{"id":863,"date":"2016-03-09T13:48:52","date_gmt":"2016-03-09T13:48:52","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/physiology\/?post_type=dt_team&#038;p=863"},"modified":"2025-10-09T09:23:33","modified_gmt":"2025-10-09T13:23:33","slug":"maria-j-crespo-ph-d","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/maria-j-crespo-ph-d\/","title":{"rendered":"Dr. Maria J. Crespo"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-983569e7df7e8c933\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-983569e7df7e8c933 uvc-4956 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-983569e7df7e8c933 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Maria J. Crespo<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-983569e7df7e8c933 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-315fe5bb52ecd93af5509e2f9577d831.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-315fe5bb52ecd93af5509e2f9577d831.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-315fe5bb52ecd93af5509e2f9577d831 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-315fe5bb52ecd93af5509e2f9577d831 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-315fe5bb52ecd93af5509e2f9577d831 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/dra-crespo.png\" data-srcset=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/dra-crespo.png 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/maria-j-crespo-ph-d\/dra-crespo\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Mar\u00eda J. Crespo\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8326\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8326 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:maria.crespo3@upr.edu\">maria.crespo3@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3285\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3285 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Departments of Physiology\u00a0 and Anesthesiology<\/span><br \/>\n<span style=\"color: #ffffff;\">Associate Director, Hispanic Center of Excellence<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico <\/span><br \/>\n<span style=\"color: #ffffff;\">School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus,\u00a0<\/span><br \/>\n<span style=\"color: #ffffff;\">Office A-667<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR, 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-5074\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-5074 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">\u00a0(787) 758-2525 Ext. 5078<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S. 1981, Chemistry, University of Puerto Rico, Mayaguez, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. 1987, Analytical Chemistry, University of Puerto Rico, Mayaguez, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph.D. 1993, Pharmacology, Univ. of PR, School of Medicine, San Juan, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoc 1995, Vascular Physiology, Univ. of PR, School of Medicine, San Juan, PR<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-798269e7df7e8d667\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-798269e7df7e8d667 uvc-9048  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-798269e7df7e8d667 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PERSONAL STATEMENT<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-798269e7df7e8d667 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">My research goal is to understand the mechanisms underlying endothelial dysfunction and vascular alterations in hypertension, heart failure and diabetes.