{"id":810,"date":"2016-03-10T13:37:54","date_gmt":"2016-03-10T17:37:54","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/micro\/?post_type=dt_team&#038;p=810"},"modified":"2025-07-29T11:10:39","modified_gmt":"2025-07-29T15:10:39","slug":"dr-loyda-m-melendez","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-loyda-m-melendez\/","title":{"rendered":"Dr. Loyda M. Mel\u00e9ndez"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-830569ec8c6f15ca0\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-830569ec8c6f15ca0 uvc-4868 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-830569ec8c6f15ca0 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Loyda M. Mel\u00e9ndez, MT, MS, Ph.D.<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-830569ec8c6f15ca0 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-11d1215004a602d8e0b57638b1a6418a.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-11d1215004a602d8e0b57638b1a6418a.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-11d1215004a602d8e0b57638b1a6418a .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-11d1215004a602d8e0b57638b1a6418a .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-11d1215004a602d8e0b57638b1a6418a alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/loyda-melendez.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/loyda-melendez.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-loyda-m-melendez\/loyda-melendez\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Loyda M. Mel\u00e9ndez\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-9106\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-9106 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:loyda.melendez@upr.edu\">loyda.melendez@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6769\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6769 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Department of Microbiology and Zoology,<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico-School of Medicine,<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, P.R. 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8135\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8135 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787) 758-2525 xt 2816 xt Lab 2817<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">S. Medical Technology, University of Puerto Rico, Rio Piedras and Medical Sciences Campus , P.R.1979<\/span><\/li>\n<li><span style=\"color: #ffffff;\">S. Microbiology, University of Georgia, 1981<\/span><\/li>\n<li><span style=\"color: #ffffff;\">D. Exp. Path\/Immunology, Emory University and CDC, Altanta, GA, 1990<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Post-doctoral training in Immunohematology\/Cytometry, Emory University Pathology Dept, Altanta, GA, 1991 ; and in Pediatrics Infectious Diseases: Role of the placenta in HIV transmission, Emory University Pediatrics, Altanta, GA, 1992<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-85869ec8c6f1833c\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-85869ec8c6f1833c uvc-7716  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-85869ec8c6f1833c h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">ACADEMIC PROFILES<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-85869ec8c6f1833c .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>ORCID<\/strong>:\u00a0<a href=\"https:\/\/orcid.org\/my-orcid?orcid=0000-0003-2571-8206\">https:\/\/orcid.org\/my-orcid?orcid=0000-0003-2571-8206<\/a><br \/>\n<strong>LINKEDIN<\/strong>:\u00a0<a href=\"https:\/\/www.linkedin.com\/in\/loyda-melendez-81b8a315\/\">https:\/\/www.linkedin.com\/in\/loyda-melendez-81b8a315\/<\/a><br \/>\n<strong>Bibliography<\/strong>:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/loyda.melendez.1\/bibliography\/41159254\/public\/?sort=date&amp;direction=ascending\">http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/loyda.melendez.1\/bibliography\/41159254\/public\/?sort=date&amp;direction=ascending<\/a><br \/>\n<strong>PubMED <\/strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=melendez-guerrero+LM\">http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/?term=melendez-guerrero+LM<\/a><br \/>\n<strong>Researchgate<\/strong>:\u00a0<u><a href=\"https:\/\/www.researchgate.net\/profile\/Loyda-Melendez\">https:\/\/www.researchgate.net\/profile\/Loyda-Melendez<\/a><br \/>\n<\/u><strong>Scholar<\/strong>:\u00a0<u><a href=\"https:\/\/scholar.google.com\/citations?view_op=new_articles&amp;hl=en&amp;imq=Loyda+Melendez#\">https:\/\/scholar.google.com\/citations?view_op=new_articles&amp;hl=en&amp;imq=Loyda+Melendez#<\/a><br \/>\n<\/u><strong>Translational Proteomics Center<\/strong> : <a href=\"https:\/\/rcmi.rcm.upr.edu\/proteomic-page\">https:\/\/rcmi.rcm.upr.edu\/proteomic-page<\/a><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-284169ec8c6f18392\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-284169ec8c6f18392 uvc-7939  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-284169ec8c6f18392 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">MISSION AND FIELD OF INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-284169ec8c6f18392 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Laboratory Mission<\/strong><\/p>\n<p>To prepare undergraduate and graduate students in the field of Viral Innate Immunity focusing on the role of macrophages in HIV infection and pathogenesis. To apply proteomics to uncover the molecules and signaling pathways activated by viruses (HIV, Zika, SARSCoV2) to find targets for diagnosis and therapy against viral diseases.<\/p>\n<p><strong>Field of Interest:\u00a0<\/strong><\/p>\n<p>Viral Innate Immunity, Neurosciences, and Proteomics<\/p>\n<p><strong>Active collaborations and projects<\/strong><\/p>\n<p><strong>Ongoing Research Support<\/strong><\/p>\n<ul>\n<li>U54MD007600-29 (Fernandez-Repollet, PI) 1.2 cal mo\u00a0 8\/01\/22-7\/31\/2025<br \/>\nRCMI Translational Proteomics Center- Research Capacity Core<br \/>\nThe major goals of this activity are to expand our research core capabilities in Clinical and Basic Science Proteomics that would lead to improved diagnosis and therapeutic monitoring in health disparities.<br \/>\nRole: Activity Director<\/li>\n<li>NCRR-P20 RR016470 Rodriguez-Medina (PD) 1.2 cal mo 8\/01\/21 &#8211; 5\/30\/2026<br \/>\nAdvancement of Biomedical Research Excellence (INBRE)<br \/>\nClinical Proteomics Discovery Core Facility at University of Puerto Rico Medical Sciences Campus provides new resources for the Advancement of Biomedical Research Excellence. This activity provides funds for developing workshops for faculty and students in the island of Puerto Rico.<br \/>\nRole: Core Leader<\/li>\n<\/ul>\n<p><strong>Completed Research Support (Last 5 years)<\/strong><\/p>\n<ul>\n<li>U54MD007600-29 (Fernandez-Repollet 1.2 cal mo 8\/01\/17-7\/31\/2022<br \/>\nRCMI Translational Proteomics Center<br \/>\nThe major goals of this activity are to expand our research core capabilities in Clinical and Basic Science Proteomics that would lead to improved diagnosis and therapeutic monitoring in health disparities.