Dr. Edna E. Aquino

Associate Professor
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Dr. Edna E. Aquino

EDUCATION

  • Certificate in Bioethics, UPR-MSC, 2008.
  • Post-Doctoral Training, Biochemistry and Physiology of Microdomains, UPR-MSC, 2003.
  • Post-Doctoral Training, Biochemistry of Receptors UPR-RP, 2002.
  • Ph.D. Microbiology and Medical Zoology, UPR-MSC, 2000.
  • Certificate in Medical Technology, UPR-MSC, 1992.
  • B.S. and Pre-Medical, Interamerican University Metropolitan Campus, 1986.

Malaria, caused by Plasmodium spp., remains as the most devastating parasitic disease affecting more than 225 million people worldwide. Nearly 1 million deaths are reported yearly, mostly children under the age of 5. Half of the world’s population is considered at risk of malaria. Despite of ongoing efforts to generate novel antimalarials, find alternate vector controlling strategies and develop of an effective vaccine, the emergence and rapid spread of multidrug resistant Plasmodium coupled to the insecticide-resistant Anopheles strains, has resulted in re-emergence of this disease. There are currently no new drugs available and resistance has been reported for all of the antimalarials currently in use. Our previous and current work focuses in understanding mechanisms of underlying the development of Plasmodium drug resistance. The long-term goal of our research is to fully understand oxidative stress coping mechanisms and the glutathione biosynthetic pathway in the rodent malaria model, P. berghei in order to identify potential targets and drug resistance mechanisms to control the spread of malaria.

RESEARCH INTEREST

  • Epidemiology and molecular mechanisms of antimicrobial resistance in Gram negative bacteria.
  • Characterization of methicillin resistantStaphylococcus aureus(MRSA) isolated from PR.

PUBLICATIONS

  • Martínez T, Vázquez GJ,Aquino EE, Ramirez-Ronda, R, Robledo IE. First Report of aPseudomonas aeruginosaClinical Isolate Co-Harboring KPC-2 and IMP-18 Carbapenemases. Int J Antimicrob Agents.39:542-3,2012.
  • Martínez, T, Vázquez, GJ,Aquino, EE,Goering, RV, Robledo IE. Two novel class I integron arrays encoding IMP-18 metallo-beta-lactamase gene inP. aeruginosaclinical isolates from Puerto Rico. Antimicrob Agents Chemother. 56:2119-21,2012.
  • Robledo, IE, Vázquez, GJ, Moland, ES,Aquino, EE,Goering, RV Thomson, KS, Santé, MI, Hanson, ND. Dissemination and Molecular Epidemiology of KPC-ProducingKlebsiella pneumoniaeCollected in Puerto Rico Medical Center Hospitals during a 1-Year Period. Epidemiology Research International Volume 1155-1163,2011.
  • Robledo IE,Aquino EE,Vazquez GJ. Detection of the KPC gene inEscherichia coli, Klebsiellapneumoniae, Pseudomonas aeruginosa, andAcinetobacter baumanniiduring a PCR-based nosocomial surveillance study in Puerto Rico. Antimicrob Agents Chemother 55(6):2968-2970,2011.
  • Iraida E Robledo,Edna E Aquino, Maria I Santé, Jorge L Santana, Diana M. Otero, Carlos F. León and Guillermo J Vázquez. Detection of KPC inAcinetobacter sp. in Puerto Rico. Antimicrobial Agents and Chemotherapy. 54: 1354-1357, March2010.
  • Wolter D.J., Khalaf N., Robledo I. E., Vázquez G. J., Santé M. I.,Aquino E. E.,Goering R.V., and Hanson N.D. Surveillance of Carbapenem ResistantPseudomonas aeruginosafrom Puerto Rico Medical Center Hospitals: Dissemination of KPC and IMP-18-lactamases. Antimicrobial Agents and Chemotherapy 53: 1660-1664, April2009.
  • Silva W.I., Velázquez G., Rubio-Dávila M., Miranda J.D., Jordán J., Maldonado H.M.,Aquino E.,Mayol N., and Cruz A. Caveolin Isoform Expression During Differentiation of C6 Glioma Cells. Int. J. Devl Neuroscience. 23: 599 – 612, July2005.
  • Flores R.V., Hernández-Pérez M.G.,Aquino E.,Garrad Richard C., Weisman G.A., and González F. Agonist-induced Phosphorylation and Desensitization of the P2Y2 Nucleotide Receptor. Molecular and Cellular Biochemistry. 280: 35 – 45, May2005.
  • Aquino-Piñero E. and N. Rodríguez-del Valle. Characterization of a Protein Kinase C Gene in Sporothrix schenckii and Its Expression during the Yeast to Mycelium Transition. Medical Mycology 40: 185-199,2002.
  • Aquino-Piñero, E.and N. Rodríguez-del Valle. Different Protein Kinase C Isoforms are Present in the Yeast and Mycelium Forms ofSporothrix schenckii.Mycopathologia 138: 109-115,1997.

CONTACT

Dept. of Microbiology and Zoology,
Main Building, 3rd floor (Office B-321 / Lab A-304)
University of Puerto Rico-School of Medicine,
P.O. Box 365067, San Juan, P.R. 00936-5067.
Phone: (787)758-2525 Office ext. 2096, lab ext 1315
Fax: (787) 758-4808

edna.aquino@upr.edu