{"id":864,"date":"2016-03-09T13:50:41","date_gmt":"2016-03-09T13:50:41","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/physiology\/?post_type=dt_team&#038;p=864"},"modified":"2022-02-10T11:22:28","modified_gmt":"2022-02-10T15:22:28","slug":"dr-nelson-escobales","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/dr-nelson-escobales\/","title":{"rendered":"Dr. Nelson Escobales"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-967569e7df7dcf0c6\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-967569e7df7dcf0c6 uvc-7609 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-967569e7df7dcf0c6 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Nelson Escobales<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-967569e7df7dcf0c6 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Professor<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-f8b0b745341658d3532ba73c39e941b2.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-f8b0b745341658d3532ba73c39e941b2.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-f8b0b745341658d3532ba73c39e941b2 .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-f8b0b745341658d3532ba73c39e941b2 .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-f8b0b745341658d3532ba73c39e941b2 alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/Nelson-Escobales.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/Nelson-Escobales.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/dr-nelson-escobales\/nelson-escobales\/\" style=\"--ratio: 300 \/ 300;\" alt=\"\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2687\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2687 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:nelson.escobales@upr.edu\">nelson.escobales@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3203\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3203 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Office\/Laboratory number: A-680, A-663<strong><span class=\"Apple-converted-space\">\u00a0<\/span><\/strong><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-6301\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-6301 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">787-758-2525, ext. 1612<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S. 1977, Biology, University of Puerto Rico, Mayaguez, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. 1977, Biology, University of Puerto Rico, Mayaguez, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph.D. 1982, Physiology, Univ. of PR, School of Medicine, San Juan, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoc 1984, Physiology, Harvard Medical School, Boston, MA<\/span><\/li>\n<\/ul>\n<\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-280169e7df7dcfef6\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-280169e7df7dcfef6 uvc-6154  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-280169e7df7dcfef6 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-280169e7df7dcfef6 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Membrane transport of ions and organic solutes, cardiovascular physiology and pathophysiology, the renin-angiotensin-system.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-479769e7df7dcff46\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-479769e7df7dcff46 uvc-9259  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-479769e7df7dcff46 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Laboratory Members<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-479769e7df7dcff46 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Miriam Castro, Research Specialist<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-170869e7df7dcff8a\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-170869e7df7dcff8a uvc-7805  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-170869e7df7dcff8a h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-170869e7df7dcff8a .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Mitochondrial angiotensin receptors and cardioprotective pathways.<br \/>\nEscobales N, Nu\u00f1ez RE, Javadov S. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1426-H1438. doi: 10.1152\/ajpheart.00772.2018. Epub 2019 Apr 12.<br \/>\nPMID: 30978131 Review.<\/li>\n<li>Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts. Nu\u00f1ez RE, Javadov S, Escobales N. Pflugers Arch. 2018 Sep;470(9):1391-1403. doi: 10.1007\/s00424-018-2153-9. Epub 2018 May 10. PMID: 29748710<\/li>\n<li>Angiotensin II-preconditioning is associated with increased PKC\u03b5\/PKC\u03b4 ratio and prosurvival kinases in mitochondria. Nu\u00f1ez RE, Javadov S, Escobales N. Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1201-1212. doi: 10.1111\/1440-1681.12816. Epub 2017 Sep 20. PMID: 28707739<\/li>\n<li>The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion. Javadov S, Escobales N. J Pharm Pharm Sci. 2015;18(3):547-50. doi: 10.18433\/j3nw2k. PMID: 26517140<\/li>\n<li>Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Escobales N, Nu\u00f1ez RE, Jang S, Parodi-Rullan R, Ayala-Pe\u00f1a S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016\/j.yjmcc.2014.10.009. Epub 2014 Oct 23. PMID: 25451170<\/li>\n<li>Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. Nu\u00f1ez RE, Castro M, Javadov S, Escobales N. J Cardiovasc Pharmacol. 2014 Aug;64(2):172-9. doi: 10.1097\/FJC.0000000000000103. PMID: 24705171<\/li>\n<li>Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster. Escobales N, Crespo MJ. P R Health Sci J. 2008 Dec;27(4):307-14. PMID: 19069355 Review.<\/li>\n<li>Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress. Escobales N, Crespo MJ. Vascul Pharmacol. 2006 Jan;44(1):22-8. doi: 10.1016\/j.vph.2005.09.008. Epub 2005 Nov 21.<br \/>\nPMID: 16301003<\/li>\n<li>Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells.<br \/>\nEscobales N, Castro M, Altieri PI, Sanabria P. J Cardiovasc Pharmacol. 1996 Mar;27(3):383-91. doi: 10.1097\/00005344-199603000-00011. PMID: 8907800<\/li>\n<li>The Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension. Canessa M, Brugnara C, Escobales N. Hypertension. 1987 Nov;10(5 Pt 2):I4-10. doi: 10.1161\/01.hyp.10.5_pt_2.i4. PMID: 2824364 Review.<\/li>\n<li>\u00a0Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Escobales N, Rivera-Correa M, Altieri PI, Rodriguez JF. Amino Acids. 2000;19(2):451-68. doi: 10.1007\/s007260070023.<br \/>\nPMID: 11128552<\/li>\n<li>Amiloride-sensitive Na+ transport in human red cells: evidence for a Na\/H exchange system. Escobales N, Canessa M.J Membr Biol. 1986;90(1):21-8. doi:10.1007\/BF01869682. PMID: 3009823<\/li>\n<li>Osmotic activation of Na(+)-H+ exchange in human endothelial cells. Escobales N, Longo E, Cragoe EJ Jr, Danthuluri NR, Brock TA.Am J Physiol. 1990 Oct;259(4 Pt 1):C640-6. doi: 10.1152\/ajpcell.1990.259.4.C640. PMID: 2171349<\/li>\n<li>Na+ for H+ exchange in rabbit erythrocytes. Escobales N, Rivera A. J Cell Physiol. 1987 Jul;132(1):73-80. doi: 10.1002\/jcp.1041320110. PMID: 3036894<\/li>\n<li>Ca2+-activated Na+ fluxes in human red cells. Amiloride sensitivity. Escobales N, Canessa M. J Biol Chem. 1985 Oct 5;260(22):11914-23. PMID: 3930487<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1378,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-864","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team\/864","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/comments?post=864"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media\/1378"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media?parent=864"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team_category?post=864"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}