{"id":867,"date":"2016-03-09T13:53:54","date_gmt":"2016-03-09T13:53:54","guid":{"rendered":"http:\/\/md.rcm.upr.edu\/physiology\/?post_type=dt_team&#038;p=867"},"modified":"2026-01-27T09:38:31","modified_gmt":"2026-01-27T13:38:31","slug":"dr-jorge-d-miranda","status":"publish","type":"dt_team","link":"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/dr-jorge-d-miranda\/","title":{"rendered":"Dr. Jorge D. Miranda"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column]<div id=\"ultimate-heading-341469e7e3b634372\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-341469e7e3b634372 uvc-1226 accent-subtitle-color\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-341469e7e3b634372 h2'  data-responsive-json-new='{\"font-size\":\"desktop:30px;mobile_landscape:34px;\",\"line-height\":\"desktop:40px;mobile_landscape:44px;\"}' ><h2 style=\"font-weight:bold;color:#0a0a0a;margin-bottom:10px;\">Dr. Jorge D. Miranda<\/h2><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-341469e7e3b634372 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"desktop:18px;mobile_landscape:20px;\",\"line-height\":\"desktop:34px;mobile_landscape:30px;\"}'  style=\"font-weight:bold;margin-bottom:30px;\">Interim Chair<\/div><\/div>[\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;]<div class=\"ult-content-box-container \" >\t\t<div class=\"ult-content-box\" style=\"background-color:#545454;box-shadow: px px px px none;border-style:solid;border-width:5px;border-radius:5px;border-color:#545454;padding:10px;-webkit-transition: all 700ms ease;-moz-transition: all 700ms ease;-ms-transition: all 700ms ease;-o-transition: all 700ms ease;transition: all 700ms ease;\"  data-hover_box_shadow=\"none\"     data-bg=\"#545454\"  data-border_color=\"#545454\" ><style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">.shortcode-single-image-wrap.shortcode-single-image-33c1267a524b440142da8813e6710eef.enable-bg-rollover .rollover i,\n.shortcode-single-image-wrap.shortcode-single-image-33c1267a524b440142da8813e6710eef.enable-bg-rollover .rollover-video i {\n  background: -webkit-linear-gradient();\n  background: linear-gradient();\n}\n.shortcode-single-image-wrap.shortcode-single-image-33c1267a524b440142da8813e6710eef .rollover-icon {\n  font-size: 32px;\n  color: #ffffff;\n  min-width: 44px;\n  min-height: 44px;\n  line-height: 44px;\n  border-radius: 100px;\n  border-style: solid;\n  border-width: 0px;\n}\n.dt-icon-bg-on.shortcode-single-image-wrap.shortcode-single-image-33c1267a524b440142da8813e6710eef .rollover-icon {\n  background: rgba(255,255,255,0.3);\n  box-shadow: none;\n}<\/style><div class=\"shortcode-single-image-wrap shortcode-single-image-33c1267a524b440142da8813e6710eef alignnone  enable-bg-rollover dt-icon-bg-off\" style=\"margin-top:0px; margin-bottom:0px; margin-left:0px; margin-right:0px; width:300px;\"><div class=\"shortcode-single-image\"><div class=\"fancy-media-wrap  layzr-bg\" style=\"\"><img fetchpriority=\"high\" decoding=\"async\" class=\"preload-me lazy-load aspect\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D&#39;http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg&#39;%20viewBox%3D&#39;0%200%20300%20300&#39;%2F%3E\" data-src=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/dr-miranda.