Jorge, Juan C., PhD

Professor
Dr. Juan C. Jorge

Contact Info

  • juan.jorge@upr.edu
  • Laboratory of Sex and Gender Variance
    International Journal of Sexual Health, Advisory Board
    Medical Sciences Campus
    Dr. Guillermo Arbona Irizarry Bldg.
    Lab A520/A521/A522
  • 787-758-2525 x1506, 1536

Research Interests

Sexual dimorphisms; incidence of congenital malformations affecting genitalia and sex organs; public health epidemiological studies regarding pediatric psychiatric treatment and diagnosis and follow up of pediatric patients with congenital malformations.

Present Funding:

The Alliance / Title V

Selected Publications:

  • Jorge JC, Valerio-Pérez L, Esteban C, Rivera-Lassen AI (2021) Intersex care in the United States and international standards of human rights. Global Public Health May 16(5):679-691 doi: 10.1080/17441692.2019.1706759. PMID: 31874072
  • Piñeyro-Ruiz C, Serrano H, Jorge I, Miranda-Valentin E, Perez-Brayfield MR, Camafeita E, Mesa R, Vázquez J, Jorge JC (2020) A proteomics signatura of mild hipospadias: A pilot study. Front Pediatr Dec 23; 8:586287. doi: 10.3389/fped.2020.586287. eCollection 2020.PMID: 33425810
  • Piñeyro-Ruiz C*, Chorna NE, Perez-Brayfield MR, Jorge JC (2020) Severity-dependent profile of the metabolome in Hypospadias. Front Pediatr Apr 24; 8:202 do1:10.3389/fped.2020.00202. eCollection 2020. PMID: 32391298
  • Piñeyro-Ruiz C*, Serrano H, Pérez-Brayfield MR, Jorge JC (2020) New frontiers on the molecular underpinnings of hypospadias according to severity. Arab J Urology, May 24 2020, https://doi.org/10.1080/2090598X.2020.1760589.
  • Soto-Palou FG, Escudero-Chu K, Piñeyro-Ruiz C*, Jorge JC, Pérez-Brayfield M (2019) Evaluation and management of the undescended testis in Puerto Rico: A single surgeon´s 10 years of experience. PR Health Sci J Dec 2019 38(4):269-271. PMID:31935315
  • Tania Real-Quintanar, Rebeca Robles-García, María Elena Medina-Mora, Juan Carlos Jorge, Lucía Vázquez-Pérez. (2019). Transgender identity and cryptorchidism: Case Study. Salud Mental, 42(1) 51-57.  doi: 10.17711/SM.0185-3325.2019.007
  • Riestra-Candelaria BL*, Rodríguez-Mojica W, Jorge JC (2018) Anatomical criteria to measure the adult right liver lobe by ultrasound. Sonography 64-69 doi:10.1002/sono.12162
  • Riestra-Candelaria BL*, González-Rodríguez LA, Rodriguez-Mojica W, Vázquez-Quiñones LE, Jorge JC (2019) Sonographic Features of the Liver Among Females with Type 2 Diabetes. J Diagn Med Sonogr. 2019 May;35(3):189-197. doi: 10.1177/8756479319834927. Epub 2019 Mar 8. PMID: 31131376
  • Sánchez-Montoya EL, Reyes MA, Pardo J, Nuñez-Alarcón J, Ortiz JG, Jorge JC, Bórquez J, Mocan A, Simirgiotis MJ. (2017) High Resolution UHPLC-MS Metabolomics and Sedative-Anxiolytic Effects of Latua pubiflora: A Mystic Plant used by Mapuche Amerindians. Front Pharmacol. 2017 Jul 26;8:494. doi: 10.3389/fphar.2017.00494. PMID: 28798689
  •  Jorge JC, Pérez-Brayfield MR, Torres CM, Piñeyro-Ruiz C*, Torres N (2016) Age of the mother as a risk factor and timing of hypospadias repair according to severity. SOJ Urol & Nephrol 2:1-5. PMID:27331196
