{"id":813,"date":"2016-03-10T13:42:50","date_gmt":"2016-03-10T17:42:50","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/micro\/?post_type=dt_team&#038;p=813"},"modified":"2024-09-05T07:51:56","modified_gmt":"2024-09-05T11:51:56","slug":"dr-adelfa-e-serrano","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-adelfa-e-serrano\/","title":{"rendered":"Dr. Adelfa E. Serrano"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-968769d2d9e159d44\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-968769d2d9e159d44 uvc-41 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-968769d2d9e159d44 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Adelfa E. Serrano<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-968769d2d9e159d44 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-a629d965ed6e956668a0a64885609100.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-a629d965ed6e956668a0a64885609100.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-a629d965ed6e956668a0a64885609100 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-a629d965ed6e956668a0a64885609100 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-a629d965ed6e956668a0a64885609100 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/dra-adelfa-serrano.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2016\/03\/dra-adelfa-serrano.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/micro\/dt_team\/dr-adelfa-e-serrano\/dra-adelfa-serrano\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Adelfa E. Serrano Brizuela\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-7654\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-7654 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:adelfa.serrano@upr.edu\">adelfa.serrano@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-7683\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-7683 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Laboratory of Molecular and Cellular Biology of Parasites: Malaria<\/span><br \/>\n<span style=\"color: #ffffff;\">Rm A-310, Rm A-346, Rm A-349<\/span><br \/>\n<span style=\"color: #ffffff;\">Department of Microbiology and Medical Zoology,<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto-Rico-School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067,<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, P.R. 00936-5067.<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-7453\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-7453 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><strong>Phone Office: <\/strong><\/span><br \/>\n<span style=\"color: #ffffff;\">787) 758-2525 ext.: X-1313; <\/span><br \/>\n<span style=\"color: #ffffff;\">(787) 751-9486<\/span><br \/>\n<span style=\"color: #ffffff;\"><strong>Phone Lab: <\/strong><\/span><br \/>\n<span style=\"color: #ffffff;\">(787) 758-2525, X-2217, X-1314<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S. Biology , University of Puerto Rico, R.P., P.R. 1979<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. Biology\/Parasite Immunology, University of Puerto Rico, R.P., P.R. 1981<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph. D. Zoo\/Immunoparasitology, University of Georgia, Dept. of Zoology 1987<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Post-doc Molec. Biol. of Parasites, Harvard School of Public Health, Trop.Pub. Health 1991<\/span><\/li>\n<\/ul>\n<\/div>[vc_column_text css=&#8221;&#8221;]<span style=\"color: #ffffff;\">Coordinator AIDS and Infectious Diseases Laboratory (Rm A-349), RCMI-Center for Molecular Genetics