\u00a0 The contribution of angiotensin II to the genesis of endothelial dysfunction is of particular interest.\u00a0 The presence of a dysfunctional endothelium and alterations in the renin-angiotensin system have been postulated to be involved in the etiology of these complications. Precise mechanisms leading to these alterations, however, are still unknown. In addition, I have extensive experience in training and supervising under-represented minority (URM) students in research. These include undergraduate (over 40 students UPR-Biology), graduate, and post-graduate students (12 MD-students and 10 Postgraduate MDs). I have participated in a significant number of graduate Thesis committees of students from the Physiology Department, and from different departments of the School of Medicine and the University of Puerto Rico main campus.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-53469e7df7e8d6bc\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-53469e7df7e8d6bc uvc-1392  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-53469e7df7e8d6bc h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-53469e7df7e8d6bc .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">My research interests are in the area of cardiovascular Physiology and Pharmacology, especially in pathophysiological conditions such as hypertension, diabetes and congestive heart failure. I am particularly interested in understanding the mechanisms underlying endothelial dysfunction and the vascular modifications present in these conditions. Alterations in the signal transduction pathway of nitric oxide (NO) and in the rennin-angiotensin system (RAS) are studied using animal models of hypertension, heart failure, and diabetes. The principal approaches used in my laboratory include aortic ring contractility studies, determination of cardiovascular variables (cardiac output, blood pressure, and heart rate), and evaluation of NO availability and RAS activity.\u00a0 In addition, we are investigating new pharmacological approaches for the treatment of cerebral vasospasms, particularly in diabetes. For this purpose, we are investigating the effects of dantrolene, either alone or in combination with nimodipine, on blood flow velocity in the middle cerebral artery of a rat model of carotid artery-induced hemorrhagic vasospasms. We found that the combination of these drugs has synergistic effects that decrease vascular contraction, reduce lipid peroxidation, and improve vascular function in diabetic rats after the induction of cerebral vasospasms. \u00a0In summary, we are committed to the development of new adjuvant therapies designed to reduce cardiovascular complications, particularly in the diabetic population.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-180869e7df7e8d6ff\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-180869e7df7e8d6ff uvc-9255  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-180869e7df7e8d6ff h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PAST STUDENTS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-180869e7df7e8d6ff .