  • Riestra-Candelaria B*, Rodríguez-Mojica W, Vázquez L, Jorge JC (2016) Ultrasound accuracy of liver length measurement with cadaveric specimens. J Diagn Med Sonogr 32:12-19 PMID: 26966729
  • Perez-Brayfield MR, Jorge JC, Aviles LA, Diaz J, Ortiz V, Morales-Cosme W (2016) Concordance of expert and parental opinion about hypospadias surgical outcome is severity dependent. Front Pediatr 4:2. Doi: 10.3389/fped.2016.00002.eCollection 2016 PMID:26835440
  • Jorge JC (2016) El nombrar clínico: la disforia de género. Boletín Diversidad 7 [www.boletindiversidad.org].
  • Avilés LA, Alvelo-Maldonado L, Padró-Mojica I, Seguinot J, Jorge JC (2014) Risk factors, prevalence trend, and clustering of hypospadias cases in Puerto Rico. J Pediatr Urol 10(6):1076-1082.
  •  Jorge JC, Agramonte-Machado A (2013) Standards of care for congenital adrenal hyperplasia: a call for change in the Caribbean region. Sexuality Research and Social Policy 10, 3, 233-241.
  • Jorge, JC (2011) Lecciones médicas sobre la variante sexual: el hermafrodita del siglo XVI y el intersexual del siglo XXI. Cuicuilco, 18 (52), 251-272.
  • Acevedo P, Jorge JC, Cruz-Sánchez A, Amy E, Barreto-Estrada JL. (2011) A ten-year assessment of anabolic steroid misuse among competitive athletes in Puerto Rico. West Indian Med J 60(5):531-535.
  • Jorge JC (2010) The embryology of gender. Journal of LGBT Youth, 7: 310-319. Spanish version: Jorge JC (2010). La embriología del género y modelos moleculares emergentes para explicar la diferenciación sexual. Sexología, 15(2), 37-49.
  • Sánchez Montoya EL, Hernández L, Barreto-Estrada JL, Ortiz JG, Jorge JC. (2010) The testosterone metabolite 3a-diol enhances female rat sexual motivation when infused in the nucleus accumbens shell. J Sex Med 7(11):3598-3609.
  •  Jorge JC, Echeverri C, Medina Y, Acevedo P (2008) Male gender identity in an XX individual with congenital adrenal hyperplasia.  a response by the authors.  Journal of Sexual Medicine, August 29, e-pub ahead.
  • Jorge JC, Echeverri C, Medina Y, Acevedo P (2008) Male gender identity in an XX individual with congenital adrenal hyperplasia.  Journal of Sexual Medicine, 5: 122-131.
  • Jorge JC (2007) Statistical management of ambiguity: bodies that defy the algorithm of sex classification.  DataCrítica: International Journal of Critical Statistics 1 (1): 19-37.   www.datacritica.net
  • Barreto-Estrada JL, Parrilla-Carrero J, Jorge JC (2007) Exposure to an anabolic steroid changes female mice sexual responses according to sex partner.  Journal of Sexual Medicine, 4 (4): 878-885.
  • Rivera-Arce JC, Morales-Crespo L, Vargas-Pinto N, Velázquez KT, Jorge JC (2006)  Central effects of the anabolic steroid 17αmethyltestosterone in female anxiety.  Pharmacology, Biochemistry, and Behavior, 84 (2): 275-281.
  • Pérez-Acevedo NL, Lathroum L, Jorge JC (2006) The neurosteroid 3αDIOL modulates place preference and anxiety when infused in the basolateral amygdala according to sex.  Behavioral Neuroscience, 120 (3): 632-640.