and Infectious Diseases Research (Serrano, Activity Coordinator)<\/span>[\/vc_column_text]\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-767369d2d9e15b056\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-767369d2d9e15b056 uvc-8930  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-767369d2d9e15b056 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">ACADEMIC PROFILES<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-767369d2d9e15b056 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>ORCID<\/strong>: https:\/\/orcid.org\/0000-0001-5929-9973\u00a0\u00a0\u00a0<a href=\"https:\/\/www.cienciapr.org\/en\/user\/aserrano\">https:\/\/www.cienciapr.org\/en\/user\/aserrano<\/a><br \/>\n<strong>LINKEDIN<\/strong>:\u00a0<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=adelfa+e+serrano&amp;sort=date\">https:\/\/pubmed.ncbi.nlm.nih.gov\/?term=adelfa+e+serrano&amp;sort=date<\/a><br \/>\n<strong>Bibliography<\/strong>:\u00a0<a href=\"https:\/\/www.researchgate.net\/profile\/Adelfa-Serrano-Phd\">https:\/\/www.researchgate.net\/profile\/Adelfa-Serrano-Phd<\/a><br \/>\n<strong>Scholar<\/strong>:\u00a0<a href=\"https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Adelfa+E.+Serrano+Brizuela&amp;btnG\">https:\/\/scholar.google.com\/scholar?hl=en&amp;as_sdt=0%2C5&amp;q=Adelfa+E.+Serrano+Brizuela&amp;btnG<\/a>=<\/div><\/div>[vc_empty_space][vc_column_text]Malaria, caused by Plasmodium spp., remains as the most devastating parasitic disease affecting more than 225 million people worldwide. Nearly 1 million deaths are reported yearly, mostly children under the age of 5. Half of the world\u2019s population is considered at risk of malaria. Despite of ongoing efforts to generate novel antimalarials, find alternate vector controlling strategies and develop of an effective vaccine, the emergence and rapid spread of multidrug resistant Plasmodium coupled to the insecticide-resistant Anopheles strains, has resulted in re-emergence of this disease. There are currently no new drugs available and resistance has been reported for all of the antimalarials currently in use. Our previous and current work focuses in understanding mechanisms of underlying the development of Plasmodium drug resistance. The long-term goal of our research is to fully understand oxidative stress coping mechanisms and the glutathione biosynthetic pathway in the rodent malaria model, P. berghei in order to identify potential targets and drug resistance mechanisms to control the spread of malaria.[\/vc_column_text][vc_empty_space]<div id=\"ultimate-heading-259869d2d9e15b0ac\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-259869d2d9e15b0ac uvc-5263  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-259869d2d9e15b0ac h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-259869d2d9e15b0ac .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Our research is focused on genes from the glutathione biosynthesis and recycling pathway and those encoding ABC transporter proteins. These genes were previously associated to antimalarial resistance. Our approach to study this phenomenon is a combination of molecular and cellular biology techniques using Plasmodium berghei, which is a powerful rodent model for in vivo analyses. Following disruption of the genes of interest, both individually and in combination (double knockouts), phenotypical analyses including parasite development within the vertebrate (mouse) and invertebrate (mosquito) hosts are performed. In addition, sensitivity profiles to various anti-malarial drugs are determined both in vitro and in vivo. These studies contribute to a more comprehensive understanding of the oxidative stress coping mechanisms mediated by GSH and the role of ABC transporter proteins in parasite development providing new avenues for the development of novel antimalarial intervention strategies.