<br \/>\nRole: Activity Directo<\/li>\n<li>UPR\u00a0 0.5 cal mo\u00a0 Melendez (PI) 8\/01\/2020-12\/31\/2021<br \/>\nHost factors associated with COVID-19 disease severity.<br \/>\nThe major goals of this project are to define the genetics determinants and innate defenses impact COVID-19 disease severity.<\/li>\n<li>SC1GM113691-04 (NIGMS) Melendez (PI) \u00a0 6.0 cal mo\u00a0 5\/01\/15-4\/30\/2021<br \/>\nTargeting Monocyte\/macrophage cathepsin B interactome in HIV-1 neurocognitive disorders.<br \/>\nThis project explored the role of neurotoxic proteins from macrophages in the development of HIV-neurotoxicity and their expression in in patients treated with combined antiretroviral therapy or cART. HIV.<\/li>\n<\/ul>\n<p><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-563569ec8c6f183df\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-563569ec8c6f183df uvc-2491  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-563569ec8c6f183df h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Students<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-563569ec8c6f183df .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>PAST AND CURRENT STUDENTS MENTORED IN RESEARCH FACULTY MEMBER<\/strong><\/p>\n<table width=\"100%\">\n<tbody>\n<tr>\n<td width=\"169\"><strong>Name of Past and Current Students<\/strong><\/td>\n<td width=\"138\"><strong>Undergraduate or Graduate Student<sup>1<\/sup><\/strong><\/td>\n<td width=\"150\"><strong>Period of Time Mentored by Faculty Member<sup>2<\/sup><\/strong><\/td>\n<td width=\"156\"><strong>Prior Academic Experience or Degree Earned<sup>3<\/sup><\/strong><\/p>\n<p>Degree\u00a0 Yr Institution<\/td>\n<td width=\"228\"><strong>Student\u2019s Current Support Position or Source of Support<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"169\">\n<h3>Past Students<\/h3>\n<\/td>\n<td width=\"138\"><strong>\u00a0<\/strong><\/td>\n<td width=\"150\"><strong>\u00a0<\/strong><\/td>\n<td width=\"156\"><strong>\u00a0<\/strong><\/td>\n<td width=\"228\"><strong>\u00a0<\/strong><\/td>\n<\/tr>\n<tr>\n<td width=\"169\">1.\u00a0\u00a0\u00a0\u00a0Marin\u00e9s Plaud<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">1993-1996<\/td>\n<td width=\"156\">MS-1996 UPR-MSC<\/td>\n<td width=\"228\">MS Research Associate<\/p>\n<p>UPR-MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">2.\u00a0\u00a0\u00a0 Jessicca Renta<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">1994-1997<\/td>\n<td width=\"156\">MS-1997 UPR-MSC<\/td>\n<td width=\"228\">MS Research Associate-UPR MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">3.\u00a0\u00a0\u00a0 Johana Mel\u00e9ndez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">1996-1998<\/td>\n<td width=\"156\">MS-1998 UPR-MSC<\/td>\n<td width=\"228\">MS Flow Cytometry\u00a0 Assistant Director-Moffit Cancer Center<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">4.\u00a0\u00a0\u00a0 Fernando Soto<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">1994-1995<\/td>\n<td width=\"156\">BS-1995 UPR-Rio Piedras<\/td>\n<td width=\"228\">MD MSC<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">5.\u00a0\u00a0\u00a0 Monica Grafals<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">1995<\/td>\n<td width=\"156\">BS-1998 UPR-Rio Piedras<\/td>\n<td width=\"228\">MD MSC<\/p>\n<p>&nbsp;<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">6.\u00a0\u00a0\u00a0 Gill Nieves<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">1996-1997<\/td>\n<td width=\"156\">BS-1998 UPR-Rio Piedras<\/td>\n<td width=\"228\">MD MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">7.\u00a0\u00a0\u00a0 Zulma Carrasquillo<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">1997<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">PhD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">8.\u00a0\u00a0\u00a0 Robert Bowles<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">1999<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\"><strong>9.\u00a0\u00a0\u00a0 <\/strong>Mariela Agosto<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2000<\/td>\n<td width=\"156\">UPR- Cayey<\/td>\n<td width=\"228\">MBRS<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">10.\u00a0 Yaritza Puig<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2000<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MBRS<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">11.\u00a0 Gisela Torres<\/td>\n<td width=\"138\">Harvard Medical Student<\/td>\n<td width=\"150\">1999-2000<\/td>\n<td width=\"156\">UPR-Mayaguez<\/td>\n<td width=\"228\">M.D. U. Texas<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">12.\u00a0 Zulma S\u00e1nchez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2000-2001<\/td>\n<td width=\"156\">U.de Colombia<\/td>\n<td width=\"228\">U.de Colombia<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">13.\u00a0 Rafael Contreras<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2000-2001<\/td>\n<td width=\"156\">BS. 2001<\/p>\n<p>U. of Colombia, SA<\/td>\n<td width=\"228\">Post-Doctoral<\/p>\n<p>US<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">14.\u00a0 Sylvia Berr\u00edos<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer-2001<\/td>\n<td width=\"156\">UPR-Humacao<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">15.\u00a0 Johanna M\u00e9ndez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer-2001<\/td>\n<td width=\"156\">UPR-Bayam\u00f3n<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">16.\u00a0 Miguel Arroyo<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">1996-2001<\/td>\n<td width=\"156\">Ph.D. 2001<\/td>\n<td width=\"228\">PhD Captain<\/p>\n<p>Walter Reed Army Research Institute<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">17.\u00a0 Manuel Santiago<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2000-2001<\/td>\n<td width=\"156\">BS<\/td>\n<td width=\"228\">MS-School of Public Health<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">18.\u00a0 Johanna D\u00edaz<\/td>\n<td width=\"138\">(G)<\/p>\n<p>&nbsp;<\/td>\n<td width=\"150\">Summer-2001<\/td>\n<td width=\"156\">UPR-MSC<\/td>\n<td width=\"228\">PhD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">19.\u00a0 Aksim G. Rivera<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2001<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">UG-UPR System<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">20.\u00a0 Lynnette L\u00f3pez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2001<\/td>\n<td width=\"156\">UPR-Bayam\u00f3n<\/td>\n<td width=\"228\">MD PhD student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">21.\u00a0 Lourdes Rodriguez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2004<\/td>\n<td width=\"156\">UPR-Humacao<\/td>\n<td width=\"228\">UG-UPR System<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">22.