Dr. Nelson Escobales

Professor

Contact Info

Education

  • B.S. 1977, Biology, University of Puerto Rico, Mayaguez, PR
  • M.S. 1977, Biology, University of Puerto Rico, Mayaguez, PR
  • Ph.D. 1982, Physiology, Univ. of PR, School of Medicine, San Juan, PR
  • Postdoc 1984, Physiology, Harvard Medical School, Boston, MA

RESEARCH INTEREST

Membrane transport of ions and organic solutes, cardiovascular physiology and pathophysiology, the renin-angiotensin-system.

Laboratory Members

Miriam Castro, Research Specialist

PUBLICATIONS

  • Mitochondrial angiotensin receptors and cardioprotective pathways.
    Escobales N, Nuñez RE, Javadov S. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1426-H1438. doi: 10.1152/ajpheart.00772.2018. Epub 2019 Apr 12.
    PMID: 30978131 Review.
  • Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts. Nuñez RE, Javadov S, Escobales N. Pflugers Arch. 2018 Sep;470(9):1391-1403. doi: 10.1007/s00424-018-2153-9. Epub 2018 May 10. PMID: 29748710
  • Angiotensin II-preconditioning is associated with increased PKCε/PKCδ ratio and prosurvival kinases in mitochondria. Nuñez RE, Javadov S, Escobales N. Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1201-1212. doi: 10.1111/1440-1681.12816. Epub 2017 Sep 20. PMID: 28707739
  • The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion. Javadov S, Escobales N. J Pharm Pharm Sci. 2015;18(3):547-50. doi: 10.18433/j3nw2k. PMID: 26517140
  • Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016/j.yjmcc.2014.10.009. Epub 2014 Oct 23. PMID: 25451170
  • Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. Nuñez RE, Castro M, Javadov S, Escobales N. J Cardiovasc Pharmacol. 2014 Aug;64(2):172-9. doi: 10.1097/FJC.0000000000000103. PMID: 24705171
  • Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster. Escobales N, Crespo MJ. P R Health Sci J. 2008 Dec;27(4):307-14. PMID: 19069355 Review.
  • Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress. Escobales N, Crespo MJ. Vascul Pharmacol. 2006 Jan;44(1):22-8. doi: 10.1016/j.vph.2005.09.008. Epub 2005 Nov 21.
    PMID: 16301003
  • Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells.
    Escobales N, Castro M, Altieri PI, Sanabria P. J Cardiovasc Pharmacol. 1996 Mar;27(3):383-91. doi: 10.1097/00005344-199603000-00011. PMID: 8907800
  • The Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension. Canessa M, Brugnara C, Escobales N. Hypertension. 1987 Nov;10(5 Pt 2):I4-10. doi: 10.1161/01.hyp.10.5_pt_2.i4. PMID: 2824364 Review.
  •  Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Escobales N, Rivera-Correa M, Altieri PI, Rodriguez JF. Amino Acids. 2000;19(2):451-68. doi: 10.1007/s007260070023.
    PMID: 11128552
  • Amiloride-sensitive Na+ transport in human red cells: evidence for a Na/H exchange system. Escobales N, Canessa M.J Membr Biol. 1986;90(1):21-8. doi:10.1007/BF01869682. PMID: 3009823
  • Osmotic activation of Na(+)-H+ exchange in human endothelial cells. Escobales N, Longo E, Cragoe EJ Jr, Danthuluri NR, Brock TA.Am J Physiol. 1990 Oct;259(4 Pt 1):C640-6. doi: 10.1152/ajpcell.1990.259.4.C640. PMID: 2171349
  • Na+ for H+ exchange in rabbit erythrocytes. Escobales N, Rivera A. J Cell Physiol. 1987 Jul;132(1):73-80. doi: 10.1002/jcp.1041320110. PMID: 3036894
  • Ca2+-activated Na+ fluxes in human red cells. Amiloride sensitivity. Escobales N, Canessa M. J Biol Chem. 1985 Oct 5;260(22):11914-23. PMID: 3930487