Abstracts

Papers

  1. Chen YC, Ma NX, Pei ZF, Wu Z, Do-Monte FH, Keefe S, Yellin E, Chen MS, Yin JC, Lee G, Minier-Toribio A, Hu Y, Bai YT, Lee K, Quirk GJ, Chen G. (2019) A NeuroD1 AAV-Based Gene Therapy for Functional Brain Repair after Ischemic Injury through In Vivo Astrocyte-to-Neuron Conversion.  Molecular Therapy (Cell Press) Sep 6, doi: 10.1016/j.ymthe.2019.09.003.

     

  2. Diehl MM, Bravo-Rivera C, Quirk GJ (2019) The study of active avoidance: A platform for discussion.  Neuroscience & Biobehavioral Reviews 107:229-237.

     

  3. Dopfel D, Perez PD, Verbitsky A, Bravo-Rivera H, Ma Y, Quirk GJ, Zhang N. (2019) Individual variability in behavior and functional networks predicts vulnerability using an animal model of PTSD. Nat Commun. 2019 May 30;10(1):2372. doi: 10.1038/s41467-019-09926-z.

     

  4. Quirk GJ. (2019) Neuroscience Research and Mentoring in Puerto Rico: What Succeeds in This Environment? Journal of Neuroscience 30 January 2019, 39 (5) 776-782; DOI: https://doi.org/10.1523/JNEUROSCI.2352-18.2018.

     

  5. Martínez-Rivera FJ, Bravo-Rivera C, Velázquez-Díaz CD, Montesinos-Cartagena M, Quirk GJ. (2018) Prefrontal circuits signaling active avoidance retrieval and extinction. Psychopharmacology (Berl). 2018 Sep 27. doi: 10.1007/s00213-018-5012-7. Epub ahead of print.

     

  6. Rosas-Vidal LE, Lozada-Miranda V, Cantres-Rosario Y, Vega-Medina A, Melendez L, Quirk GJ. (2018) Alteration of BDNF in the medial prefrontal cortex and the ventral hippocampus impairs extinction of avoidance. Neuropsychopharmacology. 2018 Aug 11. doi: 10.1038/s41386-018-0176-8. Epub ahead of print.

     

  7. Diehl MM, Bravo-Rivera C, Rodriguez-Romaguera J, Pagan-Rivera PA, Burgos-Robles A, Roman-Ortiz C, Quirk GJ. (2018) Active avoidance requires inhibitory signaling in the rodent prelimbic prefrontal cortex. Elife 2018 May 31;7. pii: e34657. doi: 10.7554/eLife.34657.

     

  8. Rodriguez-Romaguera J and Quirk GJ (2017) Extinction of conditioned fear and avoidance: Relevance for OCD. In: Obsessive Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment, C. Pittenger, Ed., Oxford University Press.

     

  9. Quirk GJ (2017) Less fear, more diversity.  PLoS Biology 15:e2002079. doi: 10.1371/journal.pbio.2002079.

     

  10. Do Monte F, Minier-Toribio A, Quiñones-Laracuente K, Medina-Colón EM, Quirk GJ (2017) Thalamic regulation of sucrose-seeking during unexpected reward omission. Neuron 94:388-400.

     

  11. Pare D, Quirk GJ (2017) When Scientific Paradigms Lead to Tunnel Vision: Lessons from the Study of Fear. NPJ Science of Learning, doi:10.1038/s41539-017-0007-4.

     

  12. Delgado MR, Beer JS, Fellows LK, Huettel SA, Platt ML, Quirk GJ, Schiller D. (2016) Viewpoints: Dialogues on the functional role of the ventromedial prefrontal cortex. Nature Neurosci. 19:1545-1552.

     

  13. Martinez-Rivera FJ, Rodriguez-Romaguera J, Lloret-Torres ME, Do Monte FH, Quirk GJ, Barreto-Estrada JL. (2016) Bidirectional modulation of extinction of drug seeking by deep brain stimulation of the ventral striatum. Biol. Psychiatry. 80(9):682-690.