\u00a0 Edwin S\u00e1nchez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">1998-2003<\/td>\n<td width=\"156\">Ph.D. 2003<\/p>\n<p>UPR-MSC<\/td>\n<td width=\"228\">PhD Research Scientist<\/p>\n<p>Abbott Labs<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">23.\u00a0 Pedro V\u00e9lez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2001-2003<\/td>\n<td width=\"156\">UPR-MSC<\/td>\n<td width=\"228\">Master, MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">24.\u00a0 Dianedis Toro<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2001-2008<\/td>\n<td width=\"156\">Ph.D.UPR-MSC(RISE)<\/td>\n<td width=\"228\">PhD Faculty UPR Bayam\u00f3n<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">25.\u00a0 Claribel Luciano<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2003-2008<\/td>\n<td width=\"156\">Ph.D. UPR-MSC(RISE)<\/td>\n<td width=\"228\">PhD Faculty SJB<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">26.\u00a0 Ixane Velazquez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2005-2008<\/td>\n<td width=\"156\">MS UPR-MSC<\/td>\n<td width=\"228\">MS AMGEN<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">27.\u00a0 Juliana Perez Laspiur, PhD<\/td>\n<td width=\"138\">Postdoc<\/td>\n<td width=\"150\">2006-2015<\/td>\n<td width=\"156\">U of Michigan<\/td>\n<td width=\"228\">Faculty UPR Aguadilla<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">28.\u00a0 Lynette Bosques<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2006<\/td>\n<td width=\"156\">UPR-MSC<\/td>\n<td width=\"228\">MD-PhD-US- Yale U<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">29.\u00a0 Stephanie Dorta<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2006-2007<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">PhD Assistant Professor UPR-MSC<\/p>\n<p>Dept of Microbiology<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">30.\u00a0 Katia Garcia<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2003-2009<\/td>\n<td width=\"156\">PhD 2009 UPR-MSC(RISE)<\/td>\n<td width=\"228\">PhD USDA<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">31.\u00a0 Rafael Romeu<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2009-2010<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">32.\u00a0 Christian Avil\u00e9s<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2010-present<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">33.\u00a0 Maria del Carmen Lopez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2010-present<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">34.\u00a0 Eillen Rodriguez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2007-2011<\/td>\n<td width=\"156\">Ph.D. UPR-MSC(RISE)<\/td>\n<td width=\"228\">PhD Scientific Manager AMGEN<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">35.\u00a0 Silvia Kares<\/td>\n<td width=\"138\">Lawyer<\/td>\n<td width=\"150\">2010-2011<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">36.\u00a0 Viviana Melendez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2011<\/td>\n<td width=\"156\">UPR-Mayaguez<\/td>\n<td width=\"228\">Medical School- UCC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">37.\u00a0 Raymond Quiles<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2011-present<\/td>\n<td width=\"156\">Interamericana<\/td>\n<td width=\"228\">Graduate School US<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">38.\u00a0 Gisela Delgado<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2011-present<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD San Juan Bautista<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">39.\u00a0 Frances Zen\u00f3n<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2010-2014<\/td>\n<td width=\"156\">Ph.D. UPR-MSC(RISE)<\/td>\n<td width=\"228\">Ph.D. Faculty<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">40.\u00a0 Mariangeline Gonzalez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2013-2014<\/td>\n<td width=\"156\">UPR_Rio Piedras<\/td>\n<td width=\"228\">MD- Researcher at UPR-MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">41.\u00a0 Linda Rivera, PhD<\/td>\n<td width=\"138\">Postdoc<\/td>\n<td width=\"150\">2009-2014<\/td>\n<td width=\"156\">RCM<\/td>\n<td width=\"228\">Faculty, UAGM-Carolina<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">42.\u00a0 Israel Mendez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2013-2014<\/td>\n<td width=\"156\">UPR_Rio Piedras<\/td>\n<td width=\"228\">MD UPR-MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">43.\u00a0 Natalia Hernandez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2013-2014<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD UPR- MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">44.\u00a0 Frances Acevedo<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2013-2015<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Ph.D. U. of Michigan Graduate School<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">45.\u00a0 Karla Pag\u00e1n<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2014-2016<\/td>\n<td width=\"156\">UPR-Bayam\u00f3n<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">46.\u00a0 Alexandra Ogando<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2014-2016<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">47.\u00a0 Krystal Colon<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2009-2015<\/td>\n<td width=\"156\">Ph.D. UPR-MSC (RISE)<\/td>\n<td width=\"228\">Ph.D. Pfizer<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">48.\u00a0 Yisel Cantres<\/td>\n<td width=\"138\">(G)<\/p>\n<p>Post doc<\/td>\n<td width=\"150\">2010-2015<\/p>\n<p>2015-2017<\/td>\n<td width=\"156\">Ph.D. UPR-MSC (RISE)<\/td>\n<td width=\"228\">Postdoc, UPR-MSC, Assistant Professor Dept of Microbiology UPR-MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">49.\u00a0 Kristal M. Delgado Serrano<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2015<\/td>\n<td width=\"156\">UPR- Mayag\u00fcez<\/td>\n<td width=\"228\">Undergraduate Student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">50.\u00a0 Nicole Marz\u00e1n Rivera<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\"><\/td>\n<td width=\"156\">Ph.D. UPR-MSC<\/td>\n<td width=\"228\">Researcher at a Provete Industry<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">51.\u00a0 Eraysy Machin<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2016-2017<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">MD UPR-MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">52.\u00a0 Jos\u00e9 Sanchez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2017-2018<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Biol 4990 student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">53.\u00a0 Manuel Alvarez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2017-2018<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">PhD Bioinformatics<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">54.\u00a0 Aemil Santos<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2017-2018<\/td>\n<td width=\"156\">UPR-Bayamon<\/td>\n<td width=\"228\">Amgen<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">55.