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2016\/03\/dr-miranda.jpg 300w\" loading=\"eager\" sizes=\"(max-width: 300px) 100vw, 300px\" width=\"300\" height=\"300\"  data-dt-location=\"https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/dr-jorge-d-miranda\/dr-miranda\/\" style=\"--ratio: 300 \/ 300;\" alt=\"Dr. Jorge D. Miranda\" \/><\/div><\/div><\/div>[vc_empty_space][vc_column_text]<span style=\"color: #ffffff;\"><strong>Contact Info<\/strong><\/span>[\/vc_column_text]<div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-8828\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-mail-03\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-8828 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"mailto:jorge.miranda3@upr.edu\">jorge.miranda3@upr.edu<\/a><\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-2080\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-map-05\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-2080 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">Lab. A-682<\/span><\/p>\n<p><span style=\"color: #ffffff;\">School of Medicine<\/span><br \/>\n<span style=\"color: #ffffff;\">University of Puerto Rico<\/span><br \/>\n<span style=\"color: #ffffff;\">Medical Sciences Campus<\/span><br \/>\n<span style=\"color: #ffffff;\">P.O. Box 365067<\/span><br \/>\n<span style=\"color: #ffffff;\">San Juan, PR 00936-5067<\/span><\/span><\/div><\/li><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-9011\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"icomoon-the7-font-the7-phone-071\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-9011 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\">(787)758-2525 ext. 1631, 1615<\/span><\/span><\/div><\/li><\/ul><\/div>[vc_column_text]<span style=\"color: #ffffff;\"><strong>Education<\/strong><\/span>[\/vc_column_text]<div class=\"standard-arrow list-divider bullet-top\"><ul>\n<li><span style=\"color: #ffffff;\">B.S. 1988, Biology (Cellular), University of Puerto Rico, Rio Piedras, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">M.S. 1990, Biology (Cellular), University of Puerto Rico, Rio Piedras, PR<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Ph.D. 1996, Neuroscience, Baylor College of Medicine Houston, TX<\/span><\/li>\n<li><span style=\"color: #ffffff;\">Postdoc 1996-1998, Spinal Cord Injury &amp; Neuroprotection, University of Miami, School of Medicine \u201cMiami Project to Cure Paralysis\u201d<\/span><\/li>\n<\/ul>\n<\/div><div class=\"uavc-list-icon uavc-list-icon-wrapper ult-adjust-bottom-margin   \"><ul class=\"uavc-list\"><li><div class=\"uavc-list-content\" id=\"list-icon-wrap-3709\">\n<div class=\"uavc-list-icon  \" data-animation=\"\" data-animation-delay=\"03\" style=\"margin-right:5px;\"><div class=\"ult-just-icon-wrapper  \"><div class=\"align-icon\" style=\"text-align:center;\">\n<div class=\"aio-icon none \"  style=\"color:#ffffff;font-size:32px;display:inline-block;\">\n\t<i class=\"fas fa-book\"><\/i>\n<\/div><\/div><\/div>\n<\/div><span  data-ultimate-target='#list-icon-wrap-3709 .uavc-list-desc'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  class=\"uavc-list-desc ult-responsive\" style=\"\"><span style=\"color: #ffffff;\"><a style=\"color: #ffffff;\" href=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2023\/11\/miranda-CV-2023.pdf\">CV<\/a>, <a style=\"color: #ffffff;\" href=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2023\/11\/miranda-biosketch-2023.pdf\">BIOGRAPHICAL SKETCH<\/a><\/span><\/span><\/div><\/li><\/ul><\/div>\t\t<\/div><\/div>[\/vc_column][vc_column width=&#8221;3\/4&#8243;]<div id=\"ultimate-heading-78969e7e3b6352f1\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-78969e7e3b6352f1 uvc-8557  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-78969e7e3b6352f1 