{"id":2283,"date":"2024-03-01T09:50:03","date_gmt":"2024-03-01T13:50:03","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/micro\/?p=2283"},"modified":"2024-09-26T09:55:31","modified_gmt":"2024-09-26T13:55:31","slug":"gut-microbiota-composition-is-associated-with-the-efficacy-of-delta-24-rgdox-in-malignant-gliomas","status":"publish","type":"post","link":"https:\/\/md.rcm.upr.edu\/micro\/2024\/03\/01\/gut-microbiota-composition-is-associated-with-the-efficacy-of-delta-24-rgdox-in-malignant-gliomas\/","title":{"rendered":"Gut microbiota composition is associated with the efficacy of Delta-24-RGDOX in malignant gliomas"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_single_image image=&#8221;2284&#8243; img_size=&#8221;full&#8221; css=&#8221;&#8221;][vc_column_text]Glioblastoma, the most common primary brain tumor, has a 6.8%\u00a0survival rate\u00a05 years post diagnosis. Our team developed an\u00a0oncolytic adenovirus\u00a0with an OX-40L\u00a0expression cassette\u00a0named Delta-24-RGDOX. While studies have revealed the interaction between the\u00a0gut microbiota\u00a0and\u00a0immunotherapy\u00a0agents, no studies link the\u00a0gut microbiota\u00a0with viroimmunotherapy efficacy in glioblastoma. We hypothesize that gut bacterial signatures will be associated with oncolytic\u00a0viral therapy\u00a0efficacy. To test this hypothesis, we evaluated the changes in\u00a0gut microbiota\u00a0in two mouse cohorts: (1) GSC-005 glioblastoma-bearing mice treated orally with\u00a0indoximod, an\u00a0immunotherapeutic agent, or with Delta-24-RGDOX by\u00a0intratumoral injection\u00a0and (2) a mouse cohort harboring GL261-5 tumors used to mechanistically evaluate the importance of CD4+\u00a0T\u00a0cells in relation to viroimmunotherapy efficacy.\u00a0Microbiota\u00a0assessment indicated significant differences in the structure of the gut bacterial communities in\u00a0viroimmunotherapy-treated animals with higher survival compared with control or indoximod-treated animals. Moreover, viroimmunotherapy-treated mice with prolonged survival had a higher abundance of\u00a0Bifidobacterium. The CD4+\u00a0T\u00a0cell depletion was associated with gut\u00a0dysbiosis, lower mouse survival, and lower antitumor efficacy of the therapy. These findings suggest that microbiota modulation along the gut-glioma axis contributes to the efficacy and survival of viroimmunotherapy treated animals.[\/vc_column_text][vc_btn title=&#8221;Read complete article&#8221; color=&#8221;black&#8221; size=&#8221;sm&#8221; css=&#8221;&#8221; link=&#8221;url:https%3A%2F%2Fwww.sciencedirect.com%2Fscience%2Farticle%2Fpii%2FS2950329924000298%23%3A~%3Atext%3DOriginal%2520Article-%2CGut%2520microbiota%2520composition%2520is%2520associated%2520with%2520the%2520efficacy%2520of%2C24%252DRGDOX%2520in%2520malignant%2520gliomas%26text%3DGlioblastoma%252C%2520the%2520most%2520common%2520primary%2Cnamed%2520Delta%252D24%252DRGDOX.&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Glioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and immunotherapy agents, no studies link the gut microbiota with viroimmunotherapy efficacy in glioblastoma.<\/p>\n","protected":false},"author":1,"featured_media":1282,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-2283","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-news","category-6","description-off"],"aioseo_notices":[],"jetpack_featured_media_url":"https:\/\/md.rcm.upr.edu\/micro\/wp-content\/uploads\/sites\/22\/2020\/11\/Natalie.jpg","_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/posts\/2283","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/comments?post=2283"}],"version-history":[{"count":3,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/posts\/2283\/revisions"}],"predecessor-version":[{"id":2287,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/posts\/2283\/revisions\/2287"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media\/1282"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/media?parent=2283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/categories?post=2283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/micro\/wp-json\/wp\/v2\/tags?post=2283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}