  • Rojas Y, Rivera-Ramos I, Rundle V, Jorge JC (2006) Modulation of elevated plus maze behavior after chronic exposure to the anabolic steroid 17α-methyltestosterone in adult mice.  Hormones and Behavior, 49(1):123-8.
  • Jorge JC, Gonzalez L, Fortis A, and Cruz N (2005) Sex-specific modulation of anxiety and locomotion after neonatal exposure to pregnenolone sulfate.  Physiology and Behavior, 83 (5), 779-786.
  • Jorge JC, Velázquez KT, Ramos DL, Lorenzini I, Marrero J, Maldonado-Vlaar C (2005) A testosterone metabolite is rewarding to ovariectomized female rats.  Behavioral Neuroscience, 119 (5), 1222-1226.
  • Barreto-Estrada J, Barreto J, Fortis-Santiago Y, Rivera-Ramos I, Fortis-Santiago A, Jorge JC (2004) Modulation of affect after chronic exposure to the anabolic steroid 17α-methyltestosterone in adult mice.  Behavioral Neuroscience, 118 (5), 1071- 1079.
  • Jorge JC, McIntyre KL, Henderson LP (2002) The function and the expression of forebrain GABAA receptors expression change with hormonal state in the adult mouse. J. Neurobio. 50: 137-149.
  • Nett ST, Jorge-Rivera JC, Clark AS, Henderson LP (1999) Properties and sex-specific differences in GABAA receptors in neurons expressing g1 subunit mRNA in the preoptic area of the rat. J. Neurophysiol. 81: 192-203.
  • Jorge-Rivera JC, Sen K, Birmingham JT, Abbott LF, Marder E (1998) Temporal dynamics of convergent modulation at a crustacean neuromuscular junction.  J. Neurophysiol. 80: 2559-2570.
  • Jorge-Rivera JC (1998) “Dimorfismo sexual en el cerebro”.   Electronic Journal: http:// www.ciencia.cl/ CienciaAlDia/volumen1/numero2/articulos/articulo4.html
  • Jorge-Rivera JC, Marder, E (1997) Allatostatin decreases stomatogastric neuromuscular transmission in the crab, Cancer borealis.  J.Exp.Biol.  200: 2937-2946.
  • Weimann JM, Skiebe P, Heinzel HG, Soto C, Kopell N, Jorge-Rivera JC, Marder E (1997) Modulation of oscillator interactions in the crab stomatogastric ganglion by crustacean cardioactive peptide. J.Neurosci. 17(5): 1748-1760.
  • Marder E, Jorge-Rivera JC, Kilman V, Weimann JM (1997) Peptidergic modulation of synaptic transmission in a rhythmic motor pattern. In: Synapses (B.Festoff and D.Hantal, eds.)  Advances in Organ Biology, Vol. 2, JAI Press, Inc., Greenwich, Conn., pp. 213-233.
  • Jorge-Rivera JC, Marder E (1996) TNRNFLRFamide and SDRNFLRFamide modulate muscles of the stomatogastric system of the crab Cancer borealis.  J.Comp.Phys.179(6): 741-751.
  • Sen K, Jorge-Rivera JC, Marder E, Abbott LF (1996) Decoding synapses. J.Neurosci. 16(19): 6307-6318.
  • Sen K, Jorge-Rivera JC, Marder E, Abbott LF (1995) Neural decoding and synaptic response prediction. In: Computational Neuroscience: Trends in Research 1995 (J.M.Bower, ed.) Academic Press Inc., San Diego, CA, pp. 131-136.
  • Jorge-Rivera JC (1995) Formación y Transformación de la Identidad Homosexual: Historia de Vida de un Hombre Puertorriqueño. In: Identidade Masculina S.Nolasco, Editor. Rio de Janeiro, Brasil.
  • Jorge-Rivera JC (1992) DSM: Discurso Psicológico Medicalizado. In DSM: aspectos teóricos políticos, y metodológicos. G.Bernal & W.Rodriguez Editors. San Juan, P.R., pp. 36-46.