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Masters\u00a0<\/strong><\/p>\n<p>Nildris Cruz- MS 2007<\/p>\n<p>Jose Quidgey \u2013MS 2005<\/p>\n<p><strong>Doctors of Philosophy \u00a0<\/strong><\/p>\n<p>Marie Roman- PhD 2021<\/p>\n<p>Nildris Cruz- PhD 2014<\/p>\n<p>Jose Quidgley- PhD 2014<\/p>\n<p>Jorge Gonz\u00e1lez-\u00a0 PhD 2004<\/p>\n<p><strong>Postdoctoral Research Fellows from the Anesthesiology Department\u00a0<\/strong><\/p>\n<p>Adri\u00e1n B. Mu\u00f1iz Sarriera, MD, 2023-2024<\/p>\n<p>Cristian A. Rosa Carrasquillo, MD, 2022-2023<\/p>\n<p>Guillermo Tirado, MD, 2021&#8211;2022<\/p>\n<p>Laura Garcia Hernandez, MD, 2018-2019<\/p>\n<p>Jose Manuel Ramirez Franco, MD, 2017-2020<\/p>\n<p>Gabriel Altieri, MD, 2016-2017<\/p>\n<p>Karin\u00e9s Rivera, MD, 2013-2015<\/p>\n<p>Hector Casiano, MD, 2013-2014<\/p>\n<p>Cesar Hernandez, MD, 2012-2013<\/p>\n<p>Osmar Creagh, MD, 2009-2013<\/p>\n<p>Karen Rodriguez MD, 2007-2008<\/p>\n<p>Normidaris Rodriguez, MD, 2007-2008<\/p>\n<p>Jhon Guerra, MD, Fellow, Hematology-Oncology Division, Pediatric Department 2004-2005<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-336669e7df7e8d73f\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-336669e7df7e8d73f uvc-6560  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-336669e7df7e8d73f h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">GRANTS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-336669e7df7e8d73f .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">U.S. Department of Health and Human Services<br \/>\nHispanic Center of Excellence<br \/>\nDates:\u00a0 July 1, 2022 to 2027 D34HP24463-11-00<br \/>\n$3,300,000\/5 years<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-348469e7df7e8d786\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-348469e7df7e8d786 uvc-931  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-348469e7df7e8d786 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-348469e7df7e8d786 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Ram\u00edrez-Rodr\u00edguez \u00c1, Zayas-V\u00e9lez JJ, Dom\u00ednguez D, Carrero E, Crespo MJ. Anesthetic Considerations for and Management of a Parturient With Jarcho-Levin Syndrome: A Case Report of Continuous Spinal Anesthesia for Preterm Cesarean Section. Cureus. 2025 Aug 17;17(8):e90303. doi: 10.7759\/cureus.90303. PMID: 40964570; PMCID: PMC12439861.<\/li>\n<li>Maldonado-Crespo C, Zayas-V\u00e9lez JJ, Col\u00f3n-Rodr\u00edguez E, <strong>Crespo MJ.<\/strong>Successful Anesthetic Management for Laparoscopic Gynecological Surgery in Adult-Onset Alexander&#8217;s Disease: A Case Report. <u><\/u>\u00a02025 May 1;17(5):e83287. doi: 10.7759\/cureus.83287. PMID: 40452725; PMCID: PMC12125702.<\/li>\n<li>Rivera D, Muniz-Sarriera AB, Marcial J, Torres H, Col\u00f3n-Rodr\u00edguez E, <strong>Crespo MJ<\/strong>. Acute Respiratory Failure Secondary to Low-Dose Opioid Administration in a Patient With Obstructive Sleep Apnea and Obesity Hypoventilation Syndrome After Undergoing Trans-sphenoidal Tumor Resection. Cureus. 2024 Mar 26;16(3):e56973. doi: 10.7759\/cureus.56973. PMID: 38665747; PMCID: PMC11045160.<\/li>\n<li>Rojas-Nieves V, Rosa-Carrasquillo C, Reyes-Sullivan A, Rom\u00e1n M, Feliciano-Valls CE, Torres-P\u00e9rez HM, Fern\u00e1ndez P, <strong>Crespo MJ.<\/strong> Case report: A combination of nitroglycerin and adenosine proves effective in repairing a cerebral arteriovenous malformation. Front Neurol. 2023 Aug 23;14:1165155. doi: 10.3389\/fneur.2023.1165155. PMID: 37681010; PMCID: PMC10481525.<\/li>\n<li>Rivera-P\u00e9rez, D., Rosa-Carrasquillo, C., Reyes-Sullivan, A.J., Torres-P\u00e9rez, H., <strong>Crespo, M.J.<\/strong> &#8220;Anesthetic Management Including Postoperative Regional Anesthesia in a Young Adult Patient With Von Willebrand Disease and Osteogenesis Imperfecta.