\u00a0 Camille Zen\u00f3n<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2014-2019<\/td>\n<td width=\"156\">MS UPR-MSC<\/td>\n<td width=\"228\">Research Technician, MSC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">56.\u00a0 Omar V\u00e9lez<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2014-2019<\/td>\n<td width=\"156\">PhD UPR-MSC(RISE)<\/td>\n<td width=\"228\">PhD Assistant Professor UPR-Ponce<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">57.\u00a0 Estheysy Roman Pagan<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2018-2019<\/td>\n<td width=\"156\">UNE<\/td>\n<td width=\"228\">Research\u00a0 student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">58.\u00a0 Adriadna Ramirez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2019-2020<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical School Student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">59.\u00a0 Jean Perez Vargas<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2019-2020<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical School Student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">60.\u00a0 Andrea Gonzalez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2019-2020<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Biol 4990<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">61.\u00a0 Julio Rosado-Philipi<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2019-2021<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical School Student and Volunteer<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">62.\u00a0 Lester Rosario<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2015-2021<\/td>\n<td width=\"156\">PhD UPR-MSC (RISE)<\/td>\n<td width=\"228\">NIH F99\/K00, ex-RISE, Doctoral student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">63.\u00a0 Luis Garcia Reque\u00f1a<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2019-2021<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical School Student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">64.\u00a0 Luz Cartagena<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2017-2021<\/td>\n<td width=\"156\">STEP-UP<\/p>\n<p>UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical School Student, Guadalajara<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">65.\u00a0 Juan C Fipo Cuadrado<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2018-2020<\/td>\n<td width=\"156\">UPR-Bayamon<\/td>\n<td width=\"228\">Medical School Student<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">66.\u00a0 Gabriel Borges<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">2015-2023<\/td>\n<td width=\"156\">PhD UPR-MSC (RISE)<\/td>\n<td width=\"228\">Postdoc CCC<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">67.\u00a0 Veronica Rivera Nieves<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2020-2023<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Maestria en Salud Publica<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">68.\u00a0 Alexandra Rosa<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2022-2024<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Medical Student Ponce Health Sciences<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">69.\u00a0 Alana Mera<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2024<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">STEP-UP<\/td>\n<\/tr>\n<tr>\n<td width=\"169\"><strong>Present students<\/strong><\/td>\n<td width=\"138\"><\/td>\n<td width=\"150\"><\/td>\n<td width=\"156\"><\/td>\n<td width=\"228\"><\/td>\n<\/tr>\n<tr>\n<td width=\"169\">Luisa Rodriguez<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">2022-present<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">Biol 4990<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">Jorlyann<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2025<\/td>\n<td width=\"156\">UPR-Cayey<\/td>\n<td width=\"228\">PR-INBRE STCE<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">Xandra Pena Diaz<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2025<\/td>\n<td width=\"156\">UPR-Cayey<\/td>\n<td width=\"228\">CBIOL 5990<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">Franco Roark<\/td>\n<td width=\"138\">(UG)<\/td>\n<td width=\"150\">Summer 2025<\/td>\n<td width=\"156\">Mason University<\/td>\n<td width=\"228\">CBIOL 5990<\/td>\n<\/tr>\n<tr>\n<td width=\"169\">Nicolas Miranda Diaz<\/td>\n<td width=\"138\">(G)<\/td>\n<td width=\"150\">Summer 2025<\/td>\n<td width=\"156\">UPR-Rio Piedras<\/td>\n<td width=\"228\">CBIOL 5990<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-258169ec8c6f1843b\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-258169ec8c6f1843b uvc-7871  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-258169ec8c6f1843b h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-258169ec8c6f1843b .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ol>\n<li><strong>Melendez-Guerrero LM<\/strong>, Nicholson JK, and MacDougal JS. 1990. In vitro infection of monocytes with HIVBa-L. Effect on cell surface expression of CD4, CD14, HLA-DR, and HLA-DQ. AIDS Res Hum Retroviruses. 1990 Jun;6(6):731-41.PMID:1694679<\/li>\n<li><strong>Melendez-Guerrero L<\/strong>, Nicholson J, and MacDougal S. 1991. In vitro infection of Human Monocytes with HIV-1<sub>Ba-L<\/sub>. Effect on Accessory Cell Function for T-Cell Proliferation In Vitro. AIDS Res and Human Retroviruses 7(5): 465-474. PMID: 1873081.<\/li>\n<li>Renta JY, Cadilla CL, Vega ME, Hillyer GV, Estrada C, Jim\u00e9nez E, Abreu E, M\u00e9ndez I, Gand\u00eda J, <strong>Mel\u00e9ndez-Guerrero LM<\/strong>. 1997. Longitudinal studies on maternal HIV-1 variants by biological phenotyping, sequence analysis and viral load. Cell Mol Biol 43(7):1097-114. PMID: 9449544<\/li>\n<li>Plaud-Valentin M, Delgado R, Garcia V, Zorrilla C, Gandia J, <strong>Mel\u00e9ndez-Guerrero LM.<\/strong> HIV infection of placental macrophages: effect on the secretion of HIV stimulatory cytokines. Cell Mol Biol (Noisy-le-grand). 1999 Jun;45(4):423-31. PMID: 10432189.<\/li>\n<li>Torres G, Garc\u00eda V, S\u00e1nchez E, Segarra A, Patterson BK, <strong>Mel\u00e9ndez-Guerrero LM.<\/strong>Expression of the HIV-1 co-receptors CCR5 and CXCR4 on placental macrophages and the effect of IL-10 on their expression. Placenta. Suppl A:S29-33. PMID: 11312625.<\/li>\n<li>Sanchez-Carrasquillo E, Garc\u00eda V, Rivera CE, Febo I, <strong>Melendez-Guerrero LM<\/strong>. 2000. CCR5 and beta-chemokines in HIV-1 infected children. P R Health Sci J. 19(4):345-51. PMID: 11300123<\/li>\n<li><strong>Melendez-Guerrero LM,<\/strong> Arroyo MA, Vega ME, Jimenez E, Hillyer GV, Cadilla CL.2001. Characterization of HIV isolates from Puerto Rican maternal-infant pairs reveal predominance of non-syncytium inducing (NSI) variants with CCR5 genotype. Cell Mol Biol (Noisy-le-grand). 47; 39-47. PMID: 11936872.<\/li>\n<li>Mel\u00e9ndez J, Garc\u00eda V, S\u00e1nchez E, Delgado R, Torres G, <strong>Mel\u00e9ndez-Guerrero LM<\/strong>. 