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">RESEARCH INTEREST<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-78969e7e3b6352f1 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\">Our research interest is in the area of cell survival and nerve regeneration after trauma to the central nervous system. Spinal cord injury (SCI) results in a series of time-dependent changes at the lesion site, producing a non-permissive or repulsive environment for cell survival and axonal outgrowth. Among the molecular and cellular events triggered by the physical injury to the spinal cord are: necrosis, blood vessel damage, formation of free radicals, edema, infiltration of cells from the immune system, inflammation, axotomy, demyelination, apoptosis and gliosis. The end result from these events is the reduction in sensory and locomotor activity. Therefore, a multi-active compound is necessary to target most of the detrimental events initiated by the injury. We are studying the effects of estradiol or tamoxifen, as neuroprotective agents, to improve functional locomotor recovery after SCI.<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-205569e7e3b635345\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-205569e7e3b635345 uvc-3365  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-205569e7e3b635345 h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">Laboratory of Neuroprotection<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-205569e7e3b635345 .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<p align=\"left\">The focus of this laboratory is to determine the mechanisms of action initiated by Tamoxifen to improve locomotor recovery and increase in white matter spare tissue after SCI.\u00a0 We analyze the expression profile of estrogen receptors and proteins associated to the apoptotic, gliotic, oxidative, inflammatory and regenerative reaction after tamoxifen exposure and if there is any sex differences in their response.\u00a0 In addition, we analyze temporal and spatial protein expression of molecular signals with repellent properties that block axonal regeneration. These signals may be up-regulated after spinal cord trauma inhibiting axonal elongation and synapse formation. To study these events, adult male and female rats are moderately injured at the T10 level using the NYU\/MASCIS impactor device. Defining the specific temporal and spatial expression of individual inhibitory molecules, both on the regenerating fibers and in the local microenvironment, may lead to novel therapeutic strategies to enhanced regeneration and functional recovery after SCI. Then the animals are studied at several levels:<\/p>\n<table border=\"0\" width=\"100%\" cellspacing=\"5\" cellpadding=\"5\">\n<tbody>\n<tr>\n<td align=\"center\"><span class=\"style2\"><strong>Molecular<\/strong><\/span><\/td>\n<td align=\"center\"><span class=\"style2\"><strong>Cellular<\/strong><\/span><\/td>\n<td align=\"center\"><span class=\"style2\"><strong>Anatomic<\/strong><\/span><\/td>\n<td align=\"center\"><span class=\"style2\"><strong>Physiologic<\/strong><\/span><\/td>\n<td align=\"center\"><span class=\"style2\"><strong>Behavioral<\/strong><\/span><\/td>\n<\/tr>\n<tr>\n<td colspan=\"5\" align=\"center\">\n<p align=\"center\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-48 lazy loaded\" src=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda.jpg\" alt=\"labmiranda\" width=\"613\" height=\"230\" data-src=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda.jpg\" data-srcset=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda.jpg 