/p>\n<p><strong>Research Support:<\/strong><\/p>\n<ul>\n<li>RCMI pilot project G12RR03051, 08\/01\/06-07\/31\/08, Characterization of the immune response and outcome of sequential flavivirus infections in the mouse mode<\/li>\n<li>R21 AI055814-01, 08-01-2003 to 07-31-2006, Evaluation Studies of a Dengue-2 DNA Vaccine in Monkeys<\/li>\n<li>MBRS-SCORE S06-GM008224, 09-01-00 to 07-31-04, Evaluation Studies of a Dengue-2 Envelope DNA Vaccine<\/li>\n<li>Center for Clinical Research, UPR-Medical Sciences Campus, 01\/15\/04 to 07\/31\/05, Identification of biomakers for early stages of the Dengue infection<\/li>\n<li>Internal Caribbean Primate Research Center funding<\/li>\n<\/ul>\n<p><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-698569eb6ce0daf79\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-698569eb6ce0daf79 uvc-6850  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-698569eb6ce0daf79 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-698569eb6ce0daf79 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>X. Mercado; Y. Rivera; E. Hunsperger and I. Martinez. Cross-Protection against West Nile in Dengue-immunized mice was not mediated by virus neutralizatioSubmitted to Virology<\/li>\n<li>M.Rodriguez-Gonzalez, M.Beltran, JL.Mu\u00f1oz-Jord\u00e1n and I.Mart\u00ednez. Polyethyleneimine Enhances the Immunogenicity of a Dengue-4 prM\/Env DNA Vaccine Candidate. Submitted to Virus Research<\/li>\n<li>M.E. P\u00e9rez-V\u00e9lez, T.Garc\u00eda-Nieves, C.Col\u00f3n-S\u00e1nchez, and I.Mart\u00ednez. Induction of neutralization antibodies in mice by Dengue-2 envelope DNA vaccines. PRHSJ 28:239-250. Sept. 2009.<\/li>\n<li>E.Rom\u00e1n and I.Mart\u00ednez. Detection of Rotavirus in stool samples of gastroenteritis patients PR Health Sci. 24:179-184, Sept 2005.<\/li>\n<li>M.Carrer, G.J.V\u00e1zquez, R.I.Lebr\u00f3n, X.Mercado, I.Mart\u00ednez, C.O.V\u00e1zquez, M.Sant\u00e9, and I.E.Robledo. The Microbial Etiologies of Diarrhea in Hospitalized Patients from the PR Medical Center Hospitals. PR Health Sci. J 24:41-44. 2005.<\/li>\n<li>E.O\u2019Neill, I.Martinez, F.Villinger, M.Rivera, S.Gascot, C.Colon, T.Arana, M.Sidhu, R.Stout, D.C.Montefiori, M.Martinez, A.A. Ansari, Z.R.Israel, E. Kraiselburd (2002). Protection by SIV VLP DNA prime\/protein boost following mucosal SIV challenge is markedly enhanced by IL-12\/GM-CSF co-administration. J Med Primatol, 31: 217-227.<\/li>\n<li>I.Mart\u00ednez , L.Giavedoni, and E.Kraiselburd (2001). Clone B7 Cells have a Single Copy of SIVsmB7 Integrated in Chromosome 20. Archives of Virology 146:1-7.<\/li>\n<li>E.Kraiselburd, A.Salam\u00e1n, M.Beltr\u00e1n, M.Rivera, J.Oliver, M.Kessler, M.Knezevich, A.Rodriguez, M.Bilska, D.Montefiori and I.Mart\u00ednez (1997). Vaccine evaluation studies of replication-defective SIVsmB7. Cell. and Mol. Biology, 43(7):915-924.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":73,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-809","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team\/809","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=809"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/73"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=809"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team_category?post=809"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}