<\/p>\n<p>Additional research interests include in vivo drug testing of antimalarial compounds as part of collaborative efforts.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-384669d2d9e15b0f9\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-384669d2d9e15b0f9 uvc-3657  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-384669d2d9e15b0f9 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-384669d2d9e15b0f9 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ol>\n<li>Rosado-Qui\u00f1ones AM, Col\u00f3n-Lorenzo EE, Pala ZR, Bosch J, Kudyba K, Kudyba H, Leed SE, Roncal N, Baerga-Ortiz A, Roche-Lima A, Gerena Y, Fidock DA, Roth A, Vega-Rodr\u00edguez J, Serrano AE. Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs. Antimicrob Agents Chemother. 2024 Apr 19:e0164323. doi: 10.1128\/aac.01643-23. Epub ahead of print. PMID: 38639491.<\/li>\n<li>Amador, LA;\u00a0Col\u00f3n-Lorenzo, EE;\u00a0Rodr\u00edguez, AD;\u00a0Serrano, AE. Probing the Antiplasmodial Properties of Plakortinic Acids C and D: An Uncommon Pair of Marine Peroxide-Polyketides Isolated from a Two-Sponge Association of Plakortis symbiotica and Xetospongia deweerdtae Collected near Puerto Rico. 2024. <em>Life<\/em>,\u00a0<em>14<\/em>(6), 684;\u00a0<a href=\"https:\/\/www.mdpi.com\/2075-1729\/14\/6\/684\">https:\/\/www.mdpi.com\/2075-1729\/14\/6\/684<\/a><\/li>\n<li>Amador, LA, Rodr\u00edguez, AD, Carmona-Sarabia, E, Col\u00f3n-Lorenzo, EE and Serrano, AE. Two Gracilioethers Containing a [2(5H)-Furanylidene]ethano- 2 ate Moiety and 9,10-Dihydroplakortone G: New Polyketides 3 from the Caribbean Marine Sponge<em> Plakortis halichondrioides<\/em>. 2024. <em> Sci., 13, x. <\/em><a href=\"https:\/\/www.mdpi.com\/2076-3417\/14\/1\/281\">https:\/\/www.mdpi.com\/2076-3417\/14\/1\/281<\/a><\/li>\n<li>Roche-Lima A, Rosado-Qui\u00f1ones AM, Feliu-Maldonado RA, Figueroa-Gispert MDM, D\u00edaz-Rivera J, D\u00edaz-Gonz\u00e1lez RG, Carrasquillo-Carrion K, Nieves BG, Col\u00f3n-Lorenzo EE, Serrano AE. Antimalarial Drug Combination Predictions Using the Machine Learning Synergy Predictor (MLSyPred\u00a9) tool. Acta Parasitol. 2024 Mar;69(1):415-425. doi: 10.1007\/s11686-023-00765-z. Epub 2024 Jan 2. PMID: 38165555; PMCID: PMC11001753.<\/li>\n<li>Derilus D, Rahman MZ, Serrano AE, Massey SE. Proteome size reduction in Apicomplexans is linked with loss of DNA repair and host redundant pathways. Infect Genet Evol 2021 Jan; 87:104642. PMID: 33296723, PMCID: PMC7936648, doi: 10.1016\/j.meegid.2020.104642.<\/li>\n<li>Col\u00f3n-Lorenzo EE, Col\u00f3n-L\u00f3pez DD, Vega-Rodr\u00edguez J, Dupin A, Fidock DA, Baerga-Ortiz A, Ortiz JG, Bosch J and <strong>Serrano AE <\/strong>(2020). Structure-Based Screening of <em>Plasmodium berghei <\/em>Glutathione S- Transferase Identifies CB-27 as a Novel Antiplasmodial Compound. Front. Pharmacol., 2020 Mar 17;11:246. doi: 10.3389\/fphar.2020.00246. eCollection 2020. PMID:32256353.<\/li>\n<li>Mayo-Santana, R, Rabionet, SE, Pe\u00f1a-Carro, L and Serrano, AE. Marvels and Shadows: Science and Education at the University of Puerto Rico School of Tropical Medicine under the Auspices of Columbia University: An Introduction. 