{"id":873,"date":"2016-03-07T19:44:04","date_gmt":"2016-03-07T19:44:04","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/pharmacology\/?post_type=dt_team&#038;p=873"},"modified":"2023-05-22T13:16:47","modified_gmt":"2023-05-22T17:16:47","slug":"dra-sylvette-ayala","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/pharmacology\/dt_team\/dra-sylvette-ayala\/","title":{"rendered":"Dr. Sylvette Ayala"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-394169d05296a801b\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-394169d05296a801b uvc-2213 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-394169d05296a801b h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Sylvette Ayala Pe\u00f1a<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-394169d05296a801b .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-4b2b9bb1273d4a9280d5cc1f477b1dbb.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-4b2b9bb1273d4a9280d5cc1f477b1dbb.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-4b2b9bb1273d4a9280d5cc1f477b1dbb .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-4b2b9bb1273d4a9280d5cc1f477b1dbb .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-4b2b9bb1273d4a9280d5cc1f477b1dbb alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-content\/uploads\/sites\/21\/2016\/03\/SylvetteAyala.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-content\/uploads\/sites\/21\/2016\/03\/SylvetteAyala.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/pharmacology\/dt_team\/dra-sylvette-ayala\/sylvetteayala\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Sylvette Ayala\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8018\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8018 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:sylvette.ayala@upr.edu\">sylvette.ayala@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-1147\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-1147 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Room A-335<\/span><br \/>\n<span style=\"color: #ffffff;\">Guillermo Arbona Irizarry Building<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR 00936<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3046\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3046 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787-758-2525 Ext. 1374 (office)\/1375 (lab)<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">BS, University of Puerto Rico R\u00edo Piedras Campus<\/span><\/li>\n<li><span style=\"color: #ffffff;\">MT (Medical Technology), University of Puerto Rico Medical Sciences Campus<\/span><\/li>\n<li><span style=\"color: #ffffff;\">MS (Microbiology), University of Puerto Rico Medical Sciences Campus<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph.D. (Biochemistry and Molecular Biology), University of Texas Medical Branch at Galveston<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoctoral Fellowship, Oxidative stress and Mitochondria, Dr. Ben Van Houten\u2019s laboratory, Sealy Center for Molecular Science, TX<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoctoral Fellowship, Aging and Mitochondria, Dr. John Papaconstantinou\u2019s laboratory, UTMB<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Visiting Professor, Mitochondria and Bioenergetics, Dr. Julie K. Andersen\u2019s and David Nicholls\u2019 laboratories, Buck Institute on Aging Research, CA<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-292769d05296aac2a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-292769d05296aac2a uvc-956  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-292769d05296aac2a h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH AREAS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-292769d05296aac2a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Mitochondrial DNA Damage and Repair<br \/>\nNeurodegeneration and Huntington\u2019s disease<br \/>\nAging and age-associated metabolic disorders<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-858069d05296aac84\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-858069d05296aac84 uvc-4044  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-858069d05296aac84 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-858069d05296aac84 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Huntington\u2019s Disease (HD) is a neurodegenerative disorder for which no treatment has been identified to prevent, limit, or cure symptoms of involuntary choreiform movements, behavioral abnormalities, dementia, and motor dysfunction as a result of neuronal loss in the striatum and cerebral cortex. Although it is known that HD is caused by mutations in the huntingtin gene, the causality of this mutation in the mechanism of neuronal loss remains unknown. Compelling evidence suggests that increased oxidative stress and mitochondrial dysfunction contribute to the pathophysiology of HD, thus, a better understanding of why mitochondrial dysfunction may arise during HD neurodegeneration could provide the basis for the development of new pharmacological interventions to delay disease onset and progression. Our experimental plan is based on testing a hypothesis that targets the main endonuclease, APE1, associated with repair of mitochondrial DNA (mtDNA) against oxidative stress as a potential target to prevent HD. To test our hypothesis, we apply cellular, biochemical and molecular approaches using both in vitro and in vivo experimental models. We also test small molecules with antioxidant activity as interventions to prevent onset and\/or progression of the disease. Because aging is the main risk factor for chronic diseases and is associated with increased DNA damage and decreased DNA repair capacity, we are also studying the role of mitochondria in diabetes, an age-associated disorder, and testing pharmacological interventions that may protect mtDNA integrity and mitochondrial function.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-455369d05296aace2\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-455369d05296aace2 uvc-7028  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-455369d05296aace2 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-455369d05296aace2 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">2021:<\/p>\n<ul>\n<li>Nadalutti CA, Ayala-Pe\u00f1a S, Santos JH. Mitochondrial DNA damage as driver of cellular outcomes. Am J Physiol Cell Physiol. 2021 Dec 22. doi: 10.1152\/ajpcell.00389.2021. Epub ahead of print. PMID: 34936503.<\/li>\n<\/ul>\n<p>2020:<\/p>\n<ul>\n<li>Lozada-Delgado, J, Torres-Ramos, C, and Ayala-Pe\u00f1a, S. (2020). Aging, oxidative stress, mitochondrial dysfunction and the liver. 10.1016\/B978-0-12-818698-5.00004-3.<\/li>\n<\/ul>\n<p>2019:<\/p>\n<ul>\n<li>Parodi-Rull\u00e1n R, Chapa-Dubocq X, Guzm\u00e1n-Hern\u00e1ndez R, Jang S, A Torres-Ramos C, Ayala-Pe\u00f1a S, Javadov S. The role of adenine nucleotide translocase in the assembly of respiratory supercomplexes in cardiac cells. Cells. 2019 Oct 13;8(10). pii: E1247. doi: 10.3390\/cells8101247.<\/li>\n<\/ul>\n<p>2018:<\/p>\n<ul>\n<li>Preston AM, Rodr\u00edguez-Orengo J, Gonz\u00e1lez-Sep\u00falveda L, Ayala-Pe\u00f1a S, Maldonado-Maldonado E. Effect of Housing Type on 25 OH Vitamin D in Serum of Rhesus Monkeys. PR Health Sci J.\u00a02018 Jun;37(2):124-127. PMID: 29905924<\/li>\n<\/ul>\n<p>2017:<\/p>\n<ul>\n<li>Ballista-Hernandez J, Martinez-Ferrer M, Velez R, Climent C, Sanchez-Vazquez MM, Torres C, Rodriguez-Munoz A,\u00a0Ayala-Pe\u00f1a S, Torres-Ramos CA. Mitochondrial DNA Integrity is Maintained by APE1 in Carcinogen-induced Colorectal Cancer.\u00a0Mol Cancer Res.2017 Mar 30. pii: molcanres.0218.2016. doi: 10.1158\/1541-7786.MCR-16-0218. PMID: 28360037<\/li>\n<li>De Mello WC, Gerena Y and\u00a0Ayala-Pe\u00f1a S. Angiotensins and Huntington\u2019s disease: A study on Immortalized Progenitor Striatal Cell Lines.