Dr. Nelson Escobales, 
Professor and Director

Education and Training:

Postdoctoral Training: Harvard Medical School, 1984            
Ph.D., Univ. of Puerto Rico-School of Medicine, 1982
B.S. & M.Sci.,  Univ. of Puerto Rico-Mayaguez, 1977

Office phone number:   787-758-2525, ext. 1612
Office/Laboratory number: A-680, A-663 
Email: nelson.escobales@upr.edu

Research Interests

Research programs in Dr. Escobales’s laboratory investigate the role of the renin-angiotensin system (RAS) in cardiovascular pathologies. Most of these studies use the Syrian cardiomyopathic hamster as an animal model of heart failure. In its initial stages, heart disease in this model develops with focal necrosis and microinfarcts of the coronary circulation. These alterations are associated with RAS upregulation in the vasculature and increased Ang II-dependent, coronary resistance in young animals. Recent activities of our laboratory study the preconditioning effect of angiotensin II in the heart and its relationship with ischemic preconditioning.

Laboratory Members:

Miriam Castro, Research Specialist
Rebeca E. Nuñez, Ph.D. Student

Representative Publications:

  1. Crespo MJ, Cangiano JL, Altieri PI, Escobales N. Aliskiren improves left ventricular dysfunction and reduces cardiac dilation in Syrian cardiomyopathic hamsters. J Cardiovasc Pharmacol. 2012;59(6):547-52.

  2. Escobales N, Ramos J, Santacana GE, Crespo MJ. Hemodynamic alterations in the coronary circulation of cardiomyopathic hamsters: age and Ang II-dependent mechanisms. J Card Fail. 2009, 15(10):929-38.

  3. Escobales N, Crespo MJ. Angiotensin II-dependent vascular alterations in young cardiomyopathic hamsters: role for oxidative stress. Vasc Pharmacol, 2006; 44: 22-28.

  4. Escobales N, Rivera-Correa MM, Altieri PI, and Rodriguez JF. Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Amino Acids. 2000;19:451-468.

  5. Crespo MJ, Escobales N, Altieri PI. Altered vascular function in early stages of heart failure in hamsters. J. Cardiac Failure. 1997;3(4):311-318.

  6. Escobales N, Rivera-Correa M, Altieri PI, Rodriguez JF. Relationship between NO synthesis, arginine transport, and intracellular arginine levels in vascular smooth muscle cells. Amino Acids. 2000;19(2):451-68.

  7. Escobales N, Longo EA, Danthulury NR, Brock TA. Osmotic activation of Na/H exchange in human endothelial cells. Amer. J. Physiol. 1990;259(Cell Physiol. 28):C640-646.