     

  14. Do Monte FH, Quirk GJ, Li B, Penzo MA. Mol Psychiatry. (2016) Retrieving fear memories, as time  goes by…. Mol Psych. 21(8):1027-36.

     

  15. Rodriguez-Romaguera J, Greenberg BD, Rasmussen SA, Quirk GJ. (2016) An Avoidance-Based Rodent Model of Exposure With Response Prevention Therapy for Obsessive-Compulsive Disorder. Biol Psychiatry. 80(7):534-40.

     

  16. Rodriguez-Romaguera J, Greenberg BD, Haber SN, Quirk GJ. (2015) A cross species approach to understanding DBS modulation of fear. Brain Stimul. 8(5):986-8.

     

  17. Quiñones-Laracuente K, Hernández-Rodríguez MY, Bravo-Rivera C, Melendez RI, Quirk GJ. (2015) The effect of repeated exposure to ethanol on pre-existing fear memories in rats. Psychopharmacology (Berl). 232(19):3615-22.

     

  18. Bravo-Rivera C, Roman-Ortiz C, Montesinos-Cartagena M, Quirk GJ (2015) Persistent active avoidance correlates with activity in prelimbic cortex and ventral striatum.. Front Behav Neurosci. 9:184.

     

  19. Do-Monte FH, Manzano-Nieves G, Quiñones-Laracuente K, Ramos-Medina L, Quirk GJ (2015) Revisiting the Role of Infralimbic Cortex in Fear Extinction with Optogenetics . J. Neurosci. 35(8):3607-15.

     

  20. Rodriguez-Romaguera J, Do-Monte FH, Tanimura Y, Quirk GJ, Haber SN (2015) Enhancement of Fear Extinction with Deep Brain Stimulation: Evidence for Medial Orbitofrontal Involvement. Neuropsychopharmacology. 40(7):1726-33.

     

  21. Do-Monte FH, Quiñones-Laracuente K, Quirk GJ (2015) A temporal shift in the circuits mediating retrieval of fear memory. Nature. 519(7544):460-3.

     

  22. Bravo-Rivera C, Diehl MM, Roman-Ortiz C, Rodriguez-Romaguera J, Rosas-Vidal LE, Bravo-Rivera H, Quinones-Laracuente K, Do-Monte FH (2014) Long-range GABAergic neurons in the prefrontal cortex modulate behavior. J Neurophys. 114(3):1357-9.

  23. Martínez KG, Franco-Chaves JA, Milad MR, Quirk GJ (2014) Ethnic Differences in Physiological Responses to Fear Conditioned Stimuli. PLoS One. 9(12):e114977.

     

  24. Bravo-Rivera C, Roman-Ortiz C, Brignoni-Perez E, Sotres-Bayon F, Quirk GJ (2014) Neural structures mediating expression and extinction of platform–mediated avoidance. J. Neurosci. 34:9736-9742.

     

  25. Rosas-Vidal LE, Do-Monte FH, Sotres-Bayon F, Quirk GJ (2014) Hippocampal-prefrontal BDNF and memory for fear extinction. Neuropsychopharmacology 39:2161-2169.

     

  26. Do-Monte, FH, Rodriguez-Romaguera J, Rosas-Vidal LE, Quirk GJ. (2013) Deep brain stimulation of the ventral striatum increases BDNF in the fear extinction circuit. Front in Behav Sci. Epub ahead of print.

     

  27. Pendyam S, Bravo-Rivera C, Burgos-Robles A, Sotres-Bayon F, Quirk GJ, Nair SS. (2013) Fear signaling in the prelimbic-amygdala circuit: A computational modeling and recording study. J Neurophysiol. Epub ahead of print.

     

  28. Felmingham KL, Dobson-Stone C, Schofield PR, Quirk GJ, Bryant RA (2013) The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biol Psychiatry. 73(11): 1059-63.