2016. P R Health Sci J, 35 (2), 49-52. PMID: 27232864<\/li>\n<li>Urgaonkar, S; Cortese, J; Barker, R; Cromwell, M; <strong>Serrano, AE<\/strong>; Wirth, D; Clardy, J; Mazitschek, R. (2010). A Concise Silylamine Approach to 2-Amino-3-hydroxy-indoles with Potent <em>in vivo <\/em>Antimalaria Activity. Organic Letters<em>. <\/em>Org Lett. 2010 Aug 18. PMID: 20718474.<\/li>\n<li>Utter C, Serrano AE, Glod JW, Leibowitz MJ.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/28656007\/\">Association of Plasmodium falciparum with Human Endothelial Cells in vitro.\u00a0<\/a>Yale J Biol Med.2017 Jun;90(2):183-193.\u00a0eCollection 2017 Jun.\u00a0PubMed PMID: 28656007; PubMed Central PMCID: PMC5482297.<\/li>\n<li>Pad\u00edn-Irizarry V, Col\u00f3n-Lorenzo EE, Vega-Rodr\u00edguez J, Castro Mdel R, Gonz\u00e1lez-M\u00e9ndez R, Ayala-Pe\u00f1a S, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26952808\/\">Glutathione-deficient Plasmodium berghei parasites exhibit growth delay and nuclear DNA damage.\u00a0<\/a>Free Radic Biol Med.\u00a02016 Jun;95:43-54.\u00a0doi: 10.1016\/j.freeradbiomed.2016.02.032.\u00a0Epub 2016 Mar 4.\u00a0PubMed PMID: 26952808; PubMed Central PMCID: PMC4934901.<\/li>\n<li>Mayo-Santana R, Rabionet SE, Pe\u00f1a-Carro L, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/27232864\/\">Marvels and Shadows: Science and Education at the University of Puerto Rico School of Tropical Medicine under the Auspices of Columbia University: An Introduction.\u00a0<\/a>P R Health Sci J.\u00a02016 Jun;35(2):49-52.\u00a0PubMed PMID: 27232864.<\/li>\n<li>Rijpma SR, van der Velden M, Gonz\u00e1lez-Pons M, Annoura T, van Schaijk BC, van Gemert GJ, van den Heuvel JJ, Ramesar J, Chevalley-Maurel S, Ploemen IH, Khan SM, Franetich JF, Mazier D, de Wilt JH, Serrano AE, Russel FG, Janse CJ, Sauerwein RW, Koenderink JB, Franke-Fayard BM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26332724\/\">Multidrug ATP-binding cassette transporters are essential for hepatic development of Plasmodium sporozoites.\u00a0<\/a>Cell Microbiol.\u00a02016 Mar;18(3):369-83.\u00a0doi: 10.1111\/cmi.12517.\u00a0Epub 2015 Nov 10.\u00a0PubMed PMID: 26332724; PubMed Central PMCID: PMC4984424.<\/li>\n<li>Vega-Rodr\u00edguez J, Pastrana-Mena R, Crespo-Llad\u00f3 KN, Ortiz JG, Ferrer-Rodr\u00edguez I, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/26010448\/\">Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin.\u00a0<\/a>PLoS One.\u00a02015;10(5):e0128212.\u00a0doi: 10.1371\/journal.pone.0128212.\u00a0eCollection 2015.\u00a0PubMed PMID: 26010448; PubMed Central PMCID: PMC4444287.Comer E, Beaudoin JA, Kato N, Fitzgerald ME, Heidebrecht RW, Lee Md 4th, Masi D, Mercier M, Mulrooney C, Muncipinto G, Rowley A, Crespo-Llado K, Serrano AE, Lukens AK, Wiegand RC, Wirth DF, Palmer MA, Foley MA, Munoz B, Scherer CA, Duvall JR, Schreiber SL.<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/25211597\/\">Diversity-oriented synthesis-facilitated medicinal chemistry: toward the development of novel antimalarial agents.\u00a0<\/a>J Med Chem.\u00a02014 Oct 23;57(20):8496-502.\u00a0doi: 10.1021\/jm500994n.\u00a0Epub 2014 Oct 13.\u00a0PubMed PMID: 25211597; PubMed Central PMCID: PMC4207553.<\/li>\n<\/ol>\n<ol start=\"39\">\n<li>le Roux D, Burger PB, Niemand J, Grobler A, Urb\u00e1n P, Fern\u00e0ndez-Busquets X, Barker RH, Serrano AE, I Louw A, Birkholtz LM.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/24596666\/\">Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites.<\/a>Int J Parasitol Drugs Drug Resist.\u00a02014 Apr;4(1):28-36.\u00a0doi: 10.1016\/j.ijpddr.2013.11.003.\u00a0eCollection 2014 Apr.