Maria J. Crespo, Professor

Phone: (787) 758-2525 ext. 5078, 1913

Research Interests

My research interests are in the area of cardiovascular Physiology and Pharmacology, especially in pathophysiological conditions such as hypertension and congestive heart failure. In particular, I am interested in understanding the mechanism underlying endothelial dysfunction and the vascular modifications present in these conditions. We study alterations in the nitric oxide (NO) signal transduction pathway and in the renin-angiotensin system (RAS) using animal models of hypertension and heart failure.


Selected Publications

  • Crespo MJ, Roman M, Matias J, Morales M, Torres H, Quidgley J. Synergistic effects of Dantrolene and Nimodipine in Reducing PHE-induced Contraction and in Improving ACh-induced Relaxation in the Vasculature of Type-1 Diabetic Rats. Int J Endocrinol. vol. 2018, Article ID 9790303, 10 pages, 2018. doi:10.1155/2018/9790303.
  • Cruz N, Miranda JD, Crespo MJ. Modulation of Vascular ACE by Oxidative Stress in Young Syrian Cardiomyopathic Hamsters: Therapeutic Implications. J Clin Med. 2016 Jul 13;5(7). pii: E64. doi: 10.3390/jcm5070064. PubMed PMID: 27420103;PubMed Central PMCID: PMC4961995.
  • Crespo MJ, Quidgley J. Simvastatin, atorvastatin, and pravastatin equally improve the hemodynamic status of diabetic rats. World J Diabetes. 2015;6(10):1168-78.
  • González W, Altieri PI, Banchs H, Iravedra D, Calderón R, , González- Cancel I, Gurrea  C, Nelson Escobales N and Crespo M. HDL as a Biomarker of Rejection in Heart Transplant. Glob J Obes Diabetes Metab Syndr 2014;1(1): 101-106.
  • Quidgley J, Cruz N, Crespo MJ. Atorvastatin Improves Systolic Dysfunction but Does Not Prevent the Development of Dilated Cardiomyopathy in Streptozotocin-induced Diabetic Rats. Therapeutic Advances in CV Disease 2014;8(4):133-144
  • Crespo MJ, Cruz N, Quidgley J, Torres H, Hernández C, Casiano H, Rivera K,. Daily Administration of Atorvastatin and Simvastatin for One Week Improves Cardiac Function in Type 1 Diabetic Rats. Pharmacology. 2014;93(1-2):84-91
  • Bou E, Hernandez P, Cerezo L, Altieri PI, Gurrea C, Figueroa R, Garcia P, Gonzalez-Cancel I, Defendini E, , Escobales N,Crespo M, Banchs H. Heart tumors in Puerto Rico; De Novo Atrial Fibrillation as Clinical Presentation in a Subgroup of Patients. P R Health Sci J. 2013;32(1):14-17.
  • Crespo MJ, Cangiano J, Altieri PI, Escobales N. Aliskiren Improves Left Ventricular Dysfunction and Reduces Cardiac Dilation in Syrian Cardiomyopathic Hamsters. J Cardiovasc Pharmacol 2012;59(6):547-542
  • Altieri, Pablo I., José M. Marcial, Nelson Escobales, María Crespo, and Héctor L. Banchs. “The Metabolic Syndrome in Hispanics–The Role of Insulin Resistance and Inflammation.” In: Insulin Resistance. 2012; Chapter 4, pg. 75-86. Intech Publisher. ( 10.5772/50337)
  • Altieri PI, Figueroa Y, Banch H, Gil de Lamadrid J, Escobales N,Crespo MJ. Metabolic Syndrome in an Hispanic Population-Cardiovascular Complications.” QScience Connect 2011;5 doi:10.5539/connect.2011
  • Crespo MJ, Marrero M, Cruz N, Quidgley J, Creagh O, Torres H, Rivera K. Diabetes alters cardiovascular responses to anaesthetic induction agents in STZ-diabetic rats. Diab Vasc Dis Res. 2011;8(4):299-302.
  • Crespo MJ, Cruz N, Altieri PI, and Escobales N. Chronic Treatment with N-acetylcysteine (NAC) Improves Cardiac Function but Does Not Prevent Progression of Cardiomyopathy in Syrian Cardiomyopathic Hamsters. J Cardiovasc Pharmacol Ther. 2011;16(2):197-204
  • Marcial JM, Altieri PI, Banch H, Escobales N,Crespo M. Metabolic Syndrome Among Puerto Ricans and other Hispanic Populations. P R Health Sci J. 2011;30(3):145-151
  • Escobales N, Ramos JA, Santacana G,Crespo MJ. Hemodynamic Alterations in the Coronary Circulation of Cardiomyopathic Hamsters: Age and Ang II-dependent mechanisms. J Card Fail. 2009;15(10):929-38