     

  29. Burgos-Robles A, Bravo-Rivera H, Quirk GJ (2013) Prelimbic and Infralimbic Neurons Signal Distinct Aspects of Appetitive Instrumental Behavior. PLoS ONE. 8(2): e57575.

     

  30. Sotres-Bayon F, Sierra-Mercado D, Pardilla-Delgado E, Quirk GJ (2012) Gating of fear in prelimbic cortex by hippocampal and amygdala inputs. Neuron. Nov 21;76(4):804-12.

     

  31. Martinez KG, Castro-Couch M, Franco-Chaves JA, Ojeda-Arce B, Segura G, Milad MR, Quirk GJ. Correlations between psychological tests and physiological responses during fear conditioning and renewal. Biol Mood Anxiety Disord. Sep 17;2(1):16

     

  32. Rodriguez-Romaguera J, Do Monte FHM, Quirk GJ (2012) Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proc. Nat. Acad. Sci. 109:8764-8769 (Highlighted in Nature, 485:418).

     

  33. Linnman C, Zeidan MA, Furtak SC, Pitman RK, Quirk GJ, Milad MR. “Resting Amygdala and Medial Prefrontal Metabolism Predicts Functional Activation of the Fear Extinction Circuit” Am J Psychiatry. 2012 February; Epub ahead of print

     

  34. Milad MR, Quirk GJ. “Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress” Annual Review of Psychology. 2012 January 63:129-151

     

  35. Padilla-Coreano N, Do-Monte FH, Quirk GJ. “A time-dependent role of midline thalamic nuclei in the retrieval of memory” Neuropharmacology. 2011 August; Epub ahead of print

     

  36. Quirk GJ, Paré D, Richardson R, Herry C, Monfils MH, Schiller D, Vicentic A. “Erasing Fear Memories with Extinction Training” Journal of Neuroscience. 2010 September; 30(45): 14993-14997

     

  37. Sierra-Mercado D, Padilla-Coreano N, Quirk GJ. “Dissociable Roles of Prelimbic and Infralimbic Cortices, Ventral Hippocampus, and Basolateral Amygdala in the Expression of Conditioned Fear” Neuropsychopharmacology. 2010 September; 1-10

     

  38. Mueller D, Bravo-Rivera C, Quirk GJ. “Infralimbic D2 Receptors Are Necessary for Fear Extinction and Extinction-Related Tone Responses” Biol Psychiatry. 2010 August; Epub ahead of print.

     

  39. Fontanez-Nuin D, Santini E, Quirk GJ, Porter JT. “Memory for Fear Extinction Requires mGluR5-Mediated Activation of Infralimbic Neurons” Cerebral Cortex. 2010 August; Epub ahead of print.

     

  40. Peters J, Dieppa-Perea LM, Melendez LM, Quirk GJ. “Induction of Fear Extinction with Hippocampal-Infralimbic BDNF” Science. 2010 June; 328:1288-1290

         ↳ Educational Resource

     

  41. Sotres-Bayon F, Gregory GJ. “Prefrontal control of fear: more than just extinction” Curr Opin Neurobiol. 2010 April; 20: 231-235

     

  42. Quirk GJ, Milad MR. “Editing out fear” Nature. 2010 January; 463: 36-37

     

  43. Holmes A, Quirk GJ. “Pharmacological facilitation of fear extinction and the search for adjunct treatments for anxiety disorders – the case of yohimbine” Trends Pharmacol Sci. 2010 April; 31(1): 2-7

     

  44. Burgos-Robles A, Vidal-Gonzalez I, Quirk GJ. “Sustained conditioned responses in prelimbic prefrontal neurons are correlated with fear expression and extinction failure” Journal of Neuroscience. 2009 July; 29(26):8474-8482

     

  45. Quirk GJ, Sotres-Bayon F. “Signaling aversive events in the midbrain: worse than expected.” Neuron. 2009 March; 61(5):655-6

     

  46. Peters J, Kalivas PW, Quirk GJ. “Extinction circuits for fear and addiction overlap in prefrontal cortex.” Learning and Memory. 2009 April; 16(5):279-88

     

