My laboratory is interested in the role of the central norepinephrine’s (NE) system in cocaine addiction and epilepsy. Our recent work investigates the role of the NE system in the development of cocaine sensitization, a progressive and lasting enhancement in the motor stimulant effect induced by a subsequent drug challenge. Experiments include the use of animal models, western blots, systemic and iontophoretic administration of NE agonists and antagonists together with in vivo electrophysiological recordings. Whole cell patch clamp neurophysiologic recording techniques in in vitro brain slices are also employed to understand the basic biophysical mechanisms of cocaine addiction. The completion of these investigations will provide important information of whether a dysfunction of NE’s modulatory properties is an important factor in the development of cocaine addiction and could suggest possible avenues for therapeutic pharmacological interventions.