613w, https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda-300x112.jpg 300w, https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda-100x37.jpg 100w\" data-sizes=\"(max-width: 613px) 100vw, 613px\" data-was-processed=\"true\" srcset=\"https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda.jpg 613w, https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda-300x112.jpg 300w, https:\/\/md.rcm.upr.edu\/physiology\/wp-content\/uploads\/sites\/20\/2014\/07\/labmiranda-100x37.jpg 100w\" sizes=\"auto, (max-width: 613px) 100vw, 613px\" \/><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<p><strong>Scientific Collaborators<\/strong><\/p>\n<p>Dr. Jose Santiago, UPR-Carolina<br \/>\n<a href=\"https:\/\/www.uprc.edu\/investigacion-ciencias-naturales\/\">https:\/\/www.uprc.edu\/investigacion-ciencias-naturales\/<\/a><\/p>\n<p>Dr. Iris Salgado, UCC<br \/>\n<a href=\"https:\/\/nam02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fwww.uccaribe.edu%2Fresearch10%2Fresearchers%2Fresearchers-virology%2Firis-salgado%2F&amp;data=05%7C01%7Cdaniel.mora2%40upr.edu%7C80135d7529eb41430b7508db263f8362%7C0dfa5dc0036f461599e494af822f2b84%7C0%7C0%7C638145826442445191%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=aNPsfZmFNZI7hCifJ75VH%2FUtscMoWugLlsiBzU%2BDXyM%3D&amp;reserved=0\" data-auth=\"NotApplicable\">https:\/\/www.uccaribe.edu\/research10\/researchers\/researchers-virology\/iris-salgado\/<\/a><\/p>\n<p>Dr. Walter Frontera, UPR-MSC<br \/>\n<a href=\"https:\/\/nam02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fmd.rcm.upr.edu%2Fphysiology%2Fdt_team%2Fdr-walter-frontera%2F&amp;data=05%7C01%7Cdaniel.mora2%40upr.edu%7C80135d7529eb41430b7508db263f8362%7C0dfa5dc0036f461599e494af822f2b84%7C0%7C0%7C638145826442445191%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=fOEJNSiMVfr%2FReCZgeCW%2F2KcutpVq4dOeQwz8HbamvM%3D&amp;reserved=0\" data-auth=\"NotApplicable\">https:\/\/md.rcm.upr.edu\/physiology\/dt_team\/dr-walter-frontera\/<\/a><\/p>\n<p>Dr. Nataliya Chorna, UPR-MSC<br \/>\n<a href=\"https:\/\/nam02.safelinks.protection.outlook.com\/?url=https%3A%2F%2Fmd.rcm.upr.edu%2Fbiochemistry%2Fdt_team%2Fdr-nataliya-chorna%2F&amp;data=05%7C01%7Cdaniel.mora2%40upr.edu%7C80135d7529eb41430b7508db263f8362%7C0dfa5dc0036f461599e494af822f2b84%7C0%7C0%7C638145826442445191%7CUnknown%7CTWFpbGZsb3d8eyJWIjoiMC4wLjAwMDAiLCJQIjoiV2luMzIiLCJBTiI6Ik1haWwiLCJXVCI6Mn0%3D%7C3000%7C%7C%7C&amp;sdata=uRhfzo5MlTUby6HVYjAhglQpFkjm%2B0Gq6ojb43VfOLA%3D&amp;reserved=0\" data-auth=\"NotApplicable\">https:\/\/md.rcm.upr.edu\/biochemistry\/dt_team\/dr-nataliya-chorna\/<\/a><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-780569e7e3b63538b\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-780569e7e3b63538b uvc-1465  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-780569e7e3b63538b h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PAST AND PRESENT STUDENTS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-780569e7e3b63538b .