  47. Rodriguez-Romaguera J, Sotres-Bayon F, Mueller D, Quirk GJ. “Systemic Propranolol Acts Centrally to Reduce Conditioned Fear in Rats Without Impairing Extinction” Biological Psychiatry. 2009 May; 65(10): 887-92

     

  48. Mueller D, Olivera-Figueroa LA, Pine DS, Quirk GJ. “The effects of yohimbine and amphetamine on fear expression and extinction in rats.” Psychopharm. 2009 February; 204: 599-606

     

  49. Martínez KG, Quirk GJ. “Extending fear extinction beyond anxiety disorders.” Biol Psychiatry. 2009 March; 65(6):453-4

     

  50. Li G, Nair SS, Quirk GJ. “A biological realistic network model of acquisition and extinction of conditioned fear associations in lateral amygdala neurons.” J Neurophysiol. 2009 March; 101(3):1629-46

     

  51. Santini E, Quirk GJ, Porter J. “Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons.” J Neurosci. 2008 April; 28(15): 4028-4036

     

  52. Li G, Nair J, Quirk GJ, Nair SS. “Computational Modeling: A Tool for New Psychiatric Medication Development” Psychiatric Annals. 2008 April; 38(4): 294-305

     

  53. Mueller D, Porter J, Quirk GJ. “Noradrenergic signaling in infralimbic cortex increases cell excitability and strengthens memory for fear extinction.” J Neurosci. 2008 January; 28(2):369-375.

     

  54. Quirk GJ, Mueller D. “Neural Mechanisms of Extinction Learning and Retrieval” Neuropsychopharmacology, 2008 January; 33(1):56-72. Review

     

  55. Quirk GJ, Martinez KG, Nazario Rodriguez LL. “Translating findings from basic research to clinical psychiatry in Puerto Rico” PR Health Science J. 2007 December; 26(4):321-328.

  56. Milad MR, Quirk GJ, Pitman RK, Orr SP, Fischl B, Rauch SL. “A Role for the Human Anterior Cingulate Cortex in Fear Expression” Biol Psychiatry, 2007 November ; 62(10):1191-1194.

     

  57. Burgos-Robles A, Vidal-Gonzalez I, Santini E, Quirk GJ. “Consolidation of fear extinction requires NMDA receptor-dependent bursting in the ventromedial prefrontal cortex” Neuron, 2007 March;53:871-880.

     

  58. Corcoran KA and Quirk GJ. “Recalling Safety: Cooperative functions of the ventromedial prefrontal cortex ant the hippocampus in extinction”. CNS Spectr. 2007 February; 12(3):200-206.

     

  59. Corcoran KA and Quirk GJ. “Activity in prelimbic cortex is necessary for the expression of learned, but not innate, fears” J Neurosci. 2007 January;27(4):840–844.

     

  60. Milad MR, Wright CL, Orr SP, Pitman RK, Quirk GJ, Rauch SL. “Recall of fear extinction in humans activates the ventromedial prefrontal cortex and hippocampus in concert” Biological Psychiatry, 2007 January;62:446-454.

     

  61. Quirk GJ and Beer JS. “Prefrontal involvement in emotion regulation: Convergence of rat and human studies” Current Opinion in Neurobiology, 2006; 16:723–727.

     

  62. Vidal-González I, Vidal-González B, Rauch SL, and Quirk GJ. “Microstimulation reveals opposing influences of prelimbic and infralimbic cortex on the expression of conditioned fear” Learning & Memory, 2006; 13: 728-733.

     

  63. Quirk GJ and Vidal-González I. ”Keeping the memories flowing” Nature Publishing Group, 2006 October; 9(10): 1199-1200.

     

  64. Sierra-Mercado D, Corcoran KA, Lebron-Milad K, Quirk GJ. “Inactivation of ventromedial prefrontal cortex reduces expression of conditioned fear and impairs subsequent recall of extinction” European J. Neuroscience 2006 24: 1751-1758.

