Dr. Nelson Escobales



B.S. 1977BiologyUniversity of Puerto Rico, Mayaguez, PR
M.S. 1977BiologyUniversity of Puerto Rico, Mayaguez, PR
Ph.D. 1982PhysiologyUniv. of PR, School of Medicine, San Juan, PR
Postdoc 1984PhysiologyHarvard Medical School, Boston, MA


Membrane transport of ions and organic solutes, cardiovascular physiology and pathophysiology, the renin-angiotensin-system.

Laboratory Members

Miriam Castro, Research Specialist


  • Mitochondrial angiotensin receptors and cardioprotective pathways.
    Escobales N, Nuñez RE, Javadov S. Am J Physiol Heart Circ Physiol. 2019 Jun 1;316(6):H1426-H1438. doi: 10.1152/ajpheart.00772.2018. Epub 2019 Apr 12.
    PMID: 30978131 Review.
  • Critical role of angiotensin II type 2 receptors in the control of mitochondrial and cardiac function in angiotensin II-preconditioned rat hearts. Nuñez RE, Javadov S, Escobales N. Pflugers Arch. 2018 Sep;470(9):1391-1403. doi: 10.1007/s00424-018-2153-9. Epub 2018 May 10. PMID: 29748710
  • Angiotensin II-preconditioning is associated with increased PKCε/PKCδ ratio and prosurvival kinases in mitochondria. Nuñez RE, Javadov S, Escobales N. Clin Exp Pharmacol Physiol. 2017 Dec;44(12):1201-1212. doi: 10.1111/1440-1681.12816. Epub 2017 Sep 20. PMID: 28707739
  • The Role of SIRT3 in Mediating Cardioprotective Effects of RAS Inhibition on Cardiac Ischemia-Reperfusion. Javadov S, Escobales N. J Pharm Pharm Sci. 2015;18(3):547-50. doi: 10.18433/j3nw2k. PMID: 26517140
  • Mitochondria-targeted ROS scavenger improves post-ischemic recovery of cardiac function and attenuates mitochondrial abnormalities in aged rats. Escobales N, Nuñez RE, Jang S, Parodi-Rullan R, Ayala-Peña S, Sacher JR, Skoda EM, Wipf P, Frontera W, Javadov S. J Mol Cell Cardiol. 2014 Dec;77:136-46. doi: 10.1016/j.yjmcc.2014.10.009. Epub 2014 Oct 23. PMID: 25451170
  • Angiotensin II and ischemic preconditioning synergize to improve mitochondrial function while showing additive effects on ventricular postischemic recovery. Nuñez RE, Castro M, Javadov S, Escobales N. J Cardiovasc Pharmacol. 2014 Aug;64(2):172-9. doi: 10.1097/FJC.0000000000000103. PMID: 24705171
  • Early pathophysiological alterations in experimental cardiomyopathy: the Syrian cardiomyopathic hamster. Escobales N, Crespo MJ. P R Health Sci J. 2008 Dec;27(4):307-14. PMID: 19069355 Review.
  • Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress. Escobales N, Crespo MJ. Vascul Pharmacol. 2006 Jan;44(1):22-8. doi: 10.1016/j.vph.2005.09.008. Epub 2005 Nov 21.
    PMID: 16301003
  • Simvastatin releases Ca2+ from a thapsigargin-sensitive pool and inhibits InsP3-dependent Ca2+ mobilization in vascular smooth muscle cells.
    Escobales N, Castro M, Altieri PI, Sanabria P. J Cardiovasc Pharmacol. 1996 Mar;27(3):383-91. doi: 10.1097/00005344-199603000-00011. PMID: 8907800
  • The Li+-Na+ exchange and Na+-K+-Cl- cotransport systems in essential hypertension. Canessa M, Brugnara C, Escobales N. Hypertension. 1987 Nov;10(5 Pt 2):I4-10. doi: 10.1161/01.hyp.10.5_pt_2.i4. PMID: 2824364 Review.
  •  Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Escobales N, Rivera-Correa M, Altieri PI, Rodriguez JF. Amino Acids. 2000;19(2):451-68. doi: 10.1007/s007260070023.
    PMID: 11128552
  • Amiloride-sensitive Na+ transport in human red cells: evidence for a Na/H exchange system. Escobales N, Canessa M.J Membr Biol. 1986;90(1):21-8. doi:10.1007/BF01869682. PMID: 3009823
  • Osmotic activation of Na(+)-H+ exchange in human endothelial cells. Escobales N, Longo E, Cragoe EJ Jr, Danthuluri NR, Brock TA.Am J Physiol. 1990 Oct;259(4 Pt 1):C640-6. doi: 10.1152/ajpcell.1990.259.4.C640. PMID: 2171349
  • Na+ for H+ exchange in rabbit erythrocytes. Escobales N, Rivera A. J Cell Physiol. 1987 Jul;132(1):73-80. doi: 10.1002/jcp.1041320110. PMID: 3036894
  • Ca2+-activated Na+ fluxes in human red cells. Amiloride sensitivity. Escobales N, Canessa M. J Biol Chem. 1985 Oct 5;260(22):11914-23. PMID: 3930487


Phone:  787-758-2525, ext. 1612
Office/Laboratory number: A-680, A-663