\u00a0PubMed PMID: 24596666; PubMed Central PMCID: PMC3940083.<\/li>\n<li>Dong CK, Urgaonkar S, Cortese JF, Gamo FJ, Garcia-Bustos JF, Lafuente MJ, Patel V, Ross L, Coleman BI, Derbyshire ER, Clish CB, Serrano AE, Cromwell M, Barker RH Jr, Dvorin JD, Duraisingh MT, Wirth DF, Clardy J, Mazitschek R.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22195562\/\">Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.\u00a0<\/a>Chem Biol.\u00a02011 Dec 23;18(12):1602-10.\u00a0doi: 10.1016\/j.chembiol.2011.09.016.\u00a0PubMed PMID: 22195562; PubMed Central PMCID: PMC3474356.<\/li>\n<li>Gerena Y, Gonzalez-Pons M, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/22015734\/\">Cytofluorometric detection of rodent malaria parasites using red-excited fluorescent dyes.<\/a>Cytometry A.\u00a02011 Nov;79(11):965-72.\u00a0doi: 10.1002\/cyto.a.21119.\u00a0Epub 2011 Aug 25.\u00a0PubMed PMID: 22015734; PubMed Central PMCID: PMC3210507.<\/li>\n<li>Barker RH Jr, Urgaonkar S, Mazitschek R, Celatka C, Skerlj R, Cortese JF, Tyndall E, Liu H, Cromwell M, Sidhu AB, Guerrero-Bravo JE, Crespo-Llado KN, Serrano AE, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman BI, Angulo-Barturen I, Jim\u00e9nez-D\u00edaz MB, Mag\u00e1n N, Gomez V, Ferrer S, Mart\u00ednez MS, Wittlin S, Papastogiannidis P, O&#8217;Shea T, Klinger JD, Bree M, Lee E, Levine M, Wiegand RC, Munoz B, Wirth DF, Clardy J, Bathurst I, Sybertz E.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/21422215\/\">Aminoindoles, a novel scaffold with potent activity against Plasmodium falciparum.\u00a0<\/a>Antimicrob Agents Chemother.\u00a02011 Jun;55(6):2612-22.\u00a0doi: 10.1128\/AAC.01714-10.\u00a0Epub 2011 Mar 21.\u00a0PubMed PMID: 21422215; PubMed Central PMCID: PMC3101419.<\/li>\n<li>Booker ML, Bastos CM, Kramer ML, Barker RH Jr, Skerlj R, Sidhu AB, Deng X, Celatka C, Cortese JF, Guerrero Bravo JE, Crespo Llado KN, Serrano AE, Angulo-Barturen I, Jim\u00e9nez-D\u00edaz MB, Viera S, Garuti H, Wittlin S, Papastogiannidis P, Lin JW, Janse CJ, Khan SM, Duraisingh M, Coleman B, Goldsmith EJ, Phillips MA, Munoz B, Wirth DF, Klinger JD, Wiegand R, Sybertz E.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20702404\/\">Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.\u00a0<\/a>J Biol Chem.\u00a02010 Oct 22;285(43):33054-33064.\u00a0doi: 10.1074\/jbc.M110.162081.\u00a0Epub 2010 Aug 11.\u00a0PubMed PMID: 20702404; PubMed Central PMCID: PMC2963363.<\/li>\n<li>Urgaonkar S, Cortese JF, Barker RH, Cromwell M, Serrano AE, Wirth DF, Clardy J, Mazitschek R.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20718474\/\">A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity.\u00a0<\/a>Org Lett.\u00a02010 Sep 17;12(18):3998-4001.\u00a0doi: 10.1021\/ol101566h.\u00a0PubMed PMID: 20718474; PubMed Central PMCID: PMC7479540.<\/li>\n<li>Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodr\u00edguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/20573956\/\">Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito.\u00a0<\/a>J Biol Chem.\u00a02010 Aug 27;285(35):27045-27056.\u00a0doi: 10.1074\/jbc.M110.122275.\u00a0Epub 2010 Jun 23.\u00a0PubMed PMID: 20573956; PubMed Central PMCID: PMC2930704.<\/li>\n<li>Col\u00f3n-Lorenzo EE, Serrano AE, Nicholas Jr. HB, Wymore T, Ropelewski AJ, Gonz\u00e1lez-M\u00e9ndez R. The Plasmodium glutathione S-transferase: Bioinformatics Characterization and Classification into the Sigma Class. (2010). In: Fred A, Filipe J, Gamboa H, editors. Proceedings of Bioinformatics 2010, 1st International Conference on Bioinformatics, pp 173-180. Lisbon, Portugal, ISBN: 978-989-674-019-1<\/li>\n<li>Vega-Rodr\u00edguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodr\u00edguez-Orengo JF, Srinivasan P, Jacobs-Lorena M, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19229315\/\">The glutathione biosynthetic pathway of Plasmodium is essential for mosquito transmission.