{"id":1528,"date":"2025-05-19T11:57:29","date_gmt":"2025-05-19T15:57:29","guid":{"rendered":"https:\/\/md.rcm.upr.edu\/pharmacology\/?post_type=dt_team&#038;p=1528"},"modified":"2025-05-19T11:59:27","modified_gmt":"2025-05-19T15:59:27","slug":"dr-yamil-gerena","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/pharmacology\/dt_team\/dr-yamil-gerena\/","title":{"rendered":"Dr. Yamil Gerena"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-822869d790f4be91e\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-822869d790f4be91e uvc-8312 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-822869d790f4be91e h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Yamil Gerena<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-822869d790f4be91e .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-03beb2dd1fc006d540ec986987961901.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-03beb2dd1fc006d540ec986987961901.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-03beb2dd1fc006d540ec986987961901 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-03beb2dd1fc006d540ec986987961901 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-03beb2dd1fc006d540ec986987961901 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-content\/uploads\/sites\/21\/2023\/01\/yamil-gerena.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-content\/uploads\/sites\/21\/2023\/01\/yamil-gerena.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/pharmacology\/welcome\/yamil-gerena\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Yamil Gerena, PhD\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-1084\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-1084 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:yamil.gerena@upr.edu\">yamil.gerena@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2541\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2541 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">University of Puerto Rico<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-4525\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-4525 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787-758-2525 Ext. 1249<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">University of Puerto Rico, R\u00edo Piedras Campus B.S. Chemistry<\/span><\/li>\n<li><span style=\"color: #ffffff;\">University of Puerto Rico, School of Medicine Ph.D. Pharmacology<\/span><\/li>\n<li><span style=\"color: #ffffff;\">University of Puerto Rico, School of Medicine Post Doc Immunology\/Molecular Biology<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-252869d790f4c122a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-252869d790f4c122a uvc-2405  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-252869d790f4c122a h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-252869d790f4c122a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">The emphasis of my current work has focused on the mechanisms involved in the generation of insulin resistance and HIV-Associated Neurocognitive Disorders (HAND) in a population of HIV-seropositive patients. In addition, we investigated the role of inflammatory cytokines and the Renin Angiotensin System (RAS) in HIV and cardiovascular diseases using Flow Cytometry. I have extensive experience in Flow Cytometry and have spent more than 22 years working with this revolutionary technique. In addition, I have a broad background in molecular biology and fluorometric techniques, with specific training and expertise in molecular cloning, DNA, mRNA, and protein isolation, RT-PCR, stable transfection in cells, western blot, and cytofluor analysis.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-10569d790f4c127e\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-10569d790f4c127e uvc-4244  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-10569d790f4c127e h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-10569d790f4c127e .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>1. Gerena Y, Menendez-Delmestre R, Delgado-Nieves A, Velez J, Mendez-Alvarez J, Sierra JE, Skolasky RL, Henderson L, Nath A, Wojna V. (2019). The Release of Soluble Insulin Receptor from Neurons by Cerebrospinal Fluid from Patients with Neurocognitive Dysfunction and HIV Infection. Front Neurol. Accepted. Front Neurol.10:285. PMCID: PMC6443904.<br \/>\n2. Gerena Y, Lozada JG, Collazo BJ, M\u00e9ndez-\u00c1lvarez J, M\u00e9ndez-Estrada J, De Mello WC. (2017). Losartan counteracts the effects of cardiomyocyte swelling on glucose uptake and insulin receptor substrate-1 levels. Peptides. 96:38-43.<br \/>\n3. De Mello WC, Gerena Y, Ayala-Pe\u00f1a S. (2017). Angiotensins and Huntington\u2019s Disease: A Study on Immortalized Progenitor Striatal Cell Lines. Front Endocrinol . 24;8:108.<br \/>\n4. T Humphries-Bickley, L Castillo-Pichardo, E Hernandez-O\u2019Farrill, L Borrero-Garcia, I Forestier-Roman, Y Gerena, LA Cubano, CP Vlaar, S Dharmawardhane. Characterization of a Dual Rac\/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer. Molecular Cancer Therapeutics. 16(5):805-818.<br \/>\n5. Ferrario CM, Frohlich ED, Gerena Y. (2017). Walmor C. De Mello: \u201cYour Heart Is Still With Us\u201d. Hypertension. 2017 Jun;69(6):992-993.<br \/>\n6. De Mello WC, Gerena Y. (2017). Measurement of Cardiac Angiotensin II by Immunoassays, HPLC-Chip\/Mass Spectrometry, and Functional Assays. Methods Mol Biol. 1527:127-137.<br \/>\n7. Rivera Rivera A, Castillo-Pichardo L, Gerena Y, Dharmawardhane S. (2016). Anti-Breast Cancer Potential of Quercetin via the Akt\/AMPK\/Mammalian Target of Rapamycin (mTOR) Signaling Cascade. PLoS One. 11(6): e0157251.<br \/>\n8. Delgado-V\u00e9lez M, B\u00e1ez-Pag\u00e1n CA, Gerena Y, Quesada O, Santiago-P\u00e9rez LI, Cap\u00f3-V\u00e9lez CM, Wojna V, Mel\u00e9ndez L, Le\u00f3n-Rivera R, Silva W and Lasalde-Dominicci JA. (2015). The \u03b17-nicotinic receptor is upregulated in immune cells from HIV-seropositive women: consequences to the cholinergic anti-inflammatory response. Clinical &amp; Translational Immunology. 4, e53.<br \/>\n9. Gerena Y, Menendez-Delmestre R, Skolasky RL, Hechavarria RM, Perez S, Hilera C, Gonzalez C, Nath A, Wojna V. (2015). Soluble Insulin Receptor as a Source of Insulin Resistance and Cognitive Impairment in HIV-seropositive Women. J Neurovirol. 21(2):113-9.<br \/>\n10. Cantres-Rosario Y, Plaud-Valentin M, Gerena Y, Skolasky RL, Wojna V, Melendez LM. (2013). Cathepsin B and cystatin B in HIV-seropositive women are associated with infection and HIV-1-associated neurocognitive disorders. AIDS. 27(3):347-56.<\/li>\n<\/ul>\n<p><strong>For a complete list of publications, please go to:<\/strong><\/p>\n<p><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/1Pip7LH5HO05t\/bibliography\/47558450\/public\/?sort=date&amp;direction=ascendin\">http:\/\/www.ncbi.nlm.nih.gov\/sites\/myncbi\/1Pip7LH5HO05t\/bibliography\/47558450\/public\/?sort=date&amp;direction=ascendin<\/a><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Yamil Gerena, Ph.D.<\/p>\n","protected":false},"featured_media":1308,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[34],"class_list":["post-1528","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-34","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team\/1528","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/comments?post=1528"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/media\/1308"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/media?parent=1528"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team_category?post=1528"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}