Our lab is dedicated to exploring the molecular mechanisms behind neurodegenerative diseases, with a central focus on ribo-proteostasis—the intricate balance between RNA metabolism and protein homeostasis. We investigate how disruptions in RNA metabolism, protein trafficking, and cellular quality control lead to the formation of membrane-less biomolecular condensates, such as stress granules. Of particular interest is understanding how these dynamic, liquid-like stress granules transition into solid, toxic aggregates in diseases like ALS and Alzheimer’s.

Building on this foundation, our lab employs cutting-edge techniques, including 3D organoids for modeling various neurodegenerative diseases and high-throughput techniques such as proteomics, RNA sequencing, single-cell spatial mapping, and RNA structural probing (DMS/SHAPE) to dissect complex gene regulatory cellular mechanisms to uncover the broader implications of these processes in human health. Our lab thus strives to understand the fundamental biology of RNA metabolism and protein homeostasis, while also addressing how dysregulations in these processes can lead to disease pathogenesis thus offering potential biomarkers and therapeutic targets for intervention.

Lab Website– www.bajaj-lab.com