\u00a0<\/a>PLoS Pathog.2009 Feb;5(2):e1000302.\u00a0doi: 10.1371\/journal.ppat.1000302.\u00a0Epub 2009 Feb 20.\u00a0PubMed PMID: 19229315; PubMed Central PMCID: PMC2636896.<\/li>\n<li>Gonz\u00e1lez-Pons M, Szeto AC, Gonz\u00e1lez-M\u00e9ndez R, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/19118502\/\">Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in Plasmodium berghei.\u00a0<\/a>Malar J.\u00a02009 Jan 2;8:1.\u00a0doi: 10.1186\/1475-2875-8-1.\u00a0PubMed PMID: 19118502; PubMed Central PMCID: PMC2630995.<\/li>\n<li>Ferrer-Rodr\u00edguez I, P\u00e9rez-Rosado J, Gervais GW, Peters W, Robinson BL, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/15040683\/\">Plasmodium yoelii: identification and partial characterization of an MDR1 gene in an artemisinin-resistant line.\u00a0<\/a>J Parasitol.\u00a02004 Feb;90(1):152-60.\u00a0doi: 10.1645\/GE-3225.\u00a0PubMed PMID: 15040683.<\/li>\n<li>Szeto AC, P\u00e9rez-Rosado J, Ferrer-Rodr\u00edguez I, Vega J, Torruella-Thillet C, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/14564508\/\">Identification and expression analysis of ABC genes in Plasmodium yoelii and P. berghei.\u00a0<\/a>Parasitol Res.\u00a02004 Jan;92(1):1-11.\u00a0doi: 10.1007\/s00436-003-1001-8.\u00a0Epub 2003 Oct 17.\u00a0PubMed PMID: 14564508.<\/li>\n<li>P\u00e9rez-Rosado J, Gervais GW, Ferrer-Rodr\u00edguez I, Peters W, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/12594957\/\">Plasmodium berghei: analysis of the gamma-glutamylcysteine synthetase gene in drug-resistant lines.\u00a0<\/a>Exp Parasitol.\u00a02002 Aug;101(4):175-82.\u00a0doi: 10.1016\/s0014-4894(02)00138-8.\u00a0PubMed PMID: 12594957.<\/li>\n<li>Carrasquilla G, Banguero M, Sanchez P, Carvajal F, Barker RH Jr, Gervais GW, Algarin E, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10761738\/\">Epidemiologic tools for malaria surveillance in an urban setting of low endemicity along the Colombian Pacific coast.\u00a0<\/a>Am J Trop Med Hyg.\u00a02000 Jan;62(1):132-7.\u00a0doi: 10.4269\/ajtmh.2000.62.132.\u00a0PubMed PMID: 10761738.<\/li>\n<li>Ferrer-Rodr\u00edguez I, V\u00e1zquez GJ, C\u00f3rdova GJ, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/10461315\/\">Diagnosis of malaria by polymerase chain reaction.\u00a0<\/a>P R Health Sci J.\u00a01999 Jun;18(2):99-103.\u00a0PubMed PMID: 10461315.<\/li>\n<li>Serrano AE, Robinson BL, Peters W, Trujillo-Nev\u00e1rez K.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9920047\/\">Plasmodium berghei and Plasmodium yoelii: molecular karyotypes of drug-resistant lines.\u00a0<\/a>Exp Parasitol.\u00a01999 Jan;91(1):93-6.\u00a0doi: 10.1006\/expr.1999.4345.\u00a0PubMed PMID: 9920047.<\/li>\n<li>Gervais GW, Trujillo K, Robinson BL, Peters W, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/9920046\/\">Plasmodium berghei: identification of an mdr-like gene associated with drug resistance.\u00a0<\/a>Exp Parasitol.\u00a01999 Jan;91(1):86-92.\u00a0doi: 10.1006\/expr.1999.4344.\u00a0PubMed PMID: 9920046.<\/li>\n<li>Ramajo Martin, V., L\u00f3pez Aban, J., A.E. Serrano, A. Oleaga P\u00e9rez and A. Muro Alvarez. 1996. A long term study on the prevalence of gastrointestinal, hepatic and pulmonary parasitism in sheep from Salamanca province, Western Spain. Research &amp; Review in Parasitology. 