  • Crespo MJ, Cruz N, Altieri PI, Escobales N.  RAS inhibition is more effective than b-blockade in preventing dilated cardiomyopathy in the Syrian Cardiomyopathic Hamster. J Cardiovasc Pharmacol Ther.  2008;13(3):199-206.
  • Escobales N,Crespo MJ. Early pathophysiological alterations in experimental cardiomyopathy: The Syrian Cardiomyopathic Hamsters. P R Health Sci J. 2008;27(4):307-314
  • Mundo_Sagardia JA, Figueroa Y, Altieri PI, Banch H, Escobales N,Crespo MJ. The atherosclerotic plaque.  P R Health Sci J. 2008;37(3):241-246
  • Crespo MJ, Zalacain J, Dunbar D, Cruz N, and Arocho L. Oxidative Stress is elevated at the Onset of Dilated Cardiomyopathy in STZ-diabetic Rats. J Cardiovasc Pharmacol Ther 2008; 13(1):64-71
  • Figueroa Y, Altieri PI, Banch H, Hernandez J, Lopez JC, Escobales N,Crespo M. Syncope in Puerto Rico. Bol Asoc Med PR 2007;99(3):207-210
  • Cruz N, Arocho L, Rosario L,Crespo MJ. Chronic administration of Carvedilol
    improves cardiac function of 6-month-old Syrian cardiomyopathic hamsters.
    Pharmacology 2007. 2007;80:144-150
  • Figueroa Y, Altieri PI, Banch H, Escobales N,Crespo M, Defendini E, Gonzalez-Cancel I. Coronary Artery Abnormalities in Puerto Rico. P R Health Sci J. 2006;25(3):225-227
  • Crespo MJ, Quidgley J, Dunbar D. Differential Regulation of Left and Right Coronary Arteries of Swine. Pharmacology 2006;77:137-143
  • Crespo MJ, Altieri PI, Escobales N. Enhanced Contractility of Ang II in the Aorta of Cardiomyopathic Hamsters is Mediated by an Increased Ang II-Binding Capacity and Release of ET-1. Vasc Pharmacol. 2006;44(4):247-252
  • Crespo MJ,Quidgley J. Statins decrease serotonin-induced contraction in coronary arteries of swine.Pharmacology2006;76:141-147
  • Escobales N,Crespo MJ.Angiotensin II-dependent Vascular Alterations in Young Cardiomyopathic Hamsters: Role of Oxidative Stress.Vasc Pharmacol. 2006;44(1):22-28
  • Escobales N, Crespo MJ. Oxidative-nitrosative Stress in Hypertension.Curr Vasc Pharmacol. 2005;3(3)231-246
  • Guerra J, De Jesus A, Santiago-Borrero P, Roman-Franco A, Rodríguez E,Crespo MJ.Plasma Nitric Oxide Levels Used as an Indicator of Doxorubicin-induced Cardiotoxicity.Hematol J.2005;5(7):584-8
  • Altieri PI, Banch H, Escobales N,Crespo MJ,Rodriguez-Orengo J. The Role of Angiotensin Converting Enzyme-inhibitors and Angiotensin II Receptors Blockers in the Management of Arrhythmias and Atrial Fibrillation.Ital Heart J2004;5(Suppl 1):39S-41S
  • Altieri PI, Colon E, Rodriguez-Orengo J, Escobales N, Banch H,Crespo MJ,Figueroa Y. Quantitative analysis of the Vein Drainage to the Right atrium by Cardiovascular Magnetic Resonance in Patients With Chronic and Intermittent Atrial Fibrillation.Ital Heart J2004;5(Suppl 1):124S-127S
  • Crespo MJ, Dunbar DC . Enalapril Improves Vascular and Cardiac Function in STZ-diabetic Rats.Mol Cell Biol2003;49(8) 1311-1318
  • González-Pérez J,Crespo MJ.Chronic Effects of Selective Estrogen Receptor Modulator Toremifene on the Vasculature of Menopause-induced Rats.Vasc Pharmacol2003:40(5):261-268
  • Crespo MJ, Moreta S, Gonzalez J. Cardiovascular Deterioration in STZ-diabetic Rats: Possible Role of Vascular RAS. Pharmacology2003;68(1)1-8
  • Altieri PI, Escobales N, Rodriguez-Orengo J, Banch H,Crespo MJ.The Effect of Enalaprilat and Losartan in QT Dispersion.Proceedings of the XIIth World Congress on Cardiac Pacing and Electrophysiology.Monduzzi Editore 2003, pp. 957-961
  • Mundo-Sagardía J, Altieri PI, Banch H, González R, Escobales N,Crespo MJ,Rodriguez-Orengo J, Cardona F, Torrado J. El rol de la endotelina 1 y la angiotensina II en diabéticos tipoII con enfermedad coronaria.Boletin de la Asoc Med. de Puerto Rico.2003;95(5):45-50
  • Mundo-Sagardía J, Altieri PI, Banch H, González R, Escobales N,Crespo MJ,Rodriguez-Orengo J, Cardona F, Torrado J. La relación entre los niveles coronarios de endotelina I y de angiotensina II y el diámetro de vasos coronarios en diabéticos tipo 2 con enfermedad coronaria.Rev. Lat. Cardiol. 2003;24(1):24-27