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>Past &amp; Present doctoral students in the laboratory:<\/strong><\/p>\n<ul>\n<li>Lillian Cruz Orengo, PhD (2005): now Assistant Professor at UC-Davis<\/li>\n<li>Johnny D. Figueroa, PhD (2005): now Assistant Professor at Loma Linda, CA<\/li>\n<li>Jos\u00e9 M. Santiago, PhD (2011): now Associate Professor at UPR-Carolina Campus<\/li>\n<li>Luz Arocho, PhD (2011): now Clinical Supplies Senior Manager at Deciphera Pharmaceuticals, MA<\/li>\n<li>Ana Rodr\u00edguez, PhD (2011): completed her doctorate in Naturopathy and now is instructor at UCC<\/li>\n<li>Odrick Rosas, PhD (2012): completed his MD from UCC and PM&amp; R residency at UPR-MSC<\/li>\n<li>Laurivette Mosquera, PhD (2012): completed her DMD at UPR-MSC<\/li>\n<li>Jennifer M. Col\u00f3n, PhD (2018): completed her postdoctoral training at NIH and now she is working in a Biopharma<\/li>\n<li>Viviana Gonzalez<\/li>\n<li>Luis H. Pagan Rivera<\/li>\n<\/ul>\n<p><strong>Postdoctoral Fellows trained in the Laboratory<\/strong><\/p>\n<ul>\n<li>Margarita Irizarry-Ram\u00edrez, PhD: 2000-2002<\/li>\n<li>Jos\u00e9 M. Santigao, PhD: 2012-2013<\/li>\n<li>Yaria Arroyo, PhD: 2015-2016<\/li>\n<li>Iris K. Salgado, PhD: 2013-2016<\/li>\n<\/ul>\n<p><\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-980969e7e3b6353cc\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-980969e7e3b6353cc uvc-4983  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-980969e7e3b6353cc h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">GRANTS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-980969e7e3b6353cc .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><strong>SC1<br \/>\n<\/strong><strong>NIH\/NIGMS <\/strong><\/p>\n<p>Dates:\u00a0 04\/01\/2022-03\/31\/2026<br \/>\nTotal Direct Cost:\u00a0 $1M<\/p>\n<p><strong>COBRE\/NIEF<br \/>\n<\/strong><strong>NIH\/NIGMS<\/strong><\/p>\n<p>Dates: 07\/01\/23-06\/30\/28<br \/>\nTotal Direct Cost: $5,269,445<\/p>\n<p><strong>NIH\/NIGMS (T32 G-RISE)<\/strong><\/p>\n<p>Dates: 05\/01\/23-04\/30\/28<br \/>\nTotal Direct Cost: $75,000<\/div><\/div>[vc_empty_space]<div id=\"ultimate-heading-454969e7e3b63540d\" class=\"uvc-heading ult-adjust-bottom-margin ultimate-heading-454969e7e3b63540d uvc-9354  uvc-heading-default-font-sizes\" data-hspacer=\"no_spacer\"  data-halign=\"left\" style=\"text-align:left\"><div class=\"uvc-heading-spacer no_spacer\" style=\"top\"><\/div><div class=\"uvc-main-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-454969e7e3b63540d h3'  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}' ><h3 style=\"font-weight:bold;margin-bottom:30px;\">PUBLICATIONS<\/h3><\/div><div class=\"uvc-sub-heading ult-responsive\"  data-ultimate-target='.uvc-heading.ultimate-heading-454969e7e3b63540d .uvc-sub-heading '  data-responsive-json-new='{\"font-size\":\"\",\"line-height\":\"\"}'  style=\"font-weight:normal;\"><\/p>\n<ul>\n<li>Pagan-Rivera LH, Godoy-Vitorino F, Melendez-Vazquez NM, Ocasio-Rivera SE, Santiago-Gascot ME, Santiago JM, Salgado I, Gonzalez V, Martinez-Guzman O, Caceres-Chacon M, Torrado-Tapias A and <strong><u>Miranda JD<\/u><\/strong>. (2025) The Effect of Cefazolin on the Gut Microbiome of Female Rats After Spinal Cord Injury. Microorganism. 13 (10), p. 2324. Doi: 10.3390\/microorganisms13102324. PMID: 41156784<\/li>\n<li>Pagan-Rivera LH, Ocasio-Rivera SE, Godoy-Vitorino F, <strong><u>Miranda JD<\/u><\/strong>\u00a0(2024) Spinal Cord Injury: pathophysiology, possible treatments and the role of the gut microbiota. Frontiers in Microbiology. 15: 1490855. DOI: 10.3389\/fmicb.2024.1490855.\u00a0 PMID: 39744391<\/li>\n<li>Colon-Mercado JM, Torrado-Tapias AI, Salgado IK, Santiago JM, Rivera SEO, Bracho-Rincon DP, Rivera LHP, Miranda JD (2024) The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury. Neural Regen Res. Doi: 10.4103\/NRR.NRR-D-24-00035, PMID: 39314150<\/li>\n<li>Garc\u00eda S\u00e1nchez\u00a0LM, Col\u00f3n Mercado JM, Torrado Tapias AI, Pad\u00edn D\u00edaz K, <strong>Miranda JD<\/strong>, and Santiago Santana JM (2023)\u00a0The limited effects of estradiol administration immediately after spinal cord injury. PRHSJ (42)1, p.23-28.