&#8221; Cureus 15, no. 6 (2023).<\/li>\n<li><strong>Crespo MJ,<\/strong> Rom\u00e1n M, Tirado G, Martins AH, Ferrer-Acosta Y Martinez-Jimenez SM. Dantrolene significantly improves cerebral blood flow in a rat model of hemorrhagic vasospasms Pharmacology. 2023 Mar 6:1-9. doi: 10.1159\/000529243. Epub ahead of print. PMID: 36878192.<\/li>\n<li>Rom\u00e1n M, Garc\u00eda L, Morales M,\u00a0<strong>Crespo MJ.<\/strong>\u00a0The combination of dantrolene and nimodipine effectively reduces 5-HT-induced vasospasms in diabetic rats.\u00a0<em><u>Sci Rep.<\/u><\/em>\u00a02021 May 10;11(1):9852. doi: 10.1038\/s41598-021-89338-6. PMID: 33972638; PMCID: PMC8110522.<\/li>\n<li>Rom\u00e1n M, Ram\u00edrez JM, Morales M,\u00a0<strong>Crespo MJ<\/strong>. Significant reduction of vascular reactivity with dantrolene and nimodipine in diabetic rats: a potential approach to cerebral vasospasm management in diabetes.\u00a0<em><u>Pharmacol Rep<\/u><\/em>. 2020;72(1):126-134.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Roman M, Matias J, Morales M, Torres H, Quidgley J. Synergistic effects of Dantrolene and Nimodipine in Reducing PHE-induced Contraction and in Improving ACh-induced Relaxation in the Vasculature of Type-1 Diabetic Rats.\u00a0<em><u>Int J Endocrinol.\u00a0<\/u><\/em>vol. 2018, Article ID 9790303, 2018. doi:10.1155\/2018\/9790303.<\/li>\n<li>Cruz N, Miranda JD,<strong>\u00a0Crespo MJ.<\/strong>\u00a0Modulation of Vascular ACE by Oxidative Stress in Young Syrian Cardiomyopathic Hamsters: Therapeutic Implications.\u00a0<em><u>J Clin Med<\/u>. 2016 Jul 13;5(7). pii: E64. doi: 10.3390\/jcm5070064.<\/em><\/li>\n<li>Gonz\u00e1lez W, Altieri PI, Alvarado E, Banchs HL, Col\u00f3n E, Escobales N,\u00a0<strong>Crespo M<\/strong>. Celiac trunk and branches dissection due to energy drink consumption and heavy resistance exercise: case report and review of literature.\u00a0<em><u>Bol Asoc Med P R<\/u><\/em>. 2015;107(1):38-40.<\/li>\n<li>Altieri PI, Mundo J, Marcial JM, Banch H, Escobales N,\u00a0<strong>Crespo M,\u00a0<\/strong>Gonzalez W<strong>.<\/strong>\u00a0Coronary Levels of Angiotensin II and Endothelin-1 in diabetic Patients with and without Coronary Artery Disease.\u00a0<em><u>J Bol Asoc Med P R<\/u><\/em>. 2015;107(1):5-7.<\/li>\n<li>Altieri PI, Marcial J, Banchs HL, Escobales N,\u00a0<strong>Crespo M<\/strong>. The Metabolic Syndrome in Hispanics \u2013 The Role of Inflammation.\u00a0<em><u>Glob J Obes Diabetes Metab Syndr<\/u><\/em>. 2015;2(1): 012-017.<\/li>\n<li><strong>Crespo MJ,\u00a0<\/strong>Quidgley J. Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats.\u00a0<em><u>World Journal Diabetes<\/u><\/em>. 2015;6(10):1168-78.<\/li>\n<li>Hern\u00e1ndez-Gil de Lamadrid J, Nieves-Rivera JJ, Mora L, Corretjer L, Altieri PI, Su\u00e1rez A, Banchs HL, Mu\u00f1iz J, Soto MI, Escobales N,\u00a0<strong>Crespo M<\/strong>. Metabolic Changes After Roux-N-Y Bariatric Surgery In Hispanics. Bol Asoc Med P R. 2015 ;107(3):66-9. PubMed PMID: 26742199.<\/li>\n<li><strong>Crespo MJ<\/strong>, Cruz N, Quidgley J, Torres H, Hern\u00e1ndez C, Casiano H, Rivera K,.\u00a0 Daily Administration of Atorvastatin and Simvastatin for One Week Improves Cardiac Function in Type 1 Diabetic Rats<em>.\u00a0<u>\u00a0Pharmacology<\/u><\/em>. 2014;93(1-2):84-91.<\/li>\n<li>Quidgley J, Cruz N,<strong>\u00a0Crespo MJ<\/strong>. Atorvastatin Improves Systolic Dysfunction but Does Not Prevent the Development of Dilated Cardiomyopathy in Streptozotocin-induced Diabetic Rats.