2001. Is decreased HIV-1 infectivity of placental macrophages caused by high levels of beta-chemokines? Cell Mol Biol (Noisy-le-grand). 47 OL51-9. PMID:11936874<\/li>\n<li>Ruff MR, <strong>Melendez-Guerrero LM,<\/strong> Yang QE, Ho WZ, Mikovits JW, Pert CB, Ruscetti FA. 2001. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 2001 Oct;52(1):63-75. PMID:11530189<\/li>\n<\/ol>\n<p>&nbsp;<\/p>\n<ol start=\"10\">\n<li>Arroyo MA, Tien H, Pag\u00e1n M, Swanstrom R, Hillyer GV, Cadilla CL<strong>, Mel\u00e9ndez-Guerrero LM<\/strong>. 2002. Virologic risk factors for vertical transmission of HIV type 1 in Puerto Rico. AIDS Res Hum Retroviruses. 18(6):447-60. PMID: 11958688.<\/li>\n<li>Luo X, Carlson KA, Wojna V, Mayo R, Biskup TM, Stoner J, Anderson J, Gendelman HE, <strong>Mel\u00e9ndez LM.<\/strong> Macrophage proteomic fingerprinting predicts HIV-1-associated cognitive impairment. Neurology. 2003 Jun 24;60(12):1931-7. PMID:12821735.<\/li>\n<li>Wojna V, Carlson KA, Luo X, Mayo R, <strong>Mel\u00e9ndez LM,<\/strong> Kraiselburd E, Gendelman HE. 2004. Proteomic fingerprinting of human immunodeficiency virus type 1-associated dementia from patient monocyte-derived macrophages: A case study. J Neurovirol. 2004;10 Suppl 1:74-81. PMID:14982743.<\/li>\n<li>Kamara P, <strong>Melendez-Guerrero L,<\/strong> Arroyo M, Weiss H, Jolly P. 2005. Maternal plasma viral load and neutralizing\/enhancing antibodies in vertical transmission of HIV: a non-randomized prospective study. Virol J. 2:15. PMID:15730556.<\/li>\n<li>Wojna V, Skolasky RL, Hechavarr\u00eda R, Mayo R, Selnes O, McArthur JC, <strong>Mel\u00e9ndez LM,<\/strong> Maldonado E, Zorrilla CD, Garc\u00eda H, Kraiselburd E, Nath A. 2006. Prevalence of human immunodeficiency virus-associated cognitive impairment in a group of Hispanic women at risk for neurological impairment. J Neurovirol. 2006 Oct;12(5):356-64. PMID:17065128<\/li>\n<li>Wojna V, Skolasky RL, McArthur JC, Maldonado E, Hechavarria R, Mayo R, Selnes O, Ginebra T, de la Torre T, Garcia H, Kraiselburd E, <strong>Melendez-Guerrero LM<\/strong>, Zorrilla CD, Nath A. 2007. Spanish validation of the HIV dementia scale in women. AIDS Patient Care STDS. 2007 Dec;21(12):930-41. PMID:18154490.<\/li>\n<li>Nieves DM, Plaud M, Wojna V, Skolasky R, <strong>Mel\u00e9ndez LM.<\/strong> Characterization of peripheral blood human immunodeficiency virus isolates from Hispanic women with cognitive impairment. J Neurovirol. 2007 Aug;13(4):315-27. PMID: 17849315.<\/li>\n<li>Rozek W, Ricardo-Dukelow M, Holloway S, Gendelman HE, Wojna V, <strong>Melendez LM,<\/strong> Ciborowski P. 2007. Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment. J Proteome Res. 2007 Nov;6(11):4189-99. Epub 2007 Oct 12. PMID: 17929958.<\/li>\n<li>Wojna V, Robles L, Skolasky RL, Mayo R, Selnes O, de la Torre T, Maldonado E, Nath A, <strong>Mel\u00e9ndez LM,<\/strong> Lasalde-Dominicci J. 2007. Associations of cigarette smoking with viral immune and cognitive function in human immunodeficiency virus-seropositive women. J Neurovirol. 2007 Dec;13(6):561-8. PMID:18097887.<\/li>\n<li>Laspiur JP, Anderson ER, Ciborowski P, Wojna V, Rozek W, Duan F, Mayo R, Rodr\u00edguez E, Plaud-Valent\u00edn M, Rodr\u00edguez-Orengo J, Gendelman HE, <strong>Mel\u00e9ndez LM.<\/strong> CSF proteomic fingerprints for HIV-associated cognitive impairment. J Neuroimmunol. 2007 Dec;192(1-2):157-70. Epub 2007 Oct 22. Erratum in: J Neuroimmunol. 2008 Dec 15;205(1-2):161. PMID:17950469.<\/li>\n<li>Luciano-Montalvo C, Ciborowski P, Duan F, Gendelman HE, <strong>Mel\u00e9ndez LM.<\/strong> Proteomic analyses associate cystatin B with restricted HIV-1 replication in placental macrophages. Placenta. 2008 Dec;29(12):1016-23. PMID: 18951626<\/li>\n<li>Luciano-Montalvo C, <strong>Mel\u00e9ndez LM.<\/strong> Cystatin B associates with signal transducer and activator of transcription 1 in monocyte-derived and placental macrophages. Placenta. 2009 May;30(5):464-7. PMID: 19342095.<\/li>\n<li>Garc\u00eda K, Garc\u00eda V, P\u00e9rez Laspiur J, Duan F, <strong>Mel\u00e9ndez LM.<\/strong> Characterization of the placental macrophage secretome: implications for antiviral activity. Placenta. 2009 Feb;30(2):149-55. PMID: 19070362<\/li>\n<li>Garc\u00eda-Crespo K, Cadilla C, Skolasky R, <strong>Mel\u00e9ndez LM.<\/strong> Restricted HIV-1 replication in placental macrophages is caused by inefficient viral transcription. J Leukoc Biol. 2010 Apr;87(4):633-6. PMID: 20042472.<\/li>\n<li>Toro-Nieves D (mentee, LM), Perez Laspiur J, Ciborowski P, Duan F, Wojna V, <strong>Mel\u00e9ndez LM<\/strong>. 2009. Proteomic analysis of HIV-1 infected monocyte-derived macrophage following infection with primary viral strains isolated from Hispanic women with cognitive impairment\u201d. <em>J NeuroVirology 1:36-50.<\/em><\/li>\n<li><em>Vel\u00e1zquez I <\/em>(Mentee, LM)<em>, Plaud M, P\u00e9rez-Laspiur J, Skolasky R, Wojna V and <strong>Mel\u00e9ndez LM<\/strong>. 2009. <\/em>Antioxidant enzyme dysfunction in monocytes and CSF of Hispanic women with HIV-associated cognitive impairment. <em>J Neuroimmunol<\/em> <em>209:206-211<\/em><\/li>\n<li><em>Garc\u00eda, K <\/em>(Mentee, LM)<em>, Garc\u00eda, V, Duan, F, Perez Laspiur J<strong>, Mel\u00e9ndez, L.M<\/strong>. 2009. <\/em>Characterization of the placental macrophage secretome: Implications for antiviral activity. <em> 30: 149-155.<\/em> PMID: 19070362<\/li>\n<li>Kraft-Terry S, Gerena Y, Wojna V, Plaud-Valentin M, Rodriguez Y, Ciborowski P, Mayo R, Skolasky R, Gendelman HE, <strong>Melendez LM.<\/strong> Proteomics analysis of monocytes from Hispanic women with HIV-associated dementia show depressed antioxidants. J. Proteomics and Clinical Applications 4:710-714. PMID:21137088<\/li>\n<li>Peters J, Dieppa-Perea L, <strong>Melendez LM*,<\/strong> Quirk GJ. 2010. Induction of fear extinction with hippocampus infralimbic BDNF.<u> Science <\/u>238:1288-1290. PMID: 20522777.<\/li>\n<li><strong>Melendez LM*,<\/strong> Colon K, Rivera L Rodriguez-Franco E, and Toro-Nieves D. (Invited Review) 2011. Proteomic analysis of HIV-infected macrophages. J Neuroimmune Pharmacol. 6:89-106. PMID: 21153888.<\/li>\n<li>Rivera-Rivera L, Perez-Laspiur J, Colon, K, and <strong>Melendez, LM*.<\/strong> Inhibition of interferon response by cystatin B: Implication in HIV replication of macrophage reservoirs. J Neurovirology 18:20-9. PMID: 22147503.<\/li>\n<li>Rodriguez E, Cantres Y, Plaud M, Romeu R, Rodriguez Y, Skolasky R, Melendez V, Cadilla C, and <strong>Melendez LM<\/strong>*. 2012. Dysregulation of macrophage-secreted cathepsin B contributes to HIV-1-linked neuronal apoptosi PLoS ONE 7(5): PMID: 22693552.<\/li>\n<li>Cantres-Rosario Y, Plaud-Valentin M, Gerena Y, Skolasky R, Wojna V, <strong>Mel\u00e9ndez LM*.<\/strong> Dysregulation of cathepsin B and its inhibitor cystatin B in monocytes and CSF from women with HIV-associated neurocognitive impairment. AIDS 27:347-356. PMID: 23291538.<\/li>\n<li>Rivera LE, Colon K, Cantres YM, Zenon FM, and <strong>Melendez, LM.