Neonatology section faculty

Lourdes García-Fragoso MD FAAP Neonatology Section Director, Zayhara Reyes-Bou MD FAAP – Program Director, Inés García-García MD FAAP, Juan Rivera-González MD FAAP, Israel Matías-González MD FAAP, Norma Claudio-Figueroa MD FAAP

Dra. Lourdes García-Fragoso

Lourdes García-Fragoso MD FAAP

UPR School of Medicine
Department of Pediatrics
Neonatology Section

787-777-3225 / 787-474-0333 ext. 7218
Fax 787-758-5307



The University of Puerto Rico, School of Medicine, Department of Pediatrics, Neonatology section has a group of Board-Certified Neonatologists who provide excellent care to sick neonates at the University Pediatric Hospital in the Puerto Rico Medical Center in San Juan, Puerto Rico. The 50-bed Neonatal Intensive Care Unit (NICU) is located on the 6th floor. Our Level IV NICU unit services high-risk infants from all over the island.  This unit has a full range of pediatric medical and surgical subspecialists and provides surgical repair of complex congenital and acquired conditions.


We have the only high-risk clinic on the island for developmental follow-up of infants discharged from the NICU.  Our neonatologists also provide care at the Fetal-Maternal Unit, Pre-partum Care and Delivery room, located in the University District Hospital, a participating institution affiliated with the University of Puerto Rico Medical Sciences Campus.

Welcome to our web page!


Neonatal Intensive Care Unit
University Pediatric Hospital
Sixth Floor
San Juan, Puerto Rico

UPR School of Medicine
Department of Pediatrics
Neonatology section
PO BOX 365067
San Juan, Puerto Rico 00936-5067

787-777-3225 / 787-474-0333 ext. 7218
Fax:   787-758-5307


Neonatology Section Core Faculty

Lourdes García-Fragoso MD FAAP – Neonatology Section Chair; Neonatology Research Affairs Director

Zayhara Reyes-Bou MD FAAP – Neonatal-Perinatal Medicine Fellowship Program Director

Inés García-García MD FAAP – Neonatology Academic Affairs Director

Juan Rivera-González MD FAAP- Neonatology Clinical Affairs Director

Israel Matías-González MD FAAP – NRP Course coordinator

Norma Claudio-Figueroa MD FAAP – NRP Course coordinator


Neonatologists                                                    Emails                                                                                   

Dr. Alvaro Santaella-Jiménez                   

Dr. Amarilis Rivera-Marrero                    

Dr. Inés García-García                               

Dr. Israel Matías-González                       

Dr. Jennifer Claudio-Malavé                    

Dr. Juan Rivera-González                         

Dr. Kary Bouet-Rivera                               

Dr. Leticia Gely-Rojas                                

Dr. Lourdes García-Fragoso                      

Dr. Luis Rodríguez-Maldonado                

Dr. Maricarmen Burgos-Rios                   

Dr. Neichma Fargas-Berrios                     

Dr. Norma Claudio-Figueroa                  

Dr. Rebeca Fuentes-Rodríguez                

Dr. Yazmin Ortiz-Sánchez                         

Dr. Yiamira Oquendo-Ocasio                   

Dr. Zayhara Reyes-Bou                             


Pediatricians – House Staff           

Dr. Annie Guiven

Dr. Edgar Acevedo

Dr. Jose Vicens

Dr. Juanita Negrón

Dr. Naomi Ríos

Dr. Rocheline Figueroa

Dr. Thea Calderón


The Neonatology Section provides its services principally at the University Pediatric Hospital, located at the Puerto Rico Medical Center in San Juan, Puerto Rico. The Section provides state-of-the-art, comprehensive specialty care to neonates with a wide range of congenital and acquired conditions and diseases. Our team of professionals provides supportive, family-centered care in a technological environment. The Section’s expertise spans the care of extremely premature infants to the care of infants with various medical and surgical illnesses.