\u00a0<em><u>Therapeutic Advances in CV Disease<\/u><\/em>\u00a02014;8(4):133-144.<\/li>\n<li>Gonz\u00e1lez W, Altieri PI, Banchs H, Iravedra D, Calder\u00f3n R, , Gonz\u00e1lez- Cancel I, Gurrea\u00a0 C, Nelson Escobales N and\u00a0<strong>Crespo M<\/strong>. HDL as a Biomarker of Rejection in Heart Transplant.\u00a0<em><u>Glob J Obes Diabetes Metab Syndr\u00a0<\/u><\/em>2014;1(1): 101-106.<\/li>\n<li>Bou E, Hernandez P, Cerezo L, Altieri PI, Gurrea C, Figueroa R, Garcia P, Gonzalez-Cancel I, Defendini E, Escobales N,\u00a0<strong>Crespo M,<\/strong>\u00a0Banchs H. Heart tumors in Puerto Rico; De Novo Atrial Fibrillation as Clinical Presentation in a Subgroup of Patients.\u00a0 P R Health Sci J. 2013;32(1):14-17.<\/li>\n<li>Altieri PI, Marcial JM, Banchs H, Escobales N,\u00a0<strong>Crespo M<\/strong>. Ethnicity and genetics are more important than diabetes mellitus and hypertension in producing cardiovascular events in patients with the metabolic syndrome: emphasis in the Puerto Rico population. Bol Asoc Med P R. 2013;105(3):56-63.<\/li>\n<li>Gonz\u00e1lez W, Altieri PI, Alvarado S, Banchs HL, Escobales N,\u00a0<strong>Crespo M<\/strong>, Borges W. Magnesium: the forgotten electrolyte. Bol Asoc Med P R. 2013;105(3):17-20.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Cangiano J, Altieri PI, Escobales N. Aliskiren Improves Left Ventricular Dysfunction and Reduces Cardiac Dilation in Syrian Cardiomyopathic Hamsters.\u00a0<em><u>J Cardiovasc Pharmacol<\/u><\/em>\u00a0 2012;59(6):547-542.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0 Marrero M, Cruz N, Quidgley J, Creagh O, Torres H, Rivera K. Diabetes alters cardiovascular responses to anaesthetic induction agents in STZ-diabetic rats.\u00a0<em><u>Diab Vasc Dis Res<\/u><\/em>. 2011;8(4):299-302.<\/li>\n<li>Altieri PI, Figueroa Y, Banchs HL, de Lamadrid JH, Escobales N,\u00a0<strong>Crespo M<\/strong>. Higher incidence of atrial fibrillation in the metabolic syndrome: a Hispanic population study.\u00a0<em><u>Bol Asoc Med P R<\/u><\/em>. 2011 ;103(4):24-7.<\/li>\n<li>Altieri PI, Figueroa Y, Banch H, Gil de Lamadrid J, Escobales N,\u00a0<strong>Crespo MJ.\u00a0<\/strong>\u00a0Metabolic Syndrome in a Hispanic Population-Cardiovascular Complications.\u201d\u00a0<em><u>QScience Connect<\/u><\/em>\u00a02011;5 doi:10.5339\/connect.2011.5.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Cruz N, Altieri PI, and Escobales N. Chronic Treatment with N-acetylcysteine (NAC) Improves Cardiac Function but Does Not Prevent Progression of Cardiomyopathy in Syrian Cardiomyopathic Hamsters.\u00a0\u00a0<em><u>J Cardiovasc Pharmacol Ther.<\/u><\/em>\u00a0 2011;16(2):197-204.<\/li>\n<li>Marcial JM, Altieri PI, Banch H, Escobales N,\u00a0<strong>Crespo M.\u00a0<\/strong>\u00a0Metabolic Syndrome Among Puerto Ricans and other Hispanic Populations.\u00a0\u00a0<em><u>P R Health Sci J.<\/u><\/em>\u00a02011;30(3):145-151.<\/li>\n<li>Escobales N,\u00a0\u00a0 Ramos JA, Santacana G,\u00a0<strong>\u00a0Crespo MJ.\u00a0<\/strong>Hemodynamic Alterations in the Coronary Circulation of Cardiomyopathic Hamsters: Age and Ang II-dependent mechanisms.\u00a0<em><u>J Card Fail<\/u><\/em><em><u>.<\/u><\/em>\u00a02009;15(10):929-38.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Zalacain J, Dunbar D, Cruz N, and Arocho L. Cardiac Oxidative Stress is elevated at the Onset of Dilated Cardiomyopathy in STZ-diabetic Rats.