<\/strong> Macrophage derived cystatin B\/cathepsin B in HIV replication and neuropathogenesis. Current HIV Research 12: 111-120. PMID:24862331.<\/li>\n<li>Agsalda-Garcia M, Shiramizu B, <strong>Melendez LM*,<\/strong> Plaud M, Liang C-Y, Wojna V. Different levels of HIV DNA copy numbers in cerebrospinal fluid cellular subsets. Journal of Health Care for the Poor and Underserved, 24(4) Suppl 8-16 doi: 10.1353\/hpu.2014.0010. PMID: 24241256; PMCID: PMC3844931.<\/li>\n<li>Zenon F, Segarra A, Gonzalez M, and <strong>Mel\u00e9ndez LM*,<\/strong> Cocaine Potentiates Cathepsin B Secretion and Neuronal Apoptosis from in HIV-infected Macrophages. J Neuroimmune Pharmacology. Published on line ahead of time DOI 10.1007\/s11481-014-9563-z<\/li>\n<li>V\u00e1zquez-Santiago F, Garc\u00eda Y, Rivera-Rom\u00e1n I, Noel RJ Jr, Wojna V, <strong>Mel\u00e9ndez LM,<\/strong> Rivera-Amill V. <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26167513\">Longitudinal Analysis of Cerebrospinal Fluid and Plasma <strong>HIV<\/strong>-1 Envelope Sequences Isolated From a Single Donor with <strong>HIV<\/strong> Asymptomatic Neurocognitive Impairment.<\/a> J Virol Antivir Res. 2015;4(1). doi: 10.4172\/2324-8955.1000135. PMID: 26167513. July, 2015<\/li>\n<li>Zen\u00f3n F, Cantres-Rosario Y, Adiga R, Gonzalez M, Rodriguez-Franco E, Langford D, <strong>Melendez LM. <\/strong><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26092112\">HIV-infected microglia mediate cathepsin B-induced neurotoxicity.<\/a> J Neurovirol. 2015 Jun 20. [Epub ahead of print] PMID: 26092112.<\/li>\n<li>Zen\u00f3n F, Jorge I, Cruz A, Suarez E, Segarra AC, V\u00e1zquez J, <strong>Mel\u00e9ndez LM<\/strong>, Serrano H. O18 proteomics reveal increased Human Apolipoprotein CIII in Hispanic HIV-1 positive women with HAART that use cocaine. Proteomics Clin Appl. 2015 Aug 10. doi: 10.1002\/prca.201400204. [Epub ahead of print] PMID: 26255783.<\/li>\n<li>Colon K, Perez-Laspiur J, Quiles R, Rodriguez Y, Wojna V, Shaffer SA, Leszyk J, Skolasky RL Jr, <strong>Melendez LM.<\/strong> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26220577\">Macrophage secretome from women with <strong>HIV<\/strong>-associated neurocognitive disorders.<\/a> Proteomics Clin Appl. 2015 Jul 29. doi: 10.1002\/prca.201400203. [Epub ahead of print PMID: 26220577.<\/li>\n<li>Colon K, V\u00e1zquez-Santiago F Rivera-Amill V, Delgado G, Massey SE, Wojna V, Noel RJ Jr6 and <strong>Mel\u00e9ndez LM<\/strong>. 2015. HIV Gp120 Sequence Variability Associated with HAND in Hispanic Women. J Virology and Antiviral Research. doi: 10.4172\/2324-8955.1000135. Epub 2015 Oct 6.<\/li>\n<li>Cantres-Rosario YM, Hernandez N, Negron K, Perez-Laspiur J, Leszyk J, Shaffer SA, <strong>Melendez LM.<\/strong> <a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26208400\">Interacting partners of macrophage-secreted cathepsin B contribute to <strong>HIV<\/strong>-induced neuronal apoptosis.<\/a> 2015 Jul 23. [Epub ahead of print] PMID: 26208400.<\/li>\n<li>Delgado-Velez M, Baez-Pagan C, Gerena Y, Quesada O, Santiago-Perez L, Capo-Velez C, Wojna V, <strong>Melendez L<\/strong>, Leon-Rivera R, Silva W, and Lasalde-Dominicci JA. The a-7nicotinic receptor is upregulated in immune cells from HIVseropositive women: Consequences to the cholinergic anti-inflammatory response. Clin and Translational Immunology 4, e53. Dec, 2015<\/li>\n<li>Rivera LE, Kraiselburd E, <strong>Mel\u00e9ndez LM<\/strong>. Cystatin B and HIV regulate the STAT-1 signaling circuit in HIV-infected and INF-\u03b2-treated human macrophages. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27137788\">J Neurovirol.<\/a> 2016 Oct;22(5):666-673. PMID:<\/li>\n<li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27137788\">27137788<\/a>. Epub 2016 May 2.<\/li>\n<li>Cantres-Rosario YM, Acevedo-Mariani FM, P\u00e9rez-Laspiur J, Haskins WE, Plaud M, Cantres-Rosario YM, Skolasky R, M\u00e9ndez-Berm\u00fadez I, Wojna V, <strong>Mel\u00e9ndez LM<\/strong>. Microwave &amp; magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment. <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28746408\">PLoS One.<\/a> 2017 Jul 26;12(7):e0181779. doi: 10.1371\/journal.pone.0181779. eCollection 2017.<\/li>\n<li>Mart\u00ednez-Rivera FJ, P\u00e9rez-Laspiur J, Santiago-Gascot ME, Alem\u00e1n-Reyes AG, Garc\u00eda-Santiago E, Rodr\u00edguez-P\u00e9rez Y, Calo-Guadalupe C, Otero-Pag\u00e1n I, Ayala-Pag\u00e1n RN, Mart\u00ednez M, Cantres-Rosario YM, <strong>Mel\u00e9ndez LM<\/strong>, Barreto-Estrada JL. 2017. Differential protein expression profile in the hypothalamic GT1-7 cell line after exposure to anabolic androgenic steroids. PLoS ONE Jul 18;12(7): e0180409. PMID: 28719635.<\/li>\n<li>Rosario-Rodriguez LJ, Col\u00f3n K, Borges-V\u00e9lez G, Negr\u00f3n K,<strong>Mel\u00e9ndez LM.<\/strong> Dimethyl fumarate prevents HIV-induced lysosomal dysfunction and cathepsin B release from macrophages. J Neuroimmune Pharmacol. 2018 Jul 9. doi: 10.1007\/s11481-018-9794-5. [Epub ahead of print] PMID:29987592.<\/li>\n<li>Rosas-Vidal L, Lozada V, Cantres-Rosario Y, Vega-Medina A, <strong>Melendez L<\/strong>, and Quirk G. 2018. Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. Neuropsychopharmacology. Manuscript #NPP-17-1265RR<\/li>\n<li>L\u00f3pez, O. V., Gorantla, S., Segarra, A. C., Norat, M. C. A., \u00c1lvarez, M., Skolasky, R. L., &amp; <strong>Mel\u00e9ndez, L.<\/strong> 2019. \u201cSigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine\u201d. <em>Journal of Neuroimmune Pharmacology<\/em>, 1-15.<\/li>\n<li>Cantres-Rosario, YM. Santos A, Ortiz-Rodriguez S., Santos A, Plaud M, Negron K, Cotto B, Langford D, and <strong>Melendez LM.<\/strong> HIV-infected macrophages induce extracellular cathepsin B uptake and damage to neurons. Nature Sci Rep. May 29;9(1):8006. doi: 10.1038\/s41598-019-44463-1.<\/li>\n<li>Schmoker AM, Perez Pearson LM, Cruz C, Colon Flores LG, Branfeild S, Pag\u00e1n Torres FD, Fonseca K, Cantres YM, Salgado Ramirez CA,<strong>Melendez LM<\/strong>, Ballif BA, Washington AV. 2020. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/31923473\/?from_term=Melendez+LM&amp;from_pos=7\">Defining the TLT-1 interactome from resting and activated human platelets.<\/a> J Proteomics. 2020 Mar 20;215:103638. doi: 10.1016\/j.jprot.2020.103638. Epub 2020 Jan 8.PMID:\u00a031923473<\/li>\n<li>Borges-Velez G, Rosario-Rodriguez L, Rosado-Philippi JE, Cartagena LJ, Garcia-Requena L, Gonzalez A, Perez J, and <strong>Melendez <\/strong> 2020. SARS-CoV-2:Biology,Detection, Macrophage Mediated Pathogenesis and Potential Treatments. Virol Immunol J. 2020;4(2):242. doi: 10.23880\/vij-16000242. Epub 2020 Jul 2.PMID:\u00a034485853<\/li>\n<li>Mart\u00ednez\u2013Mat\u00edas N, Chorna N, Gonz\u00e1lez\u2013Crespo S, Villanueva L, Montes\u2013Rodr\u00edguea I, <strong>Melendez-Aponte LM<\/strong>, Roche\u2013Lima A, Carrasquillo\u2013Carri\u00f3n K, Santiago-Cartagena E, Rymond BC, Babu M, Stagljar I, and Rodr\u00edguez\u2013Medina JR. 2021. Toward the discovery of biological functions associated with the mechanosensor Mtl1p of <em>Saccharomyces cerevisiae<\/em>via integrative multi-OMICs analysis. <em>Scientific Reports<\/em> Apr 1;11(1):7411.