Main research interest is centered around the biochemistry of age-related cataracts, specifically including (1) postsynthetic modifications of lens proteins; (2) chemistry and immunochemistry of lens pigments; (3) metabolic interactions of the lens with surrounding ocular fluids and tissues, particularly those involving antioxidants, redox-active metabolites and oxidative stress end-products (ascorbate, proteins, hydrogen peroxide, malondialdehyde, glutathione and other sulfhydryls, etc.); (4) immunogenicity of lens proteins.

Interest in the biochemistry of oxidative stress in the eye led to increasing attention given to human cardiovascular diseases (coronary artery disease, atherosclerosis, cardiac failure) and their underlying biochemical mechanisms, including the metabolism of homocysteine.

For analytical purposes, high performance liquid chromatography (HPLC) has been amply used to accomplish these research objectives. HPLC methods have been developed in the laboratory to support clinical research in human inborn errors of metabolism and hereditary diseases.