\u00a0<em><u>J Cardiovasc Pharmacol Ther\u00a0<\/u><\/em>\u00a02008;\u00a0 13(1):64-71.<\/li>\n<li><strong>Crespo MJ<\/strong>, Cruz N, Altieri PI, Escobales N.\u00a0 Enalapril and losartan are more effective than carvedilol in preventing dilated cardiomyopathy in the Syrian cardiomyopathic hamster.\u00a0<em><u>J Cardiovasc Pharmacol Ther.<\/u><\/em>\u00a0 2008;13(3):199-206.<\/li>\n<li>Mundo_Sagardia JA, Figueroa Y, Altieri PI, Banch H, Escobales N,\u00a0<strong>Crespo MJ.\u00a0<\/strong>The atherosclerotic plaque<em>.<\/em><em>\u00a0\u00a0<u>P R Health Sci J.<\/u><\/em>\u00a02008;27(3):241-246.<\/li>\n<li>Escobales N,\u00a0<strong>Crespo MJ.\u00a0<\/strong>Early pathophysiological alterations in experimental cardiomyopathy: The Syrian Cardiomyopathic Hamsters.\u00a0<em><u>P R Health Sci J.<\/u><\/em>\u00a02008;27(4):307-314.<\/li>\n<li>Cruz N, Arocho L, Rosario L,\u00a0<strong>Crespo MJ<\/strong>.\u00a0 Chronic administration of Carvedilol improves cardiac function of 6-month-old Syrian cardiomyopathic hamsters. Pharmacology\u00a0 2007;80:144-150.<\/li>\n<li>Figueroa Y, Altieri PI, Banch H, Hernandez J, Lopez JC, Escobales N,\u00a0<strong>Crespo M.<\/strong>\u00a0Syncope in Puerto Rico.\u00a0 Bol Asoc Med PR 2007;99(3):207-210.<\/li>\n<li>Escobales N,\u00a0<strong>Crespo MJ.<\/strong>\u00a0Angiotensin II-dependent Vascular Alterations in Young Cardiomyopathic Hamsters: Role of Oxidative Stress. Vasc Pharmacol.\u00a0 2006;44(1):22-28.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Quidgley J.\u00a0 Statins decrease serotonin-induced contraction in coronary arteries of swine. Pharmacology\u00a0 2006;76:141-147.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Altieri PI, Escobales N. Increased vascular angiotensin II binding capacity and ET-1 release in young cardiomyopathic hamsters. Vasc Pharmacol. 2006;44(4):247-252.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Quidgley J, Dunbar D. Differential Regulation of Left and Right Coronary Arteries of Swine. Pharmacology 2006;77:137-143.<\/li>\n<li>Figueroa Y, Altieri PI, Banch H, Escobales N,\u00a0<strong>Crespo M<\/strong>,\u00a0 Defendini E, Gonzalez-Cancel I. Coronary Artery Abnormalities in Puerto Rico. P R Health Sci J. 2006;25(3):225-227.<\/li>\n<li>Guerra J, De Jesus A, Santiago-Borrero P,\u00a0 Roman-Franco A, Rodr\u00edguez E,\u00a0<strong>Crespo MJ<\/strong>.\u00a0 Plasma Nitric Oxide Levels Used as an Indicator of Doxorubicin-induced Cardiotoxicity.\u00a0 Hematol J. 2005;5(7):584-8.<\/li>\n<li>Escobales N,\u00a0<strong>Crespo MJ.<\/strong>\u00a0Oxidative-nitrosative Stress in Hypertension. Curr Vasc Pharmacol. 2005;3(3)231-246.<\/li>\n<li>Altieri PI, Banch H, Escobales N,\u00a0<strong>Crespo M<\/strong>, Rodriguez-Orengo J. The Role of Angiotensin Converting Enzyme-inhibitors and Angiotensin II Receptors Blockers in the Management of Arrhythmias and Atrial Fibrillation. Ital Heart J 2004;5(Suppl 1):39S-41S.<\/li>\n<li>Altieri PI, Colon E, Rodriguez-Orengo J, Escobales N, Banch H,\u00a0<strong>Crespo M,\u00a0<\/strong>Figueroa Y. Quantitative analysis of the Vein Drainage to the Right atrium by Cardiovascular Magnetic Resonance in Patients with Chronic and Intermittent Atrial Fibrillation. Ital Heart J 2004;5(Suppl 1):124S-127S.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Moreta S, Gonzalez J. Cardiovascular Deterioration in STZ-diabetic Rats: Possible Role of Vascular RAS.\u00a0\u00a0 Pharmacology 2003;68(1)1-8.