\u00a0Frontiers in Endocrinology\u00a0May 2017 doi: 10.3389\/fendo.2017.00108<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>2016:<\/p>\n<ul>\n<li>Polyzos A, Holt A, Brown C, Cosme C Wipf P, Gomez Marin A, Castro MR,\u00a0Ayala-Pe\u00f1a S\u00a0and McMurray CT. Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes.\u00a0Hum Mol Genet\u00a0Feb 21 (2016) PMID: 26908614<\/li>\n<li>Pad\u00edn-Irizarry V, Col\u00f3n-Lorenzo EE, Vega-Rodr\u00edguez J, Castro MD, Gonz\u00e1lez-M\u00e9ndez R,\u00a0Ayala-Pe\u00f1a S\u00a0and Serrano, AE. Glutathione-deficient\u00a0Plasmodium berghei\u00a0parasites exhibit growth delay and nuclear DNA damage.\u00a0Free Rad Biol Med\u00a0Mar 4 (2016) PMID: 26952808<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>2015:<\/p>\n<ul>\n<li>Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Pe\u00f1a S and McMurray CT. Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington\u2019s disease. PLOS Genetics. 11(8):e10005267 2015. doi:10.1371. PMID: 26247199<\/li>\n<\/ul>\n<p>2014:<\/p>\n<ul>\n<li>Ayala-Pe\u00f1a, S and Torres-Ramos, CA. Oxidative stress contributes to liver pathology during aging. In: Oxidative Stress and Dietary Antioxidants. Edited by Prof. Victor R. Preedy. Elsevier. 2014.<\/li>\n<li>Rivera-S\u00e1nchez S, McMurray CT, and Ayala-Pe\u00f1a, S. Mitochondrial dysfunction in brain and muscle pathology of Huntington\u2019s disease. In: Systems Biology of Free Radicals and Antioxidants. Edited by I. Laher. Springer-Verlag. 2014<\/li>\n<li>L\u00f3pez-L\u00f3pez L, Nieves-Plaza M, Castro M del R, Font I, Torres-Ramos CA, Vil\u00e1-Perez L and Ayala-Pe\u00f1a, S. Mitochondrial DNA damage is associated with damage accrual and disease duration in patients with Systemic Lupus Erythematosus. Lupus, June 4, 2014 PMID: 24899636<\/li>\n<li>Jansen RJ, Fonseca-Williams S, Bamlet WR, Ayala-Pe\u00f1a S, Oberg AL, Petersen GL and Torres-Ramos CA. Detection of DNA Damage in Peripheral Blood Mononuclear Cells from Pancreatic Cancer Patients. Molecular Carcinogenesis. 2014 Aug 11. Doi: 10.1002\/mc.22189. PMID: 25111947<\/li>\n<li>Escobales N, Nu\u00f1ez RE, Jang S, Parodi-Rullan R, Ayala-Pe\u00f1a S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016\/j.yjmcc.2014.10.009. PMID: 25451170<\/li>\n<\/ul>\n<p>2013:<\/p>\n<ul>\n<li>Ayala-Pe\u00f1a, S. Role of Oxidative DNA Damage in Mitochondrial Dysfunction and Huntington\u2019s Disease Pathogenesis. Free Rad Biol and Med 62:102\u2013110. 2013.<\/li>\n<\/ul>\n<p>2012:<\/p>\n<ul>\n<li>Almas Siddiqui, Sulay Rivera-S\u00e1nchez, Mar\u00eda del R. Castro, Karina Acevedo-Torres, Anand Rane, Carlos A. Torres-Ramos, David G. Nicholls, Julie K. Andersen and Sylvette Ayala-Torres. 2012. Mitochondrial DNA damage is associated with reduced mitochondrial bioenergetics in Huntington\u2019s disease. Free Radical Biology and Medicine Oct 1. 53 (2012) 1478\u20131488. PMID: 22709585<\/li>\n<li>Xun, Z, Sulay Rivera-Sanchez, Ayala-Pe\u00f1a, S, Lim, J, Budworth, H, Skoda, EM, Robbins, PD, Niedernhofer, LJ, Wipf, P and McMurray, CT. Targeting of XJB-5-131 to Mitochondria Suppresses Oxidative DNA Damage and Motor Decline in a Mouse Model of Huntington\u2019s Disease. Cell Reports 2012, Oct 30. PMID: 23122961<\/li>\n<li>Castro, Mar\u00eda del R., Suarez, Edu, Kraiselburd, Edmundo, Isidro, Angel, Paz, Jos\u00e9, Ferder, Le\u00f3n and Ayala-Torres, Sylvette. 2012. Aging increases mitochondrial DNA damage and oxidative stress in liver of rhesus monkeys. Experimental Gerontology 47:29-37.<\/li>\n<\/ul>\n<p>2011:<\/p>\n<ul>\n<li>Kristine S. Vogel, Marissa Perez, Jamila R. Momand, Karina Acevedo-Torres, Kim Hildreth, Rebecca A. Garcia, Carlos A. Torres-Ramos, Sylvette Ayala-Torres, Thomas J. Prihoda, C. Alex McMahan, and Christi A. Walter. 2011. Age-Related Instability in Spermatogenic Cell Nuclear and Mitochondrial DNA Obtained from Apex1 Heterozygous Mice. Molecular Reproduction and Development 8(12): 906-19.