     

  65. Milad MR, Rauch SL, Pitman RK and Quirk GJ. “Fear extinction in rats: Implications for human brain imaging and anxiety disorders” Biological Psychiatry 2006 73: 61-71.

     

  66. Quirk GJ. “Extinction: New Excitement for an old phenomenon” Biological Psychiatry 2006 60: 317-318.

     

  67. Quirk GJ, Garcia R, and Gonzalez-Lima F. “Prefrontal mechanisms in extinction of conditioned fear” Biological Psychiatry 2006 60: 337-347.

     

  68. Anglada-Figueroa D and Quirk GJ. “Lesions of the Basal Amygdala Block Expression of Conditioned Fear But Not Extinction” J Neurosci. 2005 Oct 19; 25(42):9680-85.

     

  69. Quirk GJ and Peña de Ortiz S. “Stuck in Time Without a Nucleus: Theoretical Comment on Sangha et al. (2005)” Behav Neurosci. 2005 Mar; 119(4):1155-57.

     

  70. Maren S and Quirk GJ. “Neuronal signaling of fear memory”. Nature reviews neuroscience 2004 Nov; 5: 844-852.

     

  71. Lebron K, Milad MR, and Quirk GJ. “Delayed Recall of Fear Extinction in Rats With Lesions of Ventral Medial Prefrontal Cortex.” Learning & Memory 2004 Sep-Oct; 11: 544-548.

     

  72. Paré D, Quirk GJ, and LeDoux JE. “New Vistas on Amygdala Networks in Conditioned Fear” J Neurophysiol. 2004 July; 92: 1-9.

     

  73. Santini E, Hong Ge, Kequin Ren, Peña de Ortiz S, and Quirk GJ. “Consolidation of Fear Extinction Requires Protein Synthesis in the Medial Prefrontal Cortex.” J Neurosci. 2004 Jun 23; 24(25):5704-10.

     

  74. Quirk GJ. “Learning not to fear, faster” Learning & Memory 2004 11: 125-126.

     

  75. Milad MR, Vidal-González I and Quirk GJ. “Electrical stimulation of medial prefrontal cortex reduces conditioned fear in a temporally specific manner” Behav Neurosci. 2004 Apr; 118(2):389-94.

     

  76. Quirk GJ, Likhtik E, Pelletier JG and Paré D. “Stimulation of medial prefrontal cortex decreases the responsiveness of central amygdala output neurons” J Neurosci. 2003 Sep 24; 23(25):8800-8807.

     

  77. Quirk GJ, Gehlert DR. “Inhibition of the amygdala: key to pathological states?” Ann N Y Acad Sci. 2003 Apr; 985:263-72.

     

  78. Quirk GJ. “Memory for Extinction of Conditioned Fear Is Long-lasting and Persists Following Spontaneous Recovery” Learn Mem. 2002 Nov-Dec; 9(6):402-427.

     

  79. Milad MR and Quirk GJ. “Neurons in medial prefrontal cortex signal memory for fear extinction” Nature 2002 Nov 7; 240:70-74.

     

  80. Santini E, Muller RU, and Quirk GJ. “Consolidation of Extinction Learning Involves Transfer from NMDA-Independent to NMDA Dependent Memory.” J Neurosci. 2001 Nov 15; 21(22):9009-17.

     

  81. Quirk GJ, Russo GK, Barron JL, and Lebron K. “The Role of Ventromedial Prefrontal Cortex in the Recovery of Extinguished Fear.” J Neurosci. 2000 Aug 15; 20(16):6225-31.

     

  82. Armony JL, Quirk GJ, and LeDoux JE. “Differential Effects of Amygdala Lesions on Early and Late Plastic Components of Auditory Spike Trains during Fear Conditioning.” J Neurosci. 1998 Apr 1; 18(7):2592-601.

     

  83. Quirk GJ, Armony JL, and LeDoux JE. “Fear Conditioning Enhances Different Temporal Components of Tone-Evoked Spike Trains in Auditory Cortex and Lateral Amygdala.” Neuron, 1997 Sep; 19(3):613-24.