<\/li>\n<li>Altieri PI, Escobales N, Rodriguez-Orengo J, Banch H,\u00a0<strong>Crespo M<\/strong>. The Effect of Enalaprilat and Losartan in QT Dispersion. Clinical Cardiac Pacing and Electrophysiology. Monduzzi Editore 2003,\u00a0 pp. 957-961.<\/li>\n<li>Mundo-Sagard\u00eda J, Altieri P, Banch H, Gonz\u00e1lez R, Escobales N,\u00a0<strong>Crespo M,<\/strong>\u00a0Rodr\u00edguez-Orengo J, Cardona F, Torrado J. Role of Endothelin I and Angiotensin II in type 2 diabetics with coronary disease. Bol Asoc Med P R. 2003;95(5):45-50.<\/li>\n<li>Mundo-Sagard\u00eda J, Altieri PI, Banch H, Gonz\u00e1lez R,\u00a0 Escobales N,\u00a0<strong>Crespo M<\/strong>,\u00a0 Rodriguez-Orengo J, Cardona F, Torrado J. La relaci\u00f3n entre los niveles coronarios de endotelina I y de angiotensina II y el di\u00e1metro de vasos coronarios en diab\u00e9ticos tipo 2 con enfermedad coronaria. Rev. Lat. Cardiol. 2003;24(1):24-27<\/li>\n<li>Gonz\u00e1lez-P\u00e9rez J,\u00a0<strong>Crespo MJ<\/strong>. Acute Effects of Toremifene on the Vasculature of Intact and Menopause-induced Rats. Vasc Pharmacol 2003;40(4):205-211.<\/li>\n<li><em>Crespo MJ,<\/em>\u00a0Dunbar DC. Enalapril Improves Vascular and Cardiac Function in STZ-diabetic Rats. Mol Cell Biol\u00a0 2003;49(8) 1311-1318.<\/li>\n<li>Gonz\u00e1lez-P\u00e9rez J,\u00a0<strong>Crespo MJ<\/strong>. Chronic Effects of Selective Estrogen Receptor Modulator Toremifene on the Vasculature of Menopause-induced Rats. Vasc Pharmacol 2003:40(5):261-268.<\/li>\n<li>Altieri PI, Escobales N, Rodriguez-Orengo J,\u00a0<strong>Crespo-Bellido MJ,<\/strong>\u00a0Banch H. El alcohol y las cardiomiopat\u00edas, mecanismos.\u00a0 Rev Lat Cardiol 2002;23(2):66-67.<\/li>\n<li>Altieri PI, Escobales N, Rodriguez-Orengo J,\u00a0<strong>Crespo-Bellido MJ,<\/strong>\u00a0Banch H. El papel del vino tinto en los s\u00edndromes coronarios agudos. Rev Lat Cardiol 2002;23(2):68-69.<\/li>\n<li>Altieri-Nieto PI, Escobales-Alicea N, Rodr\u00edguez-Orengo JF, Banchs-Pieretti H,\u00a0<strong>Crespo-Bellido MJ.\u00a0<\/strong>The Effect of Angiotensin II Receptor Blockers and Converting Enzyme Inhibitors in QT Dispersion. Giornale Italiano di Aritmologia e Cardiostimolazione 2002; 5(S1):129-130.<\/li>\n<li><strong>Crespo MJ<\/strong>, WC de Mello. Chronic Administration of Losartan plus Hydrochlorothiazide Improves Vascular Status in Young Cardiomyopathic Hamsters. Eur J Pharmacol 2001;420 (2-3):133-141.<\/li>\n<li><strong>Crespo MJ<\/strong>. Interaction between AT-1 and Alpha-1 Adrenergic Receptors in Cardiomyopathic Hamsters. J\u00a0 Cardiac Failure 2000;6(3):257-263.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Altieri PI, Escobales N.\u00a0 Vastatins Compete with Norepinephrine for the Alpha-1 Receptor in Rat Aorta. Proceedings of the XXI Congress of European Society of Cardiology Monduzzi Editore, Italy-MediMond, USA, 1999. pp. 243-250.<\/li>\n<li><strong>Crespo MJ<\/strong>\u00a0. Vascular Alterations\u00a0 During the Development and Progression of Experimental Heart Failure.\u00a0\u00a0 J\u00a0 Cardiac Failure 1999;5(1):55-63.<\/li>\n<li>De Mello WC,\u00a0<strong>Crespo MJ.<\/strong>\u00a0\u00a0 Correlation between Changes in Morphology, Electrical Properties, and Angiotensin converting Enzyme Activity in the Failing Heart. Eur J Pharmacol 1999;378(2):187 94.<\/li>\n<li>Altieri PI,\u00a0<strong>Crespo MJ<\/strong>, Escobales N, Rodriguez JF, Banch H.\u00a0 The\u00a0 antiarrhythmic properties of angiotensin converting enzyme inhibitors and angiotensin II blockers. G Ital Cardiol 1999;29(Suppl 5)442-444 .