<\/li>\n<\/ul>\n<p>2009:<\/p>\n<ul>\n<li>Acevedo-Torres, Berr\u00edos, L., Rosario, N., Dufault, V., Skatchkov, S., Eaton, M.J., Torres-Ramos, C.A., and Ayala-Torres, S. 2009. Mitochondrial DNA damage is a hallmark of chemically-induced and the R6\/2 transgenic model of Huntington\u2019s disease. DNA Repair 8:126-136.<\/li>\n<li>Acevedo-Torres, K., Fonseca, S., Ayala-Torres, S., and Torres-Ramos, C.A. 2009. Requirement of the Saccharomyces cerevisiae APN1 Gene for the Repair of Alkylation and Oxidative Mitochondrial DNA Damage. Environmental &amp; Molecular Mutagenesis 50:317-327.<\/li>\n<\/ul>\n<p>2000:<\/p>\n<ul>\n<li>Ayala-Torres, S., Chen, Y., Svoboda, T., Rosenblatt, J., and Van Houten, B. 2000. Analysis of gene-specific DNA damage and repair using quantitative polymerase chain reaction. In Methods: A Companion to Methods in Enzymology. Doetsch, P. W., Issue Ed., Academic Press, NY. 22, 135-147.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><strong>Additional Publications:<\/strong><\/p>\n<ul>\n<li>Ayala-Torres, S. and Thompson, E. B. 2002. Oxysterol-Induced Apoptosis in Lymphoid Cells. In: Sterols and Oxysterols: Chemistry, Biology, and Pathobiology. Steven J. Fliesler, Volume Editor; Research Signpost, Trivandrum-695 008, India. 159-173.<\/li>\n<li>Johnson, B.H., Rusell, M. J., Krylov, A.S., Medh, R.D., Ayala-Torres, S., Regner, J.L., and Thompson, E.B. 2000. Structure-apoptotic potency evaluations of novel sterols using human leukemic cells. Lipids 35, 305-315.<\/li>\n<li>Ayala-Torres, S., Zhou, F., and Thompson, E.B. 1999. Apoptosis Induced by Oxysterol in CEM Cells is Associated with Negative Regulation of c-Myc. Exp. Cell Res. 246, 193-202.<\/li>\n<li>Thompson, E.B., Medh, R.D., Zhou,, F., Ayala-Torres, S., Ansari, N., Zhang, W., and Johnson, B.H. 1999. Glucocorticoids, oxysterols, and cAMP with glucocorticoids each cause apoptosis of CEM cells and suppress c-myc. J. Steroid Biochem. Molec. Biol. 69, 453-461.<\/li>\n<li>Hodgson, A. V., Ayala-Torres, S., Thompson, E. B., and Liehr, J. G. 1998. Estrogen-induced microsatellite DNA alterations are associated with Syrian hamster kidney tumorigenesis. Carcinogenesis, 19, 2169-2172.<\/li>\n<li>Ayala-Torres, S., Moller, P. C., Johnson, B.H., and Thompson, E.B. 1997. Characteristics of 25-hydroxycholesterol-induced apoptosis in the human leukemic cell line CEM. Exp. Cell Res., 235, 35-47.<\/li>\n<li>Johnson, B.H., Ayala-Torres, S., Chan, L.-N.L., El-Naghy, M., and Thompson, E.B. 1997. Glucocorticoid\/oxysterol-induced DNA lysis in human leukemic cells. J. Steroid Biochem. Molec. Biol., 61, 35-45.<\/li>\n<li>Ayala-Torres, S., Johnson, B. H., and Thompson, E. B. 1994. Oxysterol sensitive and resistant lymphoid cells: correlation with regulation of cellular nucleic acid binding protein mRNA. J. Steroid Biochem. Molec. Biol. 48:307-315.<\/li>\n<li>Thompson, E. B. and Ayala-Torres, S. 1999. Oxysterols and apoptosis: evidence for gene regulation outside the cholesterol pathway. Crit. Rev. Biochem. Mol. Biol. 34, 25-32.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Mitochondrial DNA Damage and Repair, Neurodegeneration and Huntington\u2019s disease, Aging and age-associated metabolic disorders<\/p>\n","protected":false},"featured_media":1460,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[34],"class_list":["post-873","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-34","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team\/873","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/comments?post=873"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/media\/1460"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/media?parent=873"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/pharmacology\/wp-json\/wp\/v2\/dt_team_category?post=873"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}