<\/li>\n<li>Martinez M, Martinez N,\u00a0<strong><u>Miranda JD<\/u><\/strong>, Maldonado HM and Silva WI (2019) Caveolin-1 Regulates P2Y<sub>2<\/sub>\u00a0Receptor Signaling During Mechanical Injury in Human 1321N1 Astrocytoma. Biomolecules. Oct. 18; 9(10). PMID: 31635212<\/li>\n<li>Col\u00f3n JM, Gonz\u00e1lez PA, Cajigas A, Maldonado WI, Torrado AI, Santiago JM, Salgado IK and<strong>\u00a0<u>Miranda JD<\/u><\/strong>\u00a0(2018) Continuous Tamoxifen delivery improves locomotor recovery 6 hours after spinal cord injury by neuronal and glial mechanisms in male rats. Experimental Neurology. 299, p.109-121. PMID: 29037533<\/li>\n<li>Colon JM and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2016) Tamoxifen: an FDA approved drug with neuroprotective effects for spinal cord injury recovery. Neural Regeneration Research. 11(8): 1208-1211. PMID: 27651756<\/li>\n<li>Cruz N,<strong>\u00a0Miranda JD<\/strong>\u00a0and Crespo MJ (2016) Modulation of Vascular ACE by Oxidative Stress in Young Syrian Cardiomyopathic Hamsters: Therapeutic Implications. Journal of Clinical Medicine. 5(7). PMID: 27420103<\/li>\n<li>Martinez NA, Ayala AM, Martinez M, Martinez-Rivera FJ,\u00a0<strong>Miranda JD<\/strong>\u00a0and Silva WI (2016) Caveolin-1 Regulates the P2Y2 Receptor Signaling in Human 1321N1 Astrocytoma Cells. J. Biol Chem. 291 (23): 12208-22. PMID: 27129210.<\/li>\n<li>Col\u00f3n JM, Torrado AI, Cajigas A, Santiago JM, Salgado IK, Arroyo Y and\u00a0<strong>Miranda JD<\/strong>\u00a0(2016) Tamoxifen administration immediately or 24 hours after spinal cord injury improves locomotor recovery and reduces secondary damage in female rats. J. Neurotrauma \u2013 Epub ahead of print; PMID: 26896212.<\/li>\n<li>Figueroa JD, Serrano-Illan M, Licero J, Cordero K,\u00a0<strong>Miranda JD<\/strong>\u00a0and De Leon M. (2016) Expression and roles of the lipid chaperone, FABP5, in the restorative actions mediated by docosahexaenoic acid (DHA) following experimental spinal cord injury. J. Neurotrauma \u2013 Epub ahead of print; PMID: 26715431<\/li>\n<li>Mosquera L, Arocho L, Torrado A, Torres Y,\u00a0<strong>Miranda JD<\/strong>\u00a0and Segarra AC (2015) Comparison of two methods of estradiol replacement: their physiological and behavioral outcomes. J. Vet. Sci. &amp; Technology. 6(6): 276-284. PMID: 26962471; Manuscript ID: NIHMS749972<\/li>\n<li>Salgado IK, Torrado AI, Santiago JM,\u00a0<strong>Miranda JD<\/strong>\u00a0(2015) Tamoxifen and Src kinase inhibitors as neuroprotective\/neuroregenerative drugs after spinal cord injury. Neural Regeneration Research. 10(3): 385-390. PMID: 25878585; PMC4396099<\/li>\n<li>Rosas OR, Torrado AI, Santiago JM, Rodriguez AE, Salgado IK,\u00a0<strong>Miranda JD<\/strong>\u00a0(2014) Long-term treatment with PP2 after spinal cord injury resulted in functional locomotor recovery and increased spared tissue. Neural Regeneration Research. 9 (24): 2164-2173. PMID: 25657738; PMC4316450<\/li>\n<li>Mosquera L, Col\u00f3n JM, Santiago JM, Torrado AI, Melendez M, Segarra AC, Rodriguez-Orengo, JF,\u00a0<strong>Miranda JD<\/strong>\u00a0(2014) Tamoxifen and estradiol improved locomotor function and increased spared tissue in rats after spinal cord injury: their antioxidant effect and role of estrogen receptor alpha. Brain Research. 