<em> DOI: 10.1038\/s41598-021-86671-8.\u00a0<\/em>PMID:\u00a0<strong>33795741<\/strong> PMCID:\u00a0<a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/pmc8016984\/\">PMC8016984<\/a><\/li>\n<li>Borges-V\u00e9lez G, Rosado-Philippi J, Cantres-Rosario YM, Carrasquillo-Carrion K, Roche-Lima A, P\u00e9rez-Vargas J, Gonz\u00e1lez-Mart\u00ednez A, Correa-Rivas MS, and <strong>Mel\u00e9nde<\/strong><strong>z LM<\/strong>. Zika virus infection of the placenta alters extracellular matrix proteome. J Mol Histol. doi: 10.1007\/s10735-021-09994-w. Online ahead of print.PMID:\u00a034264436<\/li>\n<li>Zenon-Melendez CN, Carrasquillo Carri\u00f3n K, Cantres Rosario Y, Roman E, Roche Lima A, &amp; <strong><u>Mel\u00e9ndez LM.<\/u><\/strong> Inhibition of cathepsin B and SAPC secreted by HIV-infected macrophages reverse common and unique apoptosis pathways. J of Proteome Research January 7<em>.<\/em> <a href=\"https:\/\/doi.org\/10.1021\/acs.jproteome.1c00187\">https:\/\/doi.org\/10.1021\/acs.jproteome.1c00187<\/a><\/li>\n<li>Rosario-Rodriguez LJ, Gerena Y, Cuadrado JC, Cartagena LJ, and <strong>Mel\u00e9ndez LM. <\/strong> Cannabinoid receptor type 2 agonist JWH-133 decreases cathepsin B secretion and neurotoxicity from HIV-infected macrophages. 2022. Nature Sci. Rep. Jan 7;12 (1):233. PMID:\u00a034996989<\/li>\n<li>Bidlack JM, Chang SL, Fitting S, Gendelman HE, Gorantla S, Kumar S, Garibaldi Marcondes MC, Meigs DD, <strong>Mel\u00e9ndez LM<\/strong>, Sariyer IK, Yelamanchili S. 2022. The COVID-19 Pandemic: Reflections of Science, Person, and Challenge in Academic Research Settings. J Neuroimmune Pharmacology <a href=\"https:\/\/doi.org\/10.1007\/s11481-021-10035-2\">https:\/\/doi.org\/10.1007\/s11481-021-10035-2<\/a><\/li>\n<li>Borges-V\u00e9lez G, Arroyo JA, Cantres-Rosario YM, Rodriguez de Jesus A, Roche-Lima A, Rosario-Rodriguez L, Correa-Rivas MS, Campos-Rivera M, Rosado-Philippi J, and <strong>Mel\u00e9ndez LM. 2022.<\/strong> Decreased CSTB, RAGE and Axl receptor is associated with Zika infection in the human placenta. <em>Cells<\/em> <em>11<\/em>, 3627. <a href=\"https:\/\/doi.org\/10.3390\/cells11223627\">https:\/\/doi.org\/10.3390\/cells11223627<\/a><\/li>\n<li>Bayr\u00f3n-Marrero Z, Branfield S, Men\u00e9ndez-P\u00e9rez J, Nieves-L\u00f3pez B, Ospina C, Cantres-Rosario Y, <strong>Melendez LM,<\/strong> Robert Hunter R, Gibson A, Maldonado-Mart\u00ednez G, and Washington AV. The Characterization of Soluble Triggering Receptor Expressed on Myeloid Cells Like-Transcript-1 (sTLT-1) fragment as a biomarker for Stable Cardiovascular Diseases. 2023. Research and Practice in Thrombosis and Haemostasis. <em> J. Mol. Sci.<\/em><em>24<\/em>(17), 13632;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/ijms241713632\">https:\/\/doi.org\/10.3390\/ijms241713632<\/a><\/li>\n<li>Rosario-Rodriguez LJ, Cantres-Rosario YM, Carrasquillo-Carrion K, Rodriguez de Jesus A, Garcia-Reque\u00f1a L, Roche-Lima A, and <strong>Mel\u00e9ndez <\/strong><strong>2024. <\/strong>Quantitative proteomics reveal that CB2R agonist JWH-133 Downregulates NF-kappaB activation, oxidative stress, and lysosomal exocytosis from HIV infected macrophages. Int J Mol Sci. 13;25(6):3246. doi: 10.3390\/ijms25063246.PMID:\u00a038542221.<\/li>\n<li>Rosario-Rodr\u00edguez LJ, Cantres-Rosario YM, Rodr\u00edguez-De Jes\u00fas AE, Carrasquillo-Carri\u00f3n K, M\u00e9ndez LB, Rivera-Nieves V , Rosa-Diaz A, Roche Lima A, Bertran J, <strong>Mel\u00e9ndez, LM.<\/strong> Plasma proteins associated with COVID-19 severity in Puerto Rico. Int J Mol Sci.<em>25<\/em>(10), 5426;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/ijms25105426\">https:\/\/doi.org\/10.3390\/ijms25105426<\/a><\/li>\n<li>V\u00e9lez-L\u00f3pez O, Carrasquillo-Carri\u00f3n K, Yadira M. Cantres-Rosario, Mach\u00edn-Mart\u00ednez E, \u00c1lvarez-Rios ME, Roche-Lima A, Tosado-Rodr\u00edguez EL, <strong>Mel\u00e9ndez LM.<\/strong> Analysis of Sigma\u20101 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV\u20101\u2010Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics. Biomedicines <em>12<\/em>,1934. https:\/\/doi.org\/ 10.3390\/biomedicines12091934<\/li>\n<li>Rivera-Serrano, M; Flores-Col\u00f3n, M; Valiyeva, F; <strong>Mel\u00e9ndez, LM<\/strong>; Vivas-Mejia, P. 2025. Upregulation of MMP3 promotes cisplatin resistance in ovarian cancer. <em> J. Mol. Sci.<\/em> <em>26<\/em>(9), 4012;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/ijms26094012\">https:\/\/doi.org\/10.3390\/ijms26094012<\/a><\/li>\n<li>Morales-Caba\u0301n BM, Cantres-Rosario YM, Tosado-Rodri\u0301guez EL, Roche-Lima A, Mele\u0301ndez LM, Boukli NM, and Suarez-Arroyo IJ. SCAMP3-Driven Regulation of ERK1\/2 and Autophagy Phosphoproteomics Signatures in Triple-Negative Breast Cancer. Submitted to Cells. May 25, 2025.<\/li>\n<li>Armina-Rodriguez, Valdez BN, Ocasio-Malav\u00e9 C, Cantres-Rosario YM, Carrasquillo Carri\u00f3n K, Mel\u00e9ndez LM, Roche-Lima A, Tosado E, Espino AM. Quantitative Proteomics Reveals Fh15 as an Antagonist of TLR4 Downregulating the Activation of NF-\u03baB, Inducible Nitric Oxide, Phagosome Signaling Pathways, and Oxidative Stress of LPS-stimulated Macrophages. <em> J. Mol. Sci.<\/em><strong>2025<\/strong>,\u00a0<em>26<\/em>(14), 6914;\u00a0<a href=\"https:\/\/doi.org\/10.3390\/ijms26146914\"><strong>https:\/\/doi.org\/10.3390\/ijms26146914<\/strong><\/a><\/li>\n<\/ol>\n<p><strong>BOOK CHAPTERS \/ TECHNICAL REPORTS<\/strong><\/p>\n<ul>\n<li>Gendelman, H, Anderson E, Melendez, L, and Zheng, J. Chemokines and their receptors in HIV-1 neuropathogenesis. 2006. <em>In Vivo Models of HIV Disease and Control. Eds H. Friedman, S. Specter, and<\/em> <em>M. Bendinelli. Springer. p. 45-80.<\/em><\/li>\n<li>Melendez, L.M., Luciano, C. Mayo-Santana R., Wojna, V. Ethnicity and Neuro-AIDS Conditions in the HAART Era. 2009. In &#8220;The Spectrum of NeuroAIDS Disorders: Pathophysiology, Diagnosis, and Treatment&#8221;. ASM Press. p. 427-441.<\/li>\n<\/ul>\n<p><strong>SELECTED HONORS\/AWARDS<\/strong><\/p>\n<ol>\n<li>Fellowship from the government of Puerto Rico (Fomento Industrial) for studies leading to M.S in Industrial Microbiology, 1979-81.<\/li>\n<li>Minority Access Research Career faculty fellowship from NIH for doctoral studies, 1985-89.<\/li>\n<li>Co-investigator in an NIH funded R0-1 to study the mechanisms of transplacental transmission of HIV, 1991-92.<\/li>\n<li>Principal investigator in a two-year project entitled: &#8220;Role of the placenta in HIV-1 vertical transmission&#8221;, 1993-95.\u00a0 Sponsored by the Deanship of Academic Affair &#8220;CIDIC&#8221;.<\/li>\n<li>Activity coordinator in a NIH-RCMI funded research grant entitled: &#8220;HIV-1 Env Gene variation and tropism in vertical transmission, RR-03051, 1994-98.<\/li>\n<li>Travel Award from NIH to Keystone symposia entitled: &#8220;NIH-AIDS Postdoctoral Fellows meeting&#8221;.\u00a0 Albuquerque, New M\u00e9xico, 1993.<\/li>\n<li>Travel Award from NIH-RCMI to First National HIV Meeting in Washington, D.C., 1993.