56:173-177.<\/li>\n<li>Ramajo Martin, V., L\u00f3pez Aban, J., A.E. Serrano, A. Oleaga P\u00e9rez and A. Muro Alvarez. 1995. A long term study on the prevalence of gastrointestinal, hepatic and pulmonary parasitism in adult cattle from Salamanca province, Western Spain. Research &amp; Review in Parasitology. 55:231-234.<\/li>\n<li>Wilson CM, Serrano AE, Wasley A, Bogenschutz MP, Shankar AH, Wirth DF.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/2658061\/\">Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.\u00a0<\/a>1989 Jun 9;244(4909):1184-6.\u00a0doi: 10.1126\/science.2658061.\u00a0PubMed PMID: 2658061.<\/li>\n<li>Hillyer GV, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3091677\/\">Fractionation of Fasciola hepatica tegument antigens and their application to the serodiagnosis of experimental fascioliasis by the enzyme-linked immunosorbent assay.\u00a0<\/a>J Helminthol.\u00a01986 Sep;60(3):173-8.\u00a0doi: 10.1017\/s0022149x00026055.\u00a0PubMed PMID: 3091677.<\/li>\n<li>Hillyer GV, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/6404188\/\">The antigens of Paragonimus westermani, Schistosoma mansoni, and Fasciola hepatica adult worms. Evidence for the presence of cross-reactive antigens and for cross-protection to Schistosoma mansoni infection using antigens of Paragonimus westermani.\u00a0<\/a>Am J Trop Med Hyg.\u00a01983 Mar;32(2):350-8.\u00a0doi: 10.4269\/ajtmh.1983.32.350.\u00a0PubMed PMID: 6404188.<\/li>\n<li>Hillyer GV, Serrano AE.\u00a0<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/7077096\/\">Cross protection in infections due to Schistosoma mansoni using tegument antigens of Fasciola hepatica.\u00a0<\/a>J Infect Dis.\u00a01982 May;145(5):728-32.\u00a0doi: 10.1093\/infdis\/145.2.728.\u00a0PubMed PMID: 7077096.<\/li>\n<\/ol>\n<p><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-810169d2d9e15b195\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-810169d2d9e15b195 uvc-9991  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-810169d2d9e15b195 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Book Chapters<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-810169d2d9e15b195 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Anti-protozoan drugs. A. Muro, A.E. Serrano,and J.L. P\u00e9rez de Arellano. Chapter 22, pp. 331-343. In: Gu\u00eda de Autoformaci\u00f3n en Enfermedades Infecciosas&#8221;, Madrid, Espa\u00f1a<\/li>\n<li>Anti-helminthic drugs. A. Muro, A.E. Serrano,and J.L. P\u00e9rez de Arellano. Chapter 23, pp. 345-353.In: Gu\u00eda de Autoformaci\u00f3n en Enfermedades Infecciosas&#8221;, Madrid, Espa\u00f1a<\/li>\n<\/ul>\n<p>This book received \u201cEl Medico&#8221; Award, XIII Edition, Best Medical Book 1st. prize\u201d<\/p>\n<ul>\n<li>Vega-Rodr\u00edguez J, Franke-Fayard B, Dinglasan RR, Janse CJ, Pastrana-Mena R, Waters AP, Coppens I, Rodr\u00edguez-Orengo JF, Jacobs-Lorena M, and Serrano AE. (2009). The glutathione biosynthetic pathway of <em>Plasmodium<\/em> is essential for mosquito transmission. PLoS Pathog. Feb;5(2):e1000302. Epub 2009 Feb 20 PMID: 19229315. PMCID: PMC2636896.<\/li>\n<li>Pastrana-Mena R, Dinglasan RR, Franke-Fayard B, Vega-Rodriguez J, Fuentes-Caraballo M, Baerga-Ortiz A, Coppens I, Jacobs-Lorena M, Janse CJ, Serrano AE. (2010). Glutathione reductase-null malaria parasites have normal blood stage growth but arrest during development in the mosquito. (2010). J Biol Chem. 285: 27045 &#8211; 27056 2010, Epub 2010 Jun 23. PMID: 20573956. PMCID: PMC2930704.