  • González-Pérez J,Crespo MJ.Acute Effects of Toremifene on the Vasculature of Intact and Menopause-induced Rats.Vasc Pharmacol2003;40(4):205-211
  • Altieri PI, Escobales N, Rodriguez-Orengo J,Crespo-Bellido MJ, Banch H. El alcohol y las cardiomiopatías, mecanismos.Rev Lat Cardiol2002;23(2):66-67
  • Altieri PI, Escobales N, Rodriguez-Orengo J,Crespo-Bellido MJ, Banch H. El papel del vino tinto en los síndromes coronarios agudos.Rev Lat Cardiol2002;23(2):68-69
  • Altieri-Nieto PI, Escobales-Alicea N, Rodríguez-Orengo JF, Banchs-Pieretti H,Crespo-BellidoMJ.The Effect of Angiotensin II Receptor Blockers and Converting Enzyme Inhibitors in QT Dispersion.Giornale Italiano di Aritmologia e Cardiostimolazione2002; 5(S1):129-130
  • Crespo MJ, WC de Mello. Chronic Administration of Losartan plus Hydrochlorothiazide Improves Vascular Status in Young Cardiomyopathic Hamsters.Eur J Pharmacol2001;420 (2-3):133-141
  • Crespo MJ.Interaction between AT-1 and Alpha-1 Adrenergic Receptors in Cardiomyopathic Hamsters.J Cardiac Failure2000;6(3):257-263
  • De Mello WC,Crespo MJ.Correlation between Changes in Morphology, Electrical Properties, and Angiotensin‑converting Enzyme Activity in the Failing Heart.Eur J Pharmacol1999;378(2):187‑94.
  • Altieri PI,Crespo MJ, Escobales N, Rodriguez JF, Banch H. The antiarrhythmic properties of angiotensin converting enzyme inhibitors and angiotensin II blockers.G Ital Cardiol1999;29(Suppl 5)442-444
  • Crespo MJ, Altieri PI, Escobales N. Vastatins Compete with Norepinephrine for the Alpha-1 Receptor in Rat Aorta.Proceedings of the XXI Congress of European Society of CardiologyMonduzzi Editore , Italy -MediMond, USA , 1999. pp. 243-250
  • Crespo MJ. Vascular Alterations During the Development and Progression of Experimental Heart Failure. J Cardiac Failure1999;5(1):55-63
  • Altieri PI, González R, Escobales N,Crespo MJ, Banch H. Myocardial Remodeling in Hypertensive Patients. The Role of Converting Enzyme Inhibitions and Angiotensin II Receptor Blockers in Reducing Ventricular Arrhythmia.G Ital Cardiol1998;28(1)353-356
  • Altieri PI, González , Escobales N, González R, Banch H,Crespo MJ.Lower Incidence of Coronary disease in Puerto Rico ( USA Island ) than in the Continental USA: a Possible Protective Effect of a Lower LDL/HDL Lipoprotein Ratio.Proceedings of the XIII World Congress of CardiologyMonduzzi Editore- 1998, pp. 13-16
  • Altieri PI, González R, Escobales N,Crespo MJ,Banch H. Remodelado Miocardico y Vascular en los Pacientes Hipertensos. Papel de los Inhibidores de la Enzyma Convertidora y de los Bloqueadores de los Receptores de Angiotensina II.Rev Lat Cardiol1997;18:55-60
  • Crespo MJ, Escobales N, Altieri PI. Altered Vascular Function in Early Stages of Heart Failure in Hamsters. J Cardiac Failure1997;3 (4)311-318
  • Escobales N,Crespo MJ, Altieri PI, Furilla R. Inhibition of Smooth Muscle Cell Calcium Mobilization and Aortic Ring Contraction by Lactone Vastatins.J Hypertens1996;14(1):115-121
  • Crespo MJ, Escobales N, Rodriguez‑Sargent C. Endothelial Dysfunction in the San Juan Hypertensive Rat; Possible Role of Nitric Oxide Synthase.J Cardiovasc Pharmacol.1996;27(6) 802-808
  • De Mello WC,Crespo MJ.Cardiac Refractoriness in the Rat Is Reduced by Angiotensin II.J Cardiovasc Pharmacol1995; 25(1):51‑56
  • De Mello WC,Crespo MJ,Altieri PI. Effect of Enalapril on Intracellular Resistance and Conduction Velocity in Rat Ventricular Muscle.J Cardiovasc Pharmacol.1993;22: 259‑263
  • De Mello WC,Crespo MJ,Altieri PI. Enalapril Increases Cardiac Refractoriness.J Cardiovasc Pharmacol1992;20:820‑825
  • Altieri PI, De Mello W, Escobales N, Gonzales R,Crespo MJ.Enalapril in Congestive Heart Failure and Arrhythmias.New Trends in Arrhythmias1992;7(4):1031‑1042
  • Vega CA ,Crespo MJ.Dissociation Constants of Primary Phosphate Ion for pH Control in 20 and 50 wt% 1‑propanol plus water solvents from 37 to 10 C.J Chem Eng Data1990; 35(4): 404‑406