Dr. Susan Corey

Professor Ad-Honorem
Dra. Susan Corey

Contact Info

  • Room A338
    Guillermo Arbona Irizarry Building
    University of Puerto Rico Medical Sciences Campus
    San Juan, PR 00936
  • 787-758-2525 Ext. 1358

Education

• BS, (Zoology), Syracuse University, Syracuse, New York
• Ph.D. (Pharmacology), Dr. Joseph D. Robinson’s laboratory, State University of New York, Upstate Medical Center, Syracuse, New York
• Postdoctoral: Axonal transport, Dr. Bernice Grafstein’s laboratory, Department of Physiology, Cornell University College of Medicine, New York, NY
• Visiting Professor, 2-D gel electrophoresis, Dr. Philip Siekevitz’s laboratory, The Rockefeller University, New York, NY,
• Visiting Professor, 2-D gel electrophoresis, Dr. Gianni Piperno’s laboratory, The Rockefeller University, New York, NY.
• Visiting Professor, Na,K-ATPase isoforms, Dr. Kathleen Sweadner, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

PUBLICATIONS

  • Specht SC, Robinson JD. Stimulation of the (Na,K)‑dependent ATPase by amino acids and phosphatidyl serine: chelation of trace metal inhibitors. Arch. Biochem. Biophys. 1973;154:314‑323.
  • Specht SC, Grafstein B. Accumulation of radioactive protein in mouse cerebral cortex after injection of 3H‑fucose into the eye. Exp. Neurol. 1973;41:705‑722.
  • Grafstein B, Miller JA, Ledeen RW, Haley J, Specht S. Axonal transport of phospholipid in goldfish optic system. Exp. Neurol. 1975;46:261‑281.
  • Specht SC. Axonal transport in the optic system of neonatal and adult hamsters following injection of 3H‑fucose into the eye. Exp. Neurol. 1977;54:352‑368.
  • Specht SC. Transneuronal transfer of radioactive substances during postnatal development of the hamster visual system. Exp. Neurol. 1980; 69:213‑225.
  • Specht SC. Postnatal changes in enzyme activities in synaptosomes isolated from hamster optic nerve endings. J.Neurochem. 1982;39:310‑314.
  • Specht SC. Axonal transport of Na,K‑ATPase in optic nerve of hamster. Current Topics in Membranes and Transport 19. 1983; 819-823.
  • Specht SC, Sweadner KJ. Rapid axonal transport of two molecular forms of Na,K‑ATPase in optic nerve of albino rats. Proc. Nat. Acad. Sci. USA 1984;81,1234-1238.
  • Specht SC. Development and regional distribution of two molecular forms of the catalytic subunit of the Na,K‑ATPase in rat brain. Biochem. Biophys. Res. Comm. 1984;121, 208-212.
  • Specht SC. Postnatal changes in subcellular localization of 3H‑fucosyl glycoproteins axonally transported into hamster optic nerve endings. Neurochem. Res. 1984;9,59-71.
  • Specht SC, Castro S, Vizcarra N. Characteristics of alpha and alpha(+) in rat brain. in The Sodium Pump, The Company of Biologists, Ltd, Cambridge, Edited by I. Glynn and C. Ellory, 1985; pp. 165‑170.
  • Specht SC, Del Valle E, Castro Hernandez S. Increased in vivo synthesis of Na pump isoforms after pre‑treatment with citrate buffer. in The Na,+K+‑Pump, Part B: Cellular Aspects Edited by Skou and Maunsbach, 1988;pp. 143‑147.
  • Specht SC. Molecular isoforms of the sodium in brain. Puerto Rico Health Sciences Journal. 1988;7: 189‑194.
  • Lopez-Rosado and Corey, S (S. Specht). A ouabain-sensitive Na,k-ATPase in the sea anemone Stoichactis helianthus. Preliminary characterization. In The Sodium Pump:Recent Developments. J.H. Kaplan and P. De Weer, editors. The Rockefeller University Press, New York, 1991; 489 -492.
  • Specht S, Martin J, Gaud, E, De Hoyos J. Molecular isoforms of Na/K-ATPase in the nervous system and kidney of the spontaneously diabetic BB/Wor rat. Biochim. Biophys. Acta 1991; 1118:77-82.
  • Corey-Specht S, Lopez-Rosado R, Santos-Berrios C, Figueroa-Nieves R. A ouabain-sensitive Na,K-ATPase in tentacles of the sea anemone Stichodactyla helianthus. Comp. Biochem. Physiol. pt B, 1995;110:555-563.
  • Specht SC, Rodriguez C, Quiñones L, Velazquez S. Effect of High Ionic Strength and Inhibitors of H,K-ATPase on the Ouabain-sensitive K-p-Nitrophenyl Phosphatase Activity in the Sea Anemone Stichodactyla Comp. Biochem. Physiol. pt B, 1997; 117B: 217-224.
  • Corey (Specht) S. Recent developments in the therapeutic potential of cannabinoids. PRHSJ. 2005;24:27-34.
  • Woolcock K,  Specht SC. Modulation of Na, K-ATPase activity by prostaglandin E1 and [D‑Ala2,N‑Me‑Phe4,Gly5-ol]‑enkephalin Life Sciences 2006; Mar 6;78(15):1653-61.
  • Arystarkhova E, Donnet C, Munoz-Matta A, Specht S, Sweadner KJ. Multiplicity of expression of FXYD proteins in mammalian cells: dynamic exchange of phospholemman and gamma subunit in response to stress.Am J Physiol Cell Physiol. 2007; 292 (3): C1179-91.
  • Gonzalez-Tejera GM and Corey S. CYP2D6 Genotypes in Puerto Rican Psychiatry Patients with Intolerance of Antidepressants and Antipsychotics. Bol Assn Med PR. 2009.
  • Gaedigk A, Gonzalez-Tejera G, Corey S. CYP2D6*31 sequence update. CYP2D6 allele nomenclature [database on the Internet]. Human Cytochrome P450 (CYP) Allele Nomenclature Committee [cited 2009 Mar 27]. Available from: http://www.cypalleles.ki.se/cyp2d6.htm.
  • Gaedigk A, García MI, Pearce RE, Sánchez S, García-Solaesa V, Lorenzo-Romo C , Gonzalez-Tejera G, Corey S. Discovery of the non-functional CYP2D6*31 allele in Spanish, Puerto Rican and US Hispanic populations. Eur J Clin Pharmacol. 2010 Sep;66(9):859-64. Epub 2010 May 16.
  • Gonzalez Tejera G, Gaedigk A, Corey S. Genetic variants of the drug-metabolizing enzyme CYP2D6 in Puerto Ricans: Implications for breast cancer patients. Puerto Rico Health Sci J. 2010; 29(3):299-304.
  • Karla Claudio-Campos, Carmelo Orengo-Mercado, Jessicca Y. Renta, Muriel Peguero, Ricardo García, Gabriel Hernández, Susan Corey, Carmen L. Cadilla, and Jorge Duconge Pharmacogenetics of healthy volunteers in Puerto Rico Drug Metabol Personal Ther. 2015 Dec 1; 30(4): 239–249.
  • Vélez-Pastrana S, Campos-Colberg M, González-Sanchez J, George R, Campos-Colberg V,  López B, Susan Corey-Best. Non-Fatal Opioid Overdose and Abuse Visits to a University Hospital Emergency Department in Puerto Rico, 2009-2018. Puerto Rico Health Sci Journal. (June 2022).