<\/li>\n<li>Vega-Rodr\u00edguez J, Pastrana-Mena R, Crespo-Llad\u00f3 KN, Ortiz JG, Ferrer-Rodr\u00edguez I, Serrano AE. Implications of Glutathione Levels in the Plasmodium berghei Response to Chloroquine and Artemisinin. PLoS One. 2015 May 26;10(5):e0128212. doi: 10.1371\/journal.pone.0128212. eCollection2015. PMID: 26010448. PMCID: PMC4444287.<\/li>\n<li>Pad\u00edn-Irizarry V, Col\u00f3n-Lorenzo E, Vega-Rodr\u00edguez J, Castro MR, Gonzalez-M\u00e9ndez, R, Ayala-Pe\u00f1a S, Serrano AE. Glutathione-Deficient <em>Plasmodium berghei<\/em> Parasites Exhibit Growth Delay and NuclearDNA Damage. 2016. Free Radic Biol Med. 2016 Mar 4;95:43-54. doi: 10.1016\/j.freeradbiomed.2016.02.032. PMID: 26952808.<\/li>\n<li>Wilson CM, Serrano AE, Wasley A, Bogenschutz MP, Shankar AH, and Wirth DF. Amplification of a gene related to mammalian mdr genes in drug-resistant <em>Plasmodium falciparum<\/em>. (1989). Science 244:1185- 1186. PMID: 2658061.<\/li>\n<li>Gervais G, Trujillo-Nev\u00e1rez K, Robinson BL, Peters WA, and Serrano AE. <em>Plasmodium berghei:<\/em> Identification of an mdr-like gene associated with drug resistance. (1999). Exp Parasitol 91: 86-92. PMID: 9920046<\/li>\n<li>Gonzalez-Pons M, Szeto AC, Gonzalez-Mendez R, and Serrano AE. (Identification and bioinformatic characterization of a multidrug resistance associated protein (ABCC) gene in <em>Plasmodium berghei<\/em>. (2009). Malar J. Jan 2;8(1): 1. PMID: 19118502. PMCID: PMC2630995.<\/li>\n<li>Rijpma SR, van der Velden M, Gonz\u00e1lez-Pons M, Annoura T, van Schaijk BC, van Gemert GJ, van den Heuvel JJ, Ramesar J, Chevalley-Maurel S, Ploemen IH, Khan SM, Franetich JF, Mazier D, de Wilt JH, Serrano AE, Russel FG, Janse CJ, Sauerwein RW, Koenderink JB, Franke-Fayard BM. Multidrug ABC transporters are essential for hepatic development of <em>Plasmodium<\/em> sporozoites. Cell Microbiol. 2015 Aug 29. doi: 10.1111\/cmi.12517. PMID: 26332724. PMCID:<\/li>\n<li>Hillyer GV and Serrano, AE.1986. Fractionation of <em>Fasciola hepatica<\/em> tegument antigens and their application to the serodiagnosis of experimental fascioliasis by the enzyme-linked immunosorbent assay. J Helminth 60:173-178. PMID: 3091677.<\/li>\n<li>Hillyer GV and Serrano AE. Cross-protection in infections due to Sc<em>histosoma mansoni <\/em>using tegument antigens of Fasciola hepatica. (1982). J Infec Dis 145: 728-732. PMID: 7077096.<\/li>\n<li>Hillyer GV and Serrano AE. The antigens of adult worms. Evidence for the presence of cross-protection to Schistosoma mansoni infection using antigens of <em>Paragonimus westermani<\/em>. (1983). Am J Trop Med Hyg 32: 350-358. PMID: 6404188.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_column_text]Malaria, caused by Plasmodium spp., remains as the most devastating parasitic disease affecting more than 225 million people worldwide. Nearly 1 million deaths are reported yearly, mostly children under the age of 5. Half of the world\u2019s population is considered at risk of malaria. Despite of ongoing efforts to generate novel&hellip;<\/p>\n","protected":false},"featured_media":1173,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-813","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team\/813","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=813"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/1173"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=813"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/dt_team_category?post=813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}