1561: 11-22. PMID: 24637260; PMC4046634<\/li>\n<li>Santos-Vera B, V\u00e1zquez-Torres R, Marrero HG, Acevedo JM, Arencibia-Albite F, V\u00e9lez-Hern\u00e1ndez ME,\u00a0<strong><u>Miranda JD<\/u><\/strong>, Jim\u00e9nez-Rivera CA. (2013) Cocaine sensitization increases I h current channel subunit 2 (HCN\u2082) protein expression in structures of the mesocorticolimbic system. J Mol Neurosci. 50(1):234-45. PMID: 23203153<\/li>\n<li>Santiago JM, Torrado AI, Arocho LC, Rosas OR, Rodr\u00edguez AE, Toro FK, Salgado IK, Torres YA, Silva WI,\u00a0<strong><u>Miranda JD<\/u><\/strong>. (2013) Expression Profile of Flotillin-2 and Its Pathophysiological Role After Spinal Cord Injury. J. Mol. Neurosci. 49(2): 347-59. PMID: 22878913<\/li>\n<li>Figueroa JD, Cordero K, Baldeosingh K, Torrado AI, Walker RL,\u00a0<strong><u>Miranda JD<\/u><\/strong>, and De Leon M (2011) Docosahexaenoic Acid Pretreatment Confers Protection and Functional Improvements after Acute Spinal Cord Injury in Adult Rats. J Neurotrauma . 29(3), 551-66. PMID: 21970623<\/li>\n<li>Rodriguez-Zayas AE, Torrado AI, Rosas OR, Santiago JM, Figueroa JD and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2011) Blockade of P2 Nucleotide Receptors After Spinal Cord Injury Reduced the Gliotic Response and Spared Tissue. J. Mol. Neurosci. 46(1), 167-176. PMID: 21647706<\/li>\n<li>Arocho LC, Figueroa JD, Torrado AI, Santiago JM, Vera AE and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2011) Expression Profile and Role of EphrinA1 Ligand After Spinal Cord Injury. Cell Mol. Neurobiology. 31(7), 1057-1069. PMID: 21603973<\/li>\n<li>Odrick R, Figueroa JD, Torrado A, Rivera M, Konig-Toro F and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2011) Expression and activation of Ephexin Expression is altered after spinal cord injury. Developmental Neurobiology. 71(7): 595-607. PMID: 20949525<\/li>\n<li>Rodr\u00edguez-Zayas A, Torrado A,\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2010) P2Y2 Receptor Expression is Altered in Rats after Spinal Cord Injury. International J. of Devel. Neurosci. Int. Journal of Developmental Neurosc. 28(6), 413-21. PMID: 20619335<\/li>\n<li>Santiago JM, Rosas O, Torrado AI, Gonz\u00e1lez MM, Kalyan-Masih PO, and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2009) Molecular, Anatomical, Physiological and Behavioral studies of rats treated with Buprenorphine.J. Neurotrauma. 26 (10), 1783-1793. PMID: 19653810<\/li>\n<li>Cruz-Orengo L, Figueroa JD, Torrado A, Puig A, Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2007) Reduction of EphA4 receptor expression after spinal cord injury does not induce axonal regeneration or return of tcMMEP response. Neuroscience Letters. 418(1), 49-54. PMID: 17418490<\/li>\n<li>Willson CA, Foster RD, Onifer SM and Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2006) EphB3 receptor and ligand expression in the adult rat CNS. J. Mol. Histol. 37(8-9), p.369-380. PMID 17103029<\/li>\n<li>Cruz-Orengo L, Vel\u00e1zaquez I, Torrado A, Ortiz C, Hern\u00e1ndez C, Puig A, Segarra A, Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2006) Blocking EphA4 upregulation after spinal cord injury results in enhanced chronic pain. Experimental Neurology. 