<\/li>\n<li>Altieri PI, Gonz\u00e1lez R, Escobales N,\u00a0<strong>Crespo MJ,<\/strong>\u00a0Banch H.\u00a0 Myocardial Remodeling in Hypertensive Patients. The Role of Converting Enzyme Inhibitions and Angiotensin II Receptor Blockers in Reducing Ventricular Arrhythmia. G Ital Cardiol 1998;28(1)353-356.<\/li>\n<li>Altieri PI, Gonz\u00e1lez , Escobales N,\u00a0 Gonz\u00e1lez R, Banch H,\u00a0\u00a0<strong>Crespo MJ.<\/strong>\u00a0 Lower Incidence of Coronary disease in Puerto Rico (USA Island) than in the Continental USA: a Possible Protective Effect of a Lower LDL\/HDL Lipoprotein Ratio. Proceedings of the XIII World Congress of Cardiology Monduzzi Editore- 1998, pp. 13-16.<\/li>\n<li><strong>Crespo MJ,<\/strong>\u00a0Escobales N, Altieri PI.\u00a0 Altered Vascular Function in Early Stages of Heart Failure in Hamsters.\u00a0 J\u00a0 Cardiac Failure\u00a0 1997;3 (4)311-318.<\/li>\n<li>Altieri PI, Gonz\u00e1lez R, Escobales N,\u00a0<strong>Crespo MJ,<\/strong>\u00a0Banch H. Remodelado Miocardico y Vascular en los Pacientes Hipertensos. Papel de los Inhibidores de la Enzyma Convertidora y de los Bloqueadores de los Receptores de Angiotensina II. Rev Lat Cardiol 1997;18:55-60<\/li>\n<li>Escobales N,\u00a0<strong>Crespo MJ<\/strong>, Altieri PI, Furilla R.\u00a0 Inhibition of Smooth Muscle Cell Calcium Mobilization and Aortic Ring Contraction by Lactone Vastatins.\u00a0\u00a0<em><u>J Hypertens<\/u>\u00a0<\/em>1996;14(1):115-121.<\/li>\n<li><strong>Crespo MJ<\/strong>, Escobales N, Rodriguez\u2011Sargent C. Endothelial Dysfunction in the San Juan Hypertensive Rat; Possible Role of Nitric Oxide Synthase.\u00a0\u00a0<em><u>J Cardiovasc Pharmacol<\/u>.<\/em>\u00a01996;27(6) 802-808.<\/li>\n<li>De Mello WC,\u00a0<strong>Crespo MJ.<\/strong>\u00a0Cardiac Refractoriness in the Rat Is Reduced by Angiotensin II.<\/li>\n<li><em><u>J Cardiovasc Pharmacol<\/u><\/em>\u00a01995; 25(1):51\u201156.<\/li>\n<li>De Mello WC,\u00a0<strong>Crespo MJ,<\/strong>\u00a0Altieri PI. Effect of Enalapril on Intracellular Resistance and Conduction Velocity in Rat Ventricular Muscle.\u00a0<em><u>J Cardiovasc Pharmacol<\/u><\/em><em>.<\/em>\u00a0 1993;22: 259\u2011263.<\/li>\n<li>Altieri PI, De Mello W, Escobales N, Gonzales R,\u00a0<strong>Crespo MJ.<\/strong>\u00a0Enalapril in Congestive Heart Failure and Arrhythmias.\u00a0<em><u>New Trends in Arrhythmias<\/u><\/em>\u00a01992;7(4):1031\u20111042.<\/li>\n<li>De Mello WC,\u00a0<strong>Crespo MJ,\u00a0<\/strong>Altieri PI. Enalapril Increases Cardiac Refractoriness.\u00a0<em><u>J Cardiovasc\u00a0 Pharmacol<\/u><\/em>\u00a0\u00a01992;20:820\u2011825.<\/li>\n<li>Vega CA,\u00a0<strong>Crespo MJ.<\/strong>\u00a0 Dissociation Constants of Primary Phosphate Ion for pH Control in 20 and 50 wt% 1\u2011propanol plus water solvents from 37 to 10 C.\u00a0\u00a0<em><u>J Chem Eng Data<\/u><\/em>\u00a01990; 35(4): 404\u2011406.<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1554,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-863","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team\/863","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/comments?post=863"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media\/1554"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media?parent=863"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team_category?post=863"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}