Dr. Antonio Martins

Associate Professor
Dr. Antonio Martins

Contact Info

  • antonio.martins@upr.edu
  • Room A-331
    Guillermo Arbona Irizarry Building
    University of Puerto Rico Medical Sciences Campus
    San Juan, PR 00936
  • 787-758-2525, ext. 1304

Education

  • B.S. Ciencias Biológicas Modalidades Médicas, Universidad de Mogi daz Cruzes
  • MS en Biología Molecular, Universidad de Sao Paulo
  • PhD en Biología Molecular, Universidad de Sao Paulo
  • Post Doctorado en Bioquímica y Diferenciación neuronal, Universidad de Sao Paulo

ACADEMIC PROFILES

Google Scjolar: https://scholar.google.com/citations?hl=en&user=Pe3l1SUAAAAJ
Linkedin: https://www.linkedin.com/in/antonio-henrique-martins-neuroprotection/?original_referer=
My Bibliography: https://www.ncbi.nlm.nih.gov/myncbi/antonio.martins.1/bibliography/public/

RESEARCH AREAS

Neuroprotection against stroke and Organophosphate Poisoning

RESEARCH INTEREST

I have a broad background in molecular biology including drug development using SELEX technique and neuroscience with specific training and expertise in cell differentiation.  I have been working the last 8 years almost exclusively in neuroprotection. During this period of time I developed interest in neuroprotection against ischemic stroke and organophosphate poisoning. My group are focusing in developing new drugs that are able to protect the neurons after these two illness.

PUBLICATIONS

  • Ferchmin PA, Andino M, Reyes Salaman R, Alves J, Velez-Roman J, Cuadrado B, Carrasco M, Torres-Rivera W, Segarra A, Martins AH, Lee JE, Eterovic VA. (2014) 4R-cembranoid protects against diisopropylfluorophosphate-mediated neurodegeneration. Neurotoxicology 44:80-90.
  • Torres-Rivera W, Pérez D, Park KY, Carrasco M, Platt MO, Eterović VA, Ferchmin PA, Ulrich H, Martins AH (2013). Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage.
  • Martins AH, Alves JM, Perez D, Carrasco M, Torres-Rivera W, Eterović VA, Ferchmin PA, Ulrich H.  Kinin-B2 receptor mediated neuroprotection after NMDA excitotoxicity is reversed in the presence of kinin-B1 receptor agonists. PLoS One. 2012;7(2) :e30755.
  • Eterović VA, Pérez D, Martins AH, Cuadrado BL, Carrasco M, Ferchmin PA. (2011) A cembranoid protects acute hippocampal slices against paraoxon neurotoxicity.; Toxicol In Vitro 25 (7):1468-74.
  • Nery AA, Resende RR, Martins AH, Trujillo CA, Eterovic VA, Ulrich H (2010). Alpha7 nicotinic acetylcholine receptor expression and activity during neuronal differentiation of PC12 pheochromocytoma cells. The Journal of Molecular Neuroscience. 41:329-339.
  • Oliveira CR, Paredes-Gamero EJ, Barbosa CM, Nascimento FD, Batista EC, Reis FC, Martins AH, Ferreira AT, Carmona AK,Pesquero JB, Tersariol IL, Araújo RC, Bincoletto C (2010). Myelopoiesis modulation by ACE hyperfunction in kinin B(1) receptor knockout mice: Relationship with AcSDKP levels. Chem Biol Interact. 184(3):388-95.
  • Trujillo CA, Schwindt TT, Martins AH, Alves JM, Mello LE, Ulrich H (2009). Novel perspectives of neural stem cell differentiation: from neurotransmitters to therapeutics. Cytometry Part A.;75: 38-53.
  • Martins AH,. Alves JM, Trujillo CA, Schwindt TT, Barnabé GF, Motta FLT, Guimarães AO, Casarini DE, Luiz Mello EA, Pesquero, JB, Ulrich H (2008). Kinin-B2 receptor expression and activity during differentiation of embryonic neurospheres.  Cytometry Part A; 73:361-368.
  • Trujillo CA, Nery AA, Alves JM, Martins AH, Ulrich H (2007) Anti-VEGF aptamer as a therapeutic agent in clinical ophtamalogy trials. Clinical Ophthamology, 1, 393-402.
  • Ulrich H, Trujillo CA, Nery AA, Alves JM, Majumder P, Resende RR, Martins AH. (2006). DNA and RNA aptamers: from tools for basic research towards therapeutic applications. Comb Chem High Throughput Screen.9: 619-632.
  • Trujillo, CA., Nery, AA., Martins, AH., Majumder, P., Gonzalez, FA., Ulrich, H. (2006). Inhibition mechanism of the recombinant rat P2X2 receptor in glial cells by suramin and TNP-ATP.  Biochemistry 62, 224-233.
  • Magdesian, MH., Nery, AA., Martins, AH, Juliano, MA., Juliano Neto, L., Ulrich, H., Ferreira, ST. (2005). Peptide blockers of the inhibition of neuronal nicotinic acetylcholine receptors by Abeta.  Journal of Biological Chemistry 280, 31085-31090.
  • Martins, AH, Resende, RR, Majumder, P, Faria, M, Casarini, DE, Tárnok, A, Colli, W, Pesquero, JB, Ulrich, H. (2005) Neuronal differentiation of P19 embryonal carcinoma cells modulates kinin B2 receptor gene expression and function. Journal of Biological Chemistry 280, 19576-19586.
  • Ulrich, H., Martins, AH, Pesquero, JB. (2004). RNA and DNA aptamers in cytomics analysis. Cytometry 59 A, 220-231.
  • Ulrich, H, Martins, AHB., and Pesquero, JB. (2005). RNA and DNA aptamers in cytomics analysis.  In: Current Protocols in Cytometry, J. Paul Robinson (Managing Editor); Zbigniew Darzynkiewicz;  William Hyun;  Alberto Orfao;  Peter Rabinovitch (eds.), John Wiley & Sons, Inc., Hoboken, New York.
  • Martins AH, Hu J, Xu Z, Mu C, Alvarez P, Ford BD, El Sayed K, Eterovic VA, Ferchmin PA, Hao J.Neuroprotective Activity of (1S,2E,4R,6R,-7E,11E)-2,7,11-cembratriene-4,6-diol (4R) in vitro and in vivo in Rodent Models of Brain Ischemia. Neuroscience.
  • Paraoxon and Pyridostigmine Interfere with Neural Stem Cell Differentiation. Berríos VO, Boukli NM, Rodriguez JW, Negraes PD, Schwindt TT, Trujillo CA, Oliveira SL, Cubano LA, Ferchmin PA, Eterović VA, Ulrich H, Martins AH. Neurochem Res. 2015 [Epub ahead of print]
  • Rivera-Pagán AF, Rivera-Aponte DE, Melnik-Martínez KV, Zayas-Santiago A, Kucheryavykh L, Martins AH, Cubano LA, Skatchkov SN, Eaton MJ.Up-regulation of TREK-2 potassium channels in cultured astrocytes requires de novo protein synthesis: relevance to localization of TREK-2 channels in astrocytes after transient cerebral ischemia.PLoS One. 2015 Apr 17;10(4):e0125195. doi: 10.1371/journal.pone.0125195. eCollection 2015.