202, p.421-433. PMID: 16959251<\/li>\n<li>Figueroa JD, Benton R, Willson CA, Vel\u00e1zquez I, Torrado A, Ortiz C, Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2006) Inhibition of EphA7 Upregulation after spinal cord injury reduces Apoptosis and Promotes Locomotor Recovery. J. Neurosc. Res. 84(7), p. 1438-51. PMID: 16983667<\/li>\n<li>Irizarry-Ram\u00edrez M, Willson CA, Cruz L, Figueroa JD, Vel\u00e1zquez I, Jones H, Foster R, Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2005) Upregulation of EphA3 Receptors After Spinal Cord Injry.J. of Neurotrauma 22(8), p.929-935. PMID: 16083359<\/li>\n<li>Silva WI, Maldonado HM, Vel\u00e1zquez G, Rubio-D\u00e1vila M,\u00a0<strong><u>Miranda JD<\/u><\/strong>, Aquino E, Mayol N, Cruz-Torres A and Salgado-Villanueva IK (2005) Caveolin isoforms expression during differentiation of C6 glioma cells. Internat. J. of Develpmental Neuroscience 23, p. 599-612. PMID: 16135403<\/li>\n<li>Willson CA,\u00a0<strong><u>Miranda JD<\/u><\/strong>, Foster RD, Onifer SM and Whittemore SR (2003) Transection of the adult rat spinal cord up-regulates EphB3 receptor and ligand expression. Cell Transplantation 12(3), p. 279-290. PMID: 12797382<\/li>\n<li>Willson CA, Irizarry-Ram\u00edrez M, Gaskins HE, Cruz-Orengo L, Figueroa JD, Whittemore SR and\u00a0<strong><u>Miranda JD<\/u><\/strong>\u00a0(2002) Upregulation of EphA Receptor Expression in the Injured Adult spinal Cord. Cell Transplantation 11(3): p.229-239. PMID: 12075988<\/li>\n<li><strong><u>Miranda JD<\/u><\/strong>, White LA, Willson CA, Marcillo A, Jaggid J and Whittemore SR. (1999) Induction of Eph B3 after spinal cord injury.\u00a0<em>Exp.Neurol<\/em>. 156, p.218. PMID: 10192794<\/li>\n<li><strong><u>Miranda JD<\/u><\/strong>, Sin-Chieh L, D\u00edaz ME and Barnes EM, Jr. (1997)\u00a0 Developmental Expression of Chick GABAA Receptor a1 subunit\u00a0<em>in vivo<\/em>\u00a0and\u00a0<em>in vitro<\/em>.\u00a0<em>Dev. Brain Res<\/em>.99, p<em>.<\/em>176-186. PMID: 9125471<\/li>\n<li><strong><u>Miranda JD<\/u><\/strong>\u00a0and Barnes EM, Jr. (1997) Repression of GABAA Receptor a1 Polypeptide Biosynthesis \u00a0\u00a0\u00a0\u00a0 Requires Chronic Agonist Exposure.\u00a0<em>J. Biol. Chem<\/em>. 272 (26), p.16288-16294. PMID: 9195932<\/li>\n<li>Renaud FL, Chiesa R, De Jes\u00fas JM, Lopez A,\u00a0<strong><u>Miranda JD<\/u>\u00a0<\/strong>and Tomassini N. (1991) Hormones and Signal transduction in Protozoa.\u00a0<em>Comp. Biochem. Physiol<\/em>. 100(1), p. 41-45. PMID: 1682102<\/li>\n<\/ul>\n<p><\/div><\/div>[\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][\/vc_column][\/vc_row][vc_row][vc_column][\/vc_column][\/vc_row][vc_row full_width=&#8221;stretch_row_content&#8221; bg_type=&#8221;bg_color&#8221;][vc_column width=&#8221;1\/4&#8243;][\/vc_column][vc_column width=&#8221;3\/4&#8243;][vc_empty_space][vc_empty_space][vc_empty_space][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n","protected":false},"featured_media":1458,"comment_status":"closed","ping_status":"closed","template":"","dt_team_category":[26],"class_list":["post-867","dt_team","type-dt_team","status-publish","has-post-thumbnail","hentry","dt_team_category-faculty","dt_team_category-26","description-off"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team\/867","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team"}],"about":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/types\/dt_team"}],"replies":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/comments?post=867"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media\/1458"}],"wp:attachment":[{"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/media?parent=867"}],"wp:term":[{"taxonomy":"dt_team_category","embeddable":true,"href":"https:\/\/md.rcm.upr.edu\/physiology\/wp-json\/wp\/v2\/dt_team_category?post=867"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}