<\/li>\n<li>Principal Investigator in a NIH-MBRS funded grant entitled: &#8220;Role of the placenta in vertical transmission of HIV&#8221;.\u00a0 SO6 GM08224.<\/li>\n<li>Award from the Dean of Biomedical Sciences and the Program of High School Teachers and Students (K-12 Program, 1995) for advising students in research projects during the summer. Sponsored by NIH Grant #R25 RR 10852.<\/li>\n<li>Professional &#8211; Excellence Award from the Dean of Allied Health School. 1996.<\/li>\n<li>Travel Award for FASEB, Summer Research Conference on &#8220;Virus Assembly&#8221; Vermont, 1998.<\/li>\n<li>Glaxo-Welcome Research Award in the Category of Researcher with Experience.1999.<\/li>\n<li>Principal Investigator in NIH-SCORE Program funded research grant entitled:\u00a0 &#8220;Role of Chemokine Receptors in HIV-1 infection across the placenta&#8221;.\u00a0 2000-2004. SO6GM08224.<\/li>\n<li>Principal Investigator in NIH-SCORE Program funded research grant entitled:\u00a0 &#8221; Protein profiling of \u201cputative\u201d anti-retroviral factors in placental macrophages\u201d. 2004-2008. S06GM008224.<\/li>\n<li>Principal Investigator in NIH-Specialized Neuroscience Research Program (SNRP) funded research grant entitled:\u00a0 &#8221; Monocyte Immunity and HIV Dementia\u201d. 2001-2008<\/li>\n<li>Coordinator in the NIH-RCMI G12RR03051 activity entitled: \u201cClinical Proteomics Discovery Core Facility\u201d-2006-2011.<\/li>\n<li>Elected Academic Senator from the School of Medicine 2008-2010.<\/li>\n<li>Principal Investigator in the NIH-RO1 entitled 1R01MH083516 &#8211; 01 \u00a0 Modulation of Cystatins and Cathepsins in HIV-1 Neuropathogenesis. 2009-2012.<\/li>\n<li>Honorary Mention for \u201cMonocyte Immunity and HIV Dementia\u201d. Merck Innovation Awards. 2009.<\/li>\n<li>NIH reviewer of a special emphasis panels. \u201cMechanisms of Drug Abuse Interactions with HIV Neuropathogenesis\u201d and \u201cAlcohol abuse Conference R13\/U13 Grants\u201d (2007-2009).\n<ol>\n<li>Martin Delaney R01 proposals on HIV Reservoirs; HIV and Aging (2011-2012).<\/li>\n<li>NIMH P01 Novel NeuroAIDS Therapeutics: Integrated Preclinical\/Clinical Program (March 2014).<\/li>\n<\/ol>\n<\/li>\n<li>Key Proteomics Director in the NIMHHD 8G12-MD007600 activity entitled: \u201cTranslational Proteomics Center. 2006-2016.<\/li>\n<li>Invitations to present research at RCMI meeting 2012 and Temple University Oct 2012.<\/li>\n<li>HiREC Advisory Committee (2013-present)<\/li>\n<li>Research Advisory Committee to the Chancellor (2010-2014)<\/li>\n<li>Search Committee for a new Dean of the School of Medicine (August- October 2014).<\/li>\n<li>Principal Investigator in NIH-NIGMS SC1 \u201cTargeting Macrophage derived cathepsin 1 in HIV neurocognitive disorders\u201d May 2015-January 2019.<\/li>\n<li>Invitation for an oral presentation. 2<sup>nd<\/sup> International Conference on Retroviruses and Novel Drugs. South Africa, June 30, 2016.<\/li>\n<li>Elected Council of the Society for Neuroimmune Pharmacology- April 2017-2022<\/li>\n<li>RISE Program Progress Report Reviewer May 2014-present<\/li>\n<li>INBRE Program Pilot Proposal Reviewer May 2016-present<\/li>\n<li>INBRE Proteomics Core Facility Coordinator 2016-present<\/li>\n<li>Elected Academic Senator from the School of Medicine 2017-2019.<\/li>\n<li>Elected President of Senate Academic Affairs Committee 2017-2018.<\/li>\n<li>1<sup>st<\/sup> HiREC Award on Excellence in Clinical and Translational Research. May 2019<\/li>\n<li>Invited Reviewer for NIH grants on US and Brazil collaboration. July 2019.<\/li>\n<li>Puerto Rico Society of Microbiologist 63rd Annual Meeting; Premio Arturo Carri\u00f3n, June 4, 2021<\/li>\n<li>Puerto Rico Health Sciences Journal Associate Editor, August 2021<\/li>\n<li>Abstract Reviewer Medical Sciences Campus Scientific Research Forum March 2022<\/li>\n<li>Research Abstract Committee member of the Hispanic Alliance of Clinical and Translational Research Scientific Day March 2022.<\/li>\n<li>Invited Speaker for 14<sup>th<\/sup> UPR RISE Area Conference &#8220;Two Years of COVID-19: Lessons and Improvements&#8221;.\u00a0 Embassy Suites Hotel, San Juan, PR. April 9, 2022.<\/li>\n<li>Hispanic Alliance Researcher Productivity Award. Hispanic Alliance of Clinical and Translational Research Scientific Day. Hotel Royal Sonesta, San Juan, PR. May 4, 2022.<\/li>\n<li>Invited reviewer for PlosONE, December 2022<\/li>\n<li>Travel award for the IDeA Proteomics Symposia for Core Directors and Staff. Feb 7-10, 2023<\/li>\n<li>Puerto Rico IDeA Network of Biomedical Research Excellence Pilot proposal reviewer, January 2023<\/li>\n<li>Invited by the Society on NeuroImmune Pharmacology (SNIP) to co-chair Symposium 6 on March 18, 2023, in the 27th SNIP Annual Conference to be held in New Delhi, India from 15th to 18th in March 2023.<\/li>\n<li>RCMI National meeting Abstract Reviewer. April 2023<\/li>\n<li>Invited reviewer for manuscript J of Neuroimmune Pharmacology and Therapeutics. April 2023<\/li>\n<li>Invited reviewer for J of Cellular and Molecular Histology. April 2023<\/li>\n<li>Invited Speaker for University of Vermont Department of Biology. May 1, 2023<\/li>\n<li>NIH Reviewer F31 and F32 HIV training grants ZRG1F17A-J(20) on July, 2023<\/li>\n<li>Nominated for the Sigma Xi Society membership. August 29, 2023<\/li>\n<li>Invited reviewer for Nature Communications, December 2023<\/li>\n<li>NIH Invited reviewer for the HIV Comorbidities and Clinical Studies (HCCS) study section July 9-10, 2024.<\/li>\n<li>Awarded NIH-Step-Up mentoring undergraduate student Ms. Alana Mera. June and July 2024<\/li>\n<li>Invited Reviewer to Journal Aging-June 27, 2024<\/li>\n<li>Invited Reviewer for AIDS journal-July 25, 2024<\/li>\n<li>External Faculty Evaluator, Dept. of Tropical Medicine, Medical Microbiology, and Pharmacology, U. of Manoa, Hawaii-July, 2024<\/li>\n<li>Invited Reviewer for Journal of Neuroimmune Pharmacology- September 1, 2024<\/li>\n<li>Invited Reviewer for MDPI-Proteomes- June 2025<\/li>\n<\/ol>\n<p><strong>Patents Submitted:<\/strong><\/p>\n<ol>\n<li>A method to reduce HIV replication in macrophages.<\/li>\n<li>Proteins associated with HIV induced dementia in monocytes and CSF.<\/li>\n<\/ol>\n<p><strong>Patents Awarded:<\/strong><\/p>\n<ol>\n<li>A method of reducing HIV-Replication on human body tissue comprising down regulating the expression of the protein Cystatin B on said human body tissue Pat No. 8,143,231. Awarded to Drs. Melendez and Claribel Luciano. 2012.<\/li>\n<\/ol>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1984,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-810","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team\/810","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=810"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/1984"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=810"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team_category?post=810"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}