Our Level IV Neonatal Intensive Care Unit provides intensive medical, surgical, and nursing care, life support systems, electronic monitoring, and a complete range of diagnostic capabilities. We provide a full range of respiratory support, including conventional and high-frequency ventilation and inhaled nitric oxide.

The Section has expertise in the following areas, among others:

  • Whole body cooling therapy
  • Congenital anomalies
  • Genetic disorders
  • Hyperbilirubinemia
  • Metabolic Disorders
  • Prenatal/perinatal acquired infections
  • Prematurity
  • Pulmonary hypertension
  • Respiratory distress/chronic lung disease
  • Retinopathy of prematurity
  • Surgical conditions
  • Neonatal feeding disorders

Core Faculty of the Neonatology Section

Dr. Lourdes García-Fragoso FAAP           

Dr. Inés García-García FAAP                    

Dr. Juan Rivera-González FAAP               

Dr. Zayhara Reyes-Bou FAAP                  

Dr. Norma Claudio-Figueroa FAAP         

Dr. Israel Matías-González FAAP            



Neonatal Intensive Care Unit
University Pediatric Hospital
Sixth Floor
San Juan, Puerto Rico


UPR School of Medicine
Department of Pediatrics
Neonatology section
PO BOX 365067
San Juan, Puerto Rico 00936-5067

787-777-3225, 787-474-0333 ext. 7218
Fax:   787-758-5307

Neonatology Section Research Program

There is a research program with active participation of the faculty.  The faculty mentors the Neonatology Fellowship and Pediatrics residents’ research programs. The Neonatology Section participates in the Vermont Oxford Network and obtains epidemiological data about sick neonates using prospective data collection of infants admitted to the Neonatal Service.  This provides ample opportunities for research in a large sample of subjects.  This data is available for research development by the faculty and the residents.  The results of research studies are presented in different local, national, and international forums.


  1. Valeria S. Fadhe- Hernández, Karla N. Sánchez-Contreras, Cynthia García-Coll, José Martínez-González, Zayhara Reyes-Bou, Lourdes García-Fragoso, Inés García-García, Edmarie Sánchez-Cintrón, Andrea C. Morale-Dávila, Amaris D. Rosado-Rodríguez & Andrea N. Cabrer-Masquida. Screening of postnatal maternal mental health in a level IV Neonatal Intensive Care unit. Salud y Conducta Humana 2021 Vol 8 No.1 pp 114-130.
  2. Vizcarrondo-Oppenheimer M, García-Coll C, Martínez-González J, Reyes-Bou Z, García-Fragoso L, Sanchez D, Torres A, Diaz M & García-García I.  Cumulative risk factors and mental health of mothers of infants admitted to the neonatal intensive care unit. J Matern Fetal Neonatal Med. 2021;34(4):660-662. doi:10.1080/14767058.2019.1610732.
  3. Carmen D. Zorrilla, Juana I. Rivera-Viñas, Alberto De La Vega-Pujols, Inés Garcia-Garcia, Silvia E. Rabionet, Ana M. Mosquera. The Zika Virus Infection in Pregnancy: Review and Implications for Research and Care of Women and Infants in Affected Areas. PR Health Sci J 2018;37(Special Issue):S66-S72.
  4. Leticia Gely-Rojas, Raúl Pérez, Lourdes García-Fragoso, Inés García-García. Association of Zika Virus Exposure in Utero with Ocular Phenotypes in a Group of Newborns in Puerto Rico. P R Health Sci J 2018;37(Special Issue):S77-S80.
  5. Nicolle M. Dávila-Castrodad, MD; Zayhara Reyes-Bou, MD; Maria Correa-Rivas, MD; Juan L. Perez-Berenguer, MD; Lorena Di-Pasquale, MD; Ines García-García, MD. First Autopsy of a Newborn with Congenital Zika Syndrome in Puerto Rico. PR Health Sci J 2018;37(Special Issue):S81-S84.
  6. Leticia Gely-Rojas MD; Lourdes García-Fragoso MD; Juanita Negrón, MD; Daymara Deynes; Carmen D. Zorrilla, MD; Inés García-García, MD. Congenital Zika Syndrome in Puerto Rico, Beyond Microcephaly, a Multiorgan Approach. PR Health Sci J 2018;37(Special Issue):S73-S76
  7. Inés O. Esquilín-Rivera, Gloria Reyes-Báez, Raúl Pérez-Torres. Ethical Issues during Zika Epidemic in Puerto Rico and the Americas. PR Health Sci J 2018;37(Special Issue):S41-S44.
  8. Carmen D. Zorrilla, Inés García García, Lourdes García Fragoso and Alberto De La Vega. Zika Virus Infection in Pregnancy: Maternal, Fetal, and Neonatal Considerations. J Infect Dis 2017; 216(S10):S891–6.
  9. Zappitelli M1, Ambalavanan N2, Askenazi DJ3, Moxey-Mims MM4, Kimmel PL4, Star RA4, Abitbol CL5, Brophy PD6, Hidalgo G7, Hanna M8, Morgan CM9, Raju TNK10, Ray P, Reyes-Bou Z12, Roushdi A13, Goldstein SL14. Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshopPediatr Res. 2017;82(4):569-573. doi:10.1038/pr.2017.136
  10. García-García, Inés; Bouet, Kary; García-Fragoso, Lourdes; Rivera-González, Juan. Addressing Health Disparities and Cultural Competency in Reproductive Health Through Active Learning in the University of Puerto Rico, School of Medicine. J Health Dispar Res Pract. Volume 10, Issue 3, Fall 2017, pp. 109-115.
  11. I Esquilín, G Reyes, R Pérez. Bioética, Determinantes Sociales, Política y Sistemas de Salud. Francisco J Leon Correa (Ed.)  La devaluación del más vulnerable: La epidemia de Zika  en las Américas (pp 117-126). Santiago de Chile: Fundación Ciencia y Vida. 2017.
  12. Zappitelli M, Ambalavanan N, Askenazi DJ, Moxey-Mims MM, Kimmel PL, Star RA, Abitbol CL, Brophy PD, Hidalgo G, Hanna M, Morgan CM, Raju TNK, Ray P, Reyes-Bou Z, Roushdi A, Goldstein SL. Developing a neonatal acute kidney injury research definition: a report from the NIDDK neonatal AKI workshop. Pediatric Research 82, 569–573 (2017).
  13. Yiamira Oquendo Ocasio MD, Inés García-García, MD, Cleolfa Santana-Pérez, RN, MSN, Lourdes García-Fragoso MD. El Impacto de Proyectos Educativos sobre Higiene de Manos para Profesionales de la Salud. Journal of the College of Physicians Surgeons of Puerto Rico. April-June 2017 pp: 21-23.
  14. Rodríguez- Nieves, Melanie; García-García, Inés; García-Fragoso, Lourdes. Perinatally acquired chikungunya infection: The Puerto Rico experience. Pediatr Infect Dis J. 2016 Oct;35(10):1163.
  15. Gely L, Lugo-Vicente H, Correa-Rivas M, Bouet K, Reyes Bou Z, Suleiman M, García I. Neonatal Sacrococcygeal Neuroblastoma Mimicking a Teratoma. Case Rep Pediatr. 2017:3624847.
  16. Fargas-Berríos N, García-Fragoso L, García-García I, Valcárcel M. Neonatal Hyperglycemia due to Transient Neonatal Diabetes Mellitus in Puerto Rico. Case Rep Pediatr. 2015:98424.
  17. Matías I, García I, García-Fragoso L, Puig G, Pedraza L, Rodríguez L, Santaella A, Arce S, Toledo M, Soto E, Valcárcel M. Trends of Respiratory Syncytial Virus Infections in Children under 2 Years of Age in